WO2015035044A2 - Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY - Google Patents

Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY Download PDF

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Publication number
WO2015035044A2
WO2015035044A2 PCT/US2014/054088 US2014054088W WO2015035044A2 WO 2015035044 A2 WO2015035044 A2 WO 2015035044A2 US 2014054088 W US2014054088 W US 2014054088W WO 2015035044 A2 WO2015035044 A2 WO 2015035044A2
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WO
WIPO (PCT)
Prior art keywords
polypeptide
substitution
antibody
fc
antibodies
Prior art date
Application number
PCT/US2014/054088
Other languages
French (fr)
Other versions
WO2015035044A3 (en
Inventor
Paul R. Hinton
Mengli XIONG
Veronica Juan
Original Assignee
Abbvie Biotherapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361873485P priority Critical
Priority to US61/873,485 priority
Application filed by Abbvie Biotherapeutics Inc. filed Critical Abbvie Biotherapeutics Inc.
Publication of WO2015035044A2 publication Critical patent/WO2015035044A2/en
Publication of WO2015035044A3 publication Critical patent/WO2015035044A3/en

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