AR084208A1 - Moduladores del ligando de efrina a (efna) y metodos para su uso - Google Patents
Moduladores del ligando de efrina a (efna) y metodos para su usoInfo
- Publication number
- AR084208A1 AR084208A1 ARP110104586A ARP110104586A AR084208A1 AR 084208 A1 AR084208 A1 AR 084208A1 AR P110104586 A ARP110104586 A AR P110104586A AR P110104586 A ARP110104586 A AR P110104586A AR 084208 A1 AR084208 A1 AR 084208A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- cancer
- amino acid
- variable region
- acid sequence
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- G—PHYSICS
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Abstract
Un modulador del EFNA caracterizado porque comprende un anticuerpo monoclonal. Se provee además una composición farmacéutica que comprende el modelador aislado del EFNA útil en el tratamiento de un trastorno proliferativo, como un trastorno neoplásico. Reivindicación 1: Un modulador aislado caracterizado porque es un modulador del EFNA. Reivindicación 11: El modulador aislado del EFNA de la reivindicación 9, caracterizado porque dicho anticuerpo monoclonal comprende una región variable de la cadena liviana y una región variable de la cadena pesada, donde dicha región variable de la cadena liviana comprende una secuencia de aminoácidos que presenta una identidad de al menos 60% con una secuencia de aminoácidos que se selecciona del grupo que consiste en las secuencias de aminoácidos que se proveen en SEQ ID Nº 99, SEQ ID Nº 103, SEQ ID Nº 107, SEQ ID Nº 111, SEQ ID Nº 115, SEQ ID Nº 119, SEQ ID Nº 123, SEQ ID Nº 127, SEQ ID Nº 131, SEQ ID Nº 135, SEQ ID Nº 139, SEQ ID Nº 143, SEQ ID Nº 147, SEQ ID Nº 151, SEQ ID Nº 155, SEQ ID Nº 159 y SEQ ID Nº 163, y donde dicha región variable de la cadena pesada comprende una secuencia de aminoácidos que presenta una identidad de al menos 60% con una secuencia de aminoácidos que se selecciona del grupo que consiste en las secuencias de aminoácidos que se proveen en SEQ ID Nº 97, SEQ ID Nº 101, SEQ ID Nº 105, SEQ ID Nº 109, SEQ ID Nº 113, SEQ ID Nº 117, SEQ ID Nº 121, SEQ ID Nº 125, SEQ ID Nº 129, SEQ ID Nº 133, SEQ ID Nº 137, SEQ ID Nº 141, SEQ ID Nº 145, SEQ ID Nº 149, SEQ ID Nº 153, SEQ ID Nº 157 y SEQ ID Nº 161. Reivindicación 13: Un ácido nucleico caracterizado porque codifica la secuencia de aminoácidos de una región variable de la cadena pesada o la secuencia de aminoácidos de una región variable de la cadena liviana de acuerdo con la reivindicación 11. Reivindicación 14: Un vector caracterizado porque comprende un ácido nucleico de acuerdo con la reivindicación 13. Reivindicación 15: Una célula huésped caracterizada porque comprende un vector de acuerdo con la reivindicación 14. Reivindicación 41: El método de la reivindicación 40, caracterizado porque dicho trastorno neoplástico comprende el cáncer de las glándulas adrenales, el cáncer de vejiga, el cáncer cervical, el cáncer de endometrio, el cáncer de riñón, el cáncer de hígado, el cáncer de pulmón, el cáncer de ovario, el cáncer colorrectal, el cáncer de páncreas, el cáncer de próstata o el cáncer de mama. Reivindicación 91: Un método para inhibir o prevenir las metástasis en un sujeto que lo necesita, caracterizado porque comprende un paso en el que se le administra una cantidad eficaz para aplicaciones farmacéuticas de un modulador del EFNA.
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US (5) | US20140302034A1 (es) |
EP (2) | EP2648748A1 (es) |
JP (2) | JP6279903B2 (es) |
KR (1) | KR20140031175A (es) |
CN (2) | CN106279415A (es) |
AR (1) | AR084208A1 (es) |
AU (4) | AU2011360938B2 (es) |
BR (2) | BR112013014321A2 (es) |
CA (2) | CA2820885A1 (es) |
CO (1) | CO6821883A2 (es) |
MX (1) | MX356400B (es) |
NZ (3) | NZ705008A (es) |
PE (2) | PE20140673A1 (es) |
PH (1) | PH12017501139A1 (es) |
RU (2) | RU2592672C9 (es) |
SG (3) | SG10201601792UA (es) |
TW (2) | TWI585106B (es) |
WO (2) | WO2012078813A2 (es) |
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