BR112019012040A2 - anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73. - Google Patents

anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73.

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Publication number
BR112019012040A2
BR112019012040A2 BR112019012040-8A BR112019012040A BR112019012040A2 BR 112019012040 A2 BR112019012040 A2 BR 112019012040A2 BR 112019012040 A BR112019012040 A BR 112019012040A BR 112019012040 A2 BR112019012040 A2 BR 112019012040A2
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BR
Brazil
Prior art keywords
seq
treatment
methods
fragment
therapy
Prior art date
Application number
BR112019012040-8A
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English (en)
Inventor
Guo Bingshi
Zang Jingwu
Fang Lei
Wang Zhengyi
Original Assignee
I Mab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I Mab filed Critical I Mab
Publication of BR112019012040A2 publication Critical patent/BR112019012040A2/pt

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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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Abstract

são providos anticorpos anti-cd73 ou fragmentos dos mesmos. os anticorpos ou fragmentos, portanto, incluem uma vh cdr1 de seq id no: 1, uma vh cdr2 de seq id no: 2, uma vh cdr3 de seq id no: 3, uma vl cdr1 de seq id no: 4, uma vl cdr2 de seq id no: 5, e uma vl cdr3 de seq id no: 6 ou variantes de cada uma das mesmas. mais geralmente, são descritos anticorpos ou fragmentos dos mesmos que possuem especificidade a um ou mais resíduos de aminoácidos selecionados a partir da metade c-terminal de uma proteína de cd73 humana, tais como aquelas nos domínios de c-terminal. aminoácidos de epítopo específicos nestes domínios incluem y345, d399, e400, r401 e r480. são providos também métodos de uso dos anticorpos ou fragmentos dos mesmos para o tratamento e diagnóstico de doenças tais como o câncer.
BR112019012040-8A 2017-01-24 2018-01-23 anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73. BR112019012040A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2017072445 2017-01-24
PCT/CN2018/073746 WO2018137598A1 (en) 2017-01-24 2018-01-23 Anti-cd73 antibodies and uses thereof

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