EA202091590A1 - Антитела против pd-l1 и варианты их применения - Google Patents

Антитела против pd-l1 и варианты их применения

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Publication number
EA202091590A1
EA202091590A1 EA202091590A EA202091590A EA202091590A1 EA 202091590 A1 EA202091590 A1 EA 202091590A1 EA 202091590 A EA202091590 A EA 202091590A EA 202091590 A EA202091590 A EA 202091590A EA 202091590 A1 EA202091590 A1 EA 202091590A1
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EA
Eurasian Patent Office
Prior art keywords
seq
fragments
antibodies
antibodies against
application options
Prior art date
Application number
EA202091590A
Other languages
English (en)
Inventor
Лэй Фан
Юнцян ВАН
Чжэнъи Ван
Бинши Гуо
Цзинъу Цзан
Original Assignee
Ай-Маб Биофарма Юэс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ай-Маб Биофарма Юэс Лимитед filed Critical Ай-Маб Биофарма Юэс Лимитед
Publication of EA202091590A1 publication Critical patent/EA202091590A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

Abstract

Предложены антитела против PD-L1 или их фрагменты. Указанные антитела или их фрагменты специфически связываются с иммуноглобулиновым С-доменом белка PD-L1. В различных примерах указанные антитела или их фрагменты включают VH CDR1 из SEQ ID NO: 1, VH CDR2 из SEQ ID NO: 116, VH CDR3 из SEQ ID NO: 117, VL CDR1 из SEQ ID NO: 4, VL CDR2 из SEQ ID NO: 5 и VL CDR3 из SEQ ID NO: 6 или варианты каждого из перечисленных. Также предложены способы применения указанных антител или их фрагментов для лечения и диагностики заболеваний, таких как рак и инфекционные заболевания.
EA202091590A 2018-03-29 2019-03-29 Антитела против pd-l1 и варианты их применения EA202091590A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2018081079 2018-03-29
PCT/CN2019/080458 WO2019185029A1 (en) 2018-03-29 2019-03-29 Anti-pd-l1 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
EA202091590A1 true EA202091590A1 (ru) 2021-01-21

Family

ID=68060946

Family Applications (1)

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EA202091590A EA202091590A1 (ru) 2018-03-29 2019-03-29 Антитела против pd-l1 и варианты их применения

Country Status (18)

Country Link
US (2) US11220546B2 (ru)
EP (1) EP3589660A4 (ru)
JP (1) JP7124257B2 (ru)
KR (2) KR102475106B1 (ru)
CN (1) CN110891975B (ru)
AU (1) AU2019241339B2 (ru)
BR (1) BR112020019827A2 (ru)
CA (1) CA3086434C (ru)
CL (1) CL2020002223A1 (ru)
EA (1) EA202091590A1 (ru)
IL (1) IL275734B (ru)
MX (1) MX2020007842A (ru)
MY (1) MY188237A (ru)
PE (1) PE20210377A1 (ru)
PH (1) PH12020551173A1 (ru)
SG (1) SG11202006008WA (ru)
UA (1) UA125918C2 (ru)
WO (1) WO2019185029A1 (ru)

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MX2018015584A (es) * 2016-06-13 2019-09-18 I Mab Anticuerpos anti-pd-l1 y usos de los mismos.
CN112041348B (zh) * 2018-07-25 2023-09-22 天境生物科技(上海)有限公司 抗cd73抗pd-l1双特异性抗体
CA3109999A1 (en) * 2018-08-21 2020-02-27 Abl Bio Inc. Anti-pd-l1/anti-lag3 bispecific antibodies and uses thereof
WO2021097800A1 (en) * 2019-11-22 2021-05-27 Abl Bio Inc. Anti-pd-l1/anti-b7-h3 multispecific antibodies and uses thereof
WO2021219092A1 (en) * 2020-04-30 2021-11-04 I-Mab Biopharma Co., Ltd. Pharmaceutical compositionscontaining anti-cd47 antibodies
AU2021329378A1 (en) 2020-08-19 2023-03-23 Xencor, Inc. Anti-CD28 compositions
CN114195900B (zh) * 2020-09-17 2024-02-23 普米斯生物技术(珠海)有限公司 一种抗4-1bb/pd-l1双特异性抗体及其用途
CN114316045A (zh) * 2020-09-29 2022-04-12 锋宏生物医药科技(昆山)有限公司 抗pd-l1抗体及其用途
CN113234162B (zh) * 2020-12-24 2022-05-13 四川大学华西医院 一种靶向cd133的嵌合抗原受体t细胞
WO2022148414A1 (zh) * 2021-01-08 2022-07-14 北京韩美药品有限公司 特异性结合pd-l1的抗体及其抗原结合片段
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JP6526189B2 (ja) * 2014-07-03 2019-06-05 ベイジーン リミテッド 抗ｐｄ−ｌ１抗体並びにその治療及び診断のための使用
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MX2018015584A (es) * 2016-06-13 2019-09-18 I Mab Anticuerpos anti-pd-l1 y usos de los mismos.
CN107488229B (zh) 2016-06-13 2020-11-17 天境生物科技(上海)有限公司 Pd-l1抗体及其用途
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CN112041348B (zh) * 2018-07-25 2023-09-22 天境生物科技(上海)有限公司 抗cd73抗pd-l1双特异性抗体
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Also Published As

Publication number Publication date
KR102177931B1 (ko) 2020-11-13
JP2020518233A (ja) 2020-06-25
US11220546B2 (en) 2022-01-11
EP3589660A1 (en) 2020-01-08
IL275734A (en) 2020-08-31
CL2020002223A1 (es) 2021-01-29
KR20190128716A (ko) 2019-11-18
AU2019241339B2 (en) 2021-08-12
JP7124257B2 (ja) 2022-08-24
US20200157222A1 (en) 2020-05-21
KR20200130747A (ko) 2020-11-19
UA125918C2 (uk) 2022-07-06
IL275734B (en) 2022-06-01
US20220119531A1 (en) 2022-04-21
EP3589660A4 (en) 2021-04-07
MY188237A (en) 2021-11-24
CN110891975B (zh) 2023-11-10
AU2019241339A1 (en) 2019-11-14
PH12020551173A1 (en) 2021-05-31
MX2020007842A (es) 2020-09-25
BR112020019827A2 (pt) 2021-01-05
CA3086434A1 (en) 2019-10-03
KR102475106B1 (ko) 2022-12-08
WO2019185029A1 (en) 2019-10-03
SG11202006008WA (en) 2020-07-29
CA3086434C (en) 2024-01-09
PE20210377A1 (es) 2021-03-02
CN110891975A (zh) 2020-03-17

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