ES2108048T3 - Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. - Google Patents

Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.

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Publication number
ES2108048T3
ES2108048T3 ES91916470T ES91916470T ES2108048T3 ES 2108048 T3 ES2108048 T3 ES 2108048T3 ES 91916470 T ES91916470 T ES 91916470T ES 91916470 T ES91916470 T ES 91916470T ES 2108048 T3 ES2108048 T3 ES 2108048T3
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Prior art keywords
heterological
antibodies
producing
production
transgenic animals
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Expired - Lifetime
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ES91916470T
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English (en)
Inventor
Nils Lonberg
Robert M Kay
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Genpharm International Inc
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Genpharm International Inc
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Abstract

LA INVENCION SE REFIERE A ANIMALES TRANSGENICOS NO HUMANOS CAPACES DE PRODUCIR ANTICUERPOS HETEROLOGOS, POR EJEMPLO ANTICUERPOS CODIFICADOS POR GENES DE CADENA LIGERA Y PESADA DE INMUNOGLOBULINA QUE NO SE ENCUENTRA NORMALMENTE EN EL GENOMA DE ESPECIES ANIMALES NO HUMANAS. EN UN ASPECTO DE LA INVENCION, LOS TRANSGENES QUE CODIFICAN LAS CADENAS LIGERA Y PESADA DE LA INMUNOGLOBULINA HUMANA HETEROLOGA SE INTRODUCEN EN UN ANIMAL NO HUMANO FORMANDO DE ESTA FORMA UN ANIMAL TRANSGENICO CAPAZ DE PRODUCIR ANTICUERPOS CODIFICADOS POR LOS GENES DE LA INMUNOGLOBULINA HUMANA. TALES ANTICUERPOS HETEROLOGOS HUMANOS SE PRODUCEN EN LAS CELULAS B QUE DESPUES DE ELLO SON INMORTALIZADAS, POR EJEMPLO, FUNDIENDOLAS CON UNA LINEA CELULAR INMORTAL TAL COMO UN MIELOMA O MANIPULANDO TALES CELULAS B MEDIANTE OTRAS TECNICAS PARA PERPETUAR UNA LINEA CELULAR CAPAZ DE PRODUCIR UN ANTICUERPO HETEROLOGO MONOCLONAL. LA INVENCION TAMBIEN SE REFIERE A LOS TRANSGENES DE LA INMUNOGLOBULINA DE CADENA LIGERA Y PESADA PARA OBTENERTALES ANIMALES TRANSGENICOS NO HUMANOS ASI COMO A METODOS Y A VECTORES PARA ROMPER LA CADENA DE LA INMUNOGLOBULINA ENDOGENA EN EL ANIMAL TRANSGENICO. LA INVENCION TAMBIEN INCLUYE METODOS PARA GENERAR UN REPERTORIO DE SEGMENTOS DE GENES DE REGION VARIABLE DE INMUNOGLOBULINA SINTETICA USADO EN LA CONSTRUCCION TRANSGENICA Y A METODOS PARA INDUCIR LA PRODUCCION DE ANTICUERPOS HETEROLOGOS USANDO ANIMALES QUE CONTENGAN TRANSGENES DE INMUNOGLOBULINA DE CADENA LIGERA Y PESADA HETEROLOGA REORDENADA O NO REORDENADA.
ES91916470T 1990-08-29 1991-08-28 Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. Expired - Lifetime ES2108048T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57474890A 1990-08-29 1990-08-29
US57596290A 1990-08-31 1990-08-31

Publications (1)

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ES2108048T3 true ES2108048T3 (es) 1997-12-16

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ES91916470T Expired - Lifetime ES2108048T3 (es) 1990-08-29 1991-08-28 Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
ES97201755T Expired - Lifetime ES2246502T3 (es) 1990-08-29 1991-08-28 Animales no humanos transgenicos capaces de producir anticuerpos heterologos.

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ES97201755T Expired - Lifetime ES2246502T3 (es) 1990-08-29 1991-08-28 Animales no humanos transgenicos capaces de producir anticuerpos heterologos.

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US (1) US5569825A (es)
EP (2) EP0814159B1 (es)
JP (1) JP2938569B2 (es)
KR (2) KR100272077B1 (es)
AT (2) ATE158021T1 (es)
AU (1) AU8507191A (es)
CA (1) CA2089661C (es)
DE (2) DE69133476T2 (es)
DK (2) DK0546073T3 (es)
ES (2) ES2108048T3 (es)
GB (1) GB2272440A (es)
GR (1) GR3024701T3 (es)
WO (1) WO1992003918A1 (es)

Families Citing this family (3345)

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ES2087997T3 (es) * 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
US6713610B1 (en) * 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US6150584A (en) * 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5849288A (en) * 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5652373A (en) * 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US7041871B1 (en) * 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2108048T3 (es) * 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5877397A (en) * 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) * 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
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DK0546073T3 (da) 1998-02-02
KR100241638B1 (en) 2000-02-01
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CA2089661C (en) 2007-04-03
ATE158021T1 (de) 1997-09-15
GB9306502D0 (en) 1994-03-09
ES2246502T3 (es) 2006-02-16
DE69127627T2 (de) 1998-02-19
GR3024701T3 (en) 1997-12-31
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EP0546073B1 (en) 1997-09-10
CA2089661A1 (en) 1992-03-01
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US5569825A (en) 1996-10-29
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EP0546073A1 (en) 1993-06-16
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AU8507191A (en) 1992-03-30
EP0814159A3 (en) 1999-07-14
GB2272440A (en) 1994-05-18
JPH06500233A (ja) 1994-01-13
ATE300615T1 (de) 2005-08-15
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DE69133476D1 (de) 2005-09-01
EP0814159A2 (en) 1997-12-29

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