RU2021124437A - Конструкции, направленные на комплексы пептида afp/mhc, и виды их использования - Google Patents

Конструкции, направленные на комплексы пептида afp/mhc, и виды их использования Download PDF

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RU2021124437A
RU2021124437A RU2021124437A RU2021124437A RU2021124437A RU 2021124437 A RU2021124437 A RU 2021124437A RU 2021124437 A RU2021124437 A RU 2021124437A RU 2021124437 A RU2021124437 A RU 2021124437A RU 2021124437 A RU2021124437 A RU 2021124437A
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seq
amino acid
acid sequence
cdr
variable domain
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RU2021124437A
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Чэн Лю
Хонг ЛЮ
Иян СЮЙ
Цзиньги СЯН
Ли Лонг
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Еурека Терапьютикс, Инк.
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Claims (25)

1. Способ лечения индивидуума, страдающего AFP-положительным заболеванием, включающий введение индивидууму эффективного количества фармацевтической композиции, содержащей конструкцию к AMC, содержащую фрагмент антитела, который специфически связывается с комплексом, содержащим пептид альфа-фетопротеин (AFP) и белок главного комплекса гистосовместимости (MHC) I класса (комплекс AFP/MHC I класса или AMC), где пептид AFP имеет аминокислотную последовательность FMNKFIYEI (SEQ ID NO: 4).
2. Способ по п. 1, где белок MHC I класса представляет собой HLA-A*02:01 подтип HLA-A02 аллель.
3. Способ по п. 1 или 2, где конструкция к AMC связывается с комплексом AFP/MHC I класса с равновесной константой диссоциации (Kd) приблизительно от 0,1 пМ приблизительно до 500 нМ.
4. Способ по любому из пп. 1-3, где фрагмент антитела содержит:
(1) вариабельный домен тяжелой цепи, содержащий определяющую комплементарность область тяжелой цепи (HC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 62, HC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 72, HC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 82; и
вариабельный домен легкой цепи, содержащий определяющую комплементарность область легкой цепи (LC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 95, LC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 105, и LC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 115;
(2) вариабельный домен тяжелой цепи, содержащий определяющую комплементарность область тяжелой цепи (HC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 63, HC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 73, HC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 83; и
вариабельный домен легкой цепи, содержащий определяющую комплементарность область легкой цепи (LC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 96, LC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 106, и LC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 116;
(3) вариабельный домен тяжелой цепи, содержащий определяющую комплементарность область тяжелой цепи (HC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 64, HC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 74, HC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 84; и
вариабельный домен легкой цепи, содержащий определяющую комплементарность область легкой цепи (LC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 97, LC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 107, и LC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 117;
(4) вариабельный домен тяжелой цепи, содержащий определяющую комплементарность область тяжелой цепи (HC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 65, HC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 75, HC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 85; и
вариабельный домен легкой цепи, содержащий определяющую комплементарность область легкой цепи (LC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 98, LC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 108, и LC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 118; или
(5) вариабельный домен тяжелой цепи, содержащий определяющую комплементарность область тяжелой цепи (HC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 66, HC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 76, HC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 86; и
вариабельный домен легкой цепи, содержащий определяющую комплементарность область легкой цепи (LC-CDR) 1, содержащую аминокислотную последовательность SEQ ID NO: 99, LC-CDR 2, содержащую аминокислотную последовательность SEQ ID NO: 109, и LC-CDR 3, содержащую аминокислотную последовательность SEQ ID NO: 119.
5. Способ по любому из пп. 1-4, где фрагмент антитела содержит:
вариабельный домен тяжелой цепи, содержащий аминокислотную последовательность SEQ ID NO: 22 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 22, и вариабельный домен легкой цепи, содержащий аминокислотную последовательность SEQ ID NO: 32 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 32;
вариабельный домен тяжелой цепи, содержащий аминокислотную последовательность SEQ ID NO: 23 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 23, и вариабельный домен легкой цепи, содержащий аминокислотную последовательность SEQ ID NO: 33 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 33;
вариабельный домен тяжелой цепи, содержащий аминокислотную последовательность SEQ ID NO: 24 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 24, и вариабельный домен легкой цепи, содержащий аминокислотную последовательность SEQ ID NO: 34 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 34;
вариабельный домен тяжелой цепи, содержащий аминокислотную последовательность SEQ ID NO: 25 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 25, и вариабельный домен легкой цепи, содержащий аминокислотную последовательность SEQ ID NO: 35 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 35; или
вариабельный домен тяжелой цепи, содержащий аминокислотную последовательность SEQ ID NO: 26 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 26, и вариабельный домен легкой цепи, содержащий аминокислотную последовательность SEQ ID NO: 36 или ее вариант, имеющий по меньшей мере 95% идентичность к последовательности SEQ ID NO: 36.
6. Способ по любому из пп. 1-5, где конструкция к AMC представляет собой антитело или его антигенсвязывающий фрагмент.
7. Способ по любому из пп. 1-5, где конструкция к AMC содержит второй фрагмент, выбранный из группы, состоящей из второго фрагмента антитела, специфически связывающегося со вторым антигеном, фрагмента, содержащего трансмембранный домен и внутриклеточный сигнальный домен, и эффекторную молекулу.
8. Способ по п. 7, где второй фрагмент содержит трансмембранный домен и внутриклеточный сигнальный домен, и где фармацевтическая композиция содержит эффекторную клетку, экспрессирующую конструкцию к AMC.
9. Выделенная конструкция к AMC, содержащая фрагмент антитела, который специфически связывается с комплексом, содержащим пептид альфа-фетопротеин (AFP) и белок главного комплекса гистосовместимости (MHC) I класса (комплекс AFP/MHC I класса или AMC), где пептид AFP имеет аминокислотную последовательность FMNKFIYEI (SEQ ID NO: 4).
10. Эффекторная клетка, экспрессирующая выделенную конструкцию к AMC по п. 9.
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