MX2021001418A - Produccion de proteinas heteromultimericas usando celulas de mamifero. - Google Patents

Produccion de proteinas heteromultimericas usando celulas de mamifero.

Info

Publication number
MX2021001418A
MX2021001418A MX2021001418A MX2021001418A MX2021001418A MX 2021001418 A MX2021001418 A MX 2021001418A MX 2021001418 A MX2021001418 A MX 2021001418A MX 2021001418 A MX2021001418 A MX 2021001418A MX 2021001418 A MX2021001418 A MX 2021001418A
Authority
MX
Mexico
Prior art keywords
production
mammalian cells
heteromultimeric proteins
heteromultimeric
proteins
Prior art date
Application number
MX2021001418A
Other languages
English (en)
Inventor
Whitney Shatz
Justin Scheer
Domingos Ng
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2021001418A publication Critical patent/MX2021001418A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells

Abstract

En la presente se describen métodos para la producción eficaz de anticuerpos y otros completos de proteínas multiméricas (denominados colectivamente en la presente proteínas heteromultiméricas) capaces de unirse específicamente a más de una diana. Las dianas pueden ser, por ejemplo, epítopos diferentes ubicados en una única molécula o ubicados en moléculas diferentes.
MX2021001418A 2014-05-06 2016-11-03 Produccion de proteinas heteromultimericas usando celulas de mamifero. MX2021001418A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461989509P 2014-05-06 2014-05-06

Publications (1)

Publication Number Publication Date
MX2021001418A true MX2021001418A (es) 2021-04-12

Family

ID=54392973

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016014409A MX2016014409A (es) 2014-05-06 2015-05-06 Produccion de proteinas heteromultimericas usando celulas de mamifero.
MX2021001418A MX2021001418A (es) 2014-05-06 2016-11-03 Produccion de proteinas heteromultimericas usando celulas de mamifero.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016014409A MX2016014409A (es) 2014-05-06 2015-05-06 Produccion de proteinas heteromultimericas usando celulas de mamifero.

Country Status (14)

Country Link
US (2) US10941190B2 (es)
EP (2) EP3140392B1 (es)
JP (3) JP6715186B2 (es)
KR (2) KR102603417B1 (es)
CN (1) CN106471117A (es)
BR (2) BR112016024462B1 (es)
CA (1) CA2943707A1 (es)
ES (1) ES2955736T3 (es)
HR (1) HRP20231139T1 (es)
HU (1) HUE063273T2 (es)
MX (2) MX2016014409A (es)
PL (1) PL3140392T3 (es)
RU (1) RU2727012C2 (es)
WO (1) WO2015171822A1 (es)

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BR112016024462B1 (pt) * 2014-05-06 2022-12-27 Genentech, Inc Métodos para a preparação de um anticorpo
US10696722B2 (en) 2016-08-10 2020-06-30 Ajou University Industry-Academic Cooperation Foundation Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same
CA3048467A1 (en) * 2016-12-29 2018-07-05 Development Center For Biotechnology Klk6-mediated cns-specific antibody prodrug activation
TW202016151A (zh) 2018-06-09 2020-05-01 德商百靈佳殷格翰國際股份有限公司 針對癌症治療之多特異性結合蛋白
AU2019318087A1 (en) * 2018-08-08 2021-03-04 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD 16 and a tumor-associated antigen
BR112021007175A2 (pt) 2018-10-23 2021-08-10 Dragonfly Therapeutics, Inc. proteínas fundidas a fc heterodimérico
MX2023006650A (es) 2020-12-07 2023-06-21 UCB Biopharma SRL Anticuerpos multiespecificos y combinaciones de anticuerpos.

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Publication number Publication date
CA2943707A1 (en) 2015-11-12
HRP20231139T1 (hr) 2024-01-05
RU2727012C2 (ru) 2020-07-17
BR112016024462B1 (pt) 2022-12-27
MX2016014409A (es) 2017-01-20
US10941190B2 (en) 2021-03-09
EP3140392C0 (en) 2023-07-26
US20220002386A1 (en) 2022-01-06
CN106471117A (zh) 2017-03-01
EP3140392A4 (en) 2018-03-14
WO2015171822A1 (en) 2015-11-12
EP4306544A3 (en) 2024-03-20
EP3140392B1 (en) 2023-07-26
BR112016024462A2 (pt) 2017-08-15
ES2955736T3 (es) 2023-12-05
KR102603417B1 (ko) 2023-11-20
JP2023093462A (ja) 2023-07-04
KR20230164192A (ko) 2023-12-01
EP3140392A1 (en) 2017-03-15
JP2017514491A (ja) 2017-06-08
JP7253518B2 (ja) 2023-04-06
JP2020178691A (ja) 2020-11-05
PL3140392T3 (pl) 2023-11-27
JP6715186B2 (ja) 2020-07-01
EP4306544A2 (en) 2024-01-17
BR122021009041B1 (pt) 2022-11-29
RU2016142324A (ru) 2018-06-07
KR20170002405A (ko) 2017-01-06
US20170260252A1 (en) 2017-09-14
HUE063273T2 (hu) 2024-01-28
RU2016142324A3 (es) 2019-02-19

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