EA201991099A1 - Антитела против cd73 и их применение - Google Patents

Антитела против cd73 и их применение

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EA201991099A1
EA201991099A1 EA201991099A EA201991099A EA201991099A1 EA 201991099 A1 EA201991099 A1 EA 201991099A1 EA 201991099 A EA201991099 A EA 201991099A EA 201991099 A EA201991099 A EA 201991099A EA 201991099 A1 EA201991099 A1 EA 201991099A1
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Eurasian Patent Office
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seq
fragments
antibodies
antibodies against
application
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EA201991099A
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English (en)
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Чжэнъи Ван
Лэй Фан
Бинши Гуо
Цзинъу Цзан
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Ай-Маб Биофарма Юэс Лимитед
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Publication of EA201991099A1 publication Critical patent/EA201991099A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N5/0602—Vertebrate cells
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/914—Hydrolases (3)
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Abstract

Предложены антитела против CD73 или их фрагменты. Указанные антитела или фрагменты содержат CDR1 VH согласно SEQ ID NO: 1, CDR2 VH согласно SEQ ID NO: 2, CDR3 VH согласно SEQ ID NO: 3, CDR1 VL согласно SEQ ID NO: 4, CDR2 VL согласно SEQ ID NO: 5 и CDR3 VL согласно SEQ ID NO: 6 или варианты каждого из них. В более общем случае описаны антитела или их фрагменты, обладающие специфичностью по отношению к одному или более аминокислотным остаткам, выбранным из С-концевой половины белка CD73 человека, например аминокислотным остаткам в С-концевых доменах. Аминокислоты специфических эпитопов в этих доменах включают Y345, D399, Е400, R401 и R480. Кроме того, предложены способы применения указанных антител или их фрагментов для лечения и диагностики заболеваний, например рака.
EA201991099A 2017-01-24 2018-01-23 Антитела против cd73 и их применение EA201991099A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2017072445 2017-01-24
PCT/CN2018/073746 WO2018137598A1 (en) 2017-01-24 2018-01-23 Anti-cd73 antibodies and uses thereof

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US (2) US10584169B2 (ru)
EP (2) EP4050030A1 (ru)
JP (1) JP7206193B2 (ru)
KR (3) KR20180093088A (ru)
CN (2) CN112279918A (ru)
AU (2) AU2018213549B2 (ru)
BR (1) BR112019012040A2 (ru)
CA (1) CA3045376C (ru)
CL (1) CL2019001756A1 (ru)
CO (1) CO2019006657A2 (ru)
DK (1) DK3383916T3 (ru)
EA (1) EA201991099A1 (ru)
ES (1) ES2908662T3 (ru)
HR (1) HRP20220629T1 (ru)
HU (1) HUE058975T2 (ru)
IL (2) IL267942B (ru)
LT (1) LT3383916T (ru)
MX (1) MX2019008758A (ru)
MY (1) MY188386A (ru)
NZ (1) NZ753714A (ru)
PE (1) PE20191208A1 (ru)
PH (1) PH12019550087A1 (ru)
PL (1) PL3383916T3 (ru)
PT (1) PT3383916T (ru)
RS (1) RS63195B1 (ru)
SI (1) SI3383916T1 (ru)
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