MX356400B - Moduladores novedosos y metodos de uso. - Google Patents

Moduladores novedosos y metodos de uso.

Info

Publication number
MX356400B
MX356400B MX2013006569A MX2013006569A MX356400B MX 356400 B MX356400 B MX 356400B MX 2013006569 A MX2013006569 A MX 2013006569A MX 2013006569 A MX2013006569 A MX 2013006569A MX 356400 B MX356400 B MX 356400B
Authority
MX
Mexico
Prior art keywords
methods
novel modulators
modulators
novel
derivatives
Prior art date
Application number
MX2013006569A
Other languages
English (en)
Other versions
MX2013006569A (es
Inventor
Johannes Hampl
Scott J Dylla
Orit Foord
Robert A Stull
Original Assignee
Abbvie Stemcentrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/050451 external-priority patent/WO2012031280A2/en
Application filed by Abbvie Stemcentrx Llc filed Critical Abbvie Stemcentrx Llc
Publication of MX2013006569A publication Critical patent/MX2013006569A/es
Publication of MX356400B publication Critical patent/MX356400B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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Abstract

La presente invención se refiere a un anticuerpo quimérico, injertado con CDR, humanizado, o fragmento del mismo, caracterizado porque comprende tres CDRs de una región variable de cadena pesada establecida como SEQ ID NO: 157 y tres CDRs de una región variable de cadena ligera establecida como SEQ IDE NO: 159.
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