BR112017005110A2 - anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo, molécula isolada de ácido nucleico, composição farmacêutica, e, método para diminuir níveis de glicose no sangue ou para tratar uma condição ou doença. - Google Patents
anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo, molécula isolada de ácido nucleico, composição farmacêutica, e, método para diminuir níveis de glicose no sangue ou para tratar uma condição ou doença.Info
- Publication number
- BR112017005110A2 BR112017005110A2 BR112017005110A BR112017005110A BR112017005110A2 BR 112017005110 A2 BR112017005110 A2 BR 112017005110A2 BR 112017005110 A BR112017005110 A BR 112017005110A BR 112017005110 A BR112017005110 A BR 112017005110A BR 112017005110 A2 BR112017005110 A2 BR 112017005110A2
- Authority
- BR
- Brazil
- Prior art keywords
- blood glucose
- glucose levels
- antigen
- disease
- treating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
a presente invenção provê anticorpos que se ligam a glucagon e método para uso dos mesmos. de acordo com certas modalidades, os anticorpos da invenção se ligam a gcg humana com alta afinidade. os anticorpos da invenção podem ser completamente anticorpos humanos. os anticorpos da invenção são úteis para o tratamento de várias doenças ou distúrbios caracterizados por níveis elevados de glicose no sangue, assim como outros distúrbios relacionados à gcg.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462050889P | 2014-09-16 | 2014-09-16 | |
PCT/US2015/050281 WO2016044337A1 (en) | 2014-09-16 | 2015-09-15 | Anti-glucagon antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017005110A2 true BR112017005110A2 (pt) | 2018-01-23 |
Family
ID=54197130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017005110A BR112017005110A2 (pt) | 2014-09-16 | 2015-09-15 | anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo, molécula isolada de ácido nucleico, composição farmacêutica, e, método para diminuir níveis de glicose no sangue ou para tratar uma condição ou doença. |
Country Status (16)
Country | Link |
---|---|
US (2) | US9657099B2 (pt) |
EP (1) | EP3194441A1 (pt) |
JP (1) | JP2017533695A (pt) |
KR (1) | KR20170062466A (pt) |
CN (1) | CN107001461A (pt) |
AU (1) | AU2015317899A1 (pt) |
BR (1) | BR112017005110A2 (pt) |
CA (1) | CA2960763A1 (pt) |
CL (1) | CL2017000651A1 (pt) |
CO (1) | CO2017002719A2 (pt) |
EA (1) | EA201790377A1 (pt) |
IL (1) | IL251000A0 (pt) |
MX (1) | MX2017003535A (pt) |
PH (1) | PH12017500402A1 (pt) |
SG (1) | SG11201701711VA (pt) |
WO (1) | WO2016044337A1 (pt) |
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AU2016254215A1 (en) | 2015-04-30 | 2017-10-26 | President And Fellows Of Harvard College | Anti-aP2 antibodies and antigen binding agents to treat metabolic disorders |
TW202330904A (zh) | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
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CN107586336A (zh) * | 2016-07-09 | 2018-01-16 | 复旦大学 | 针对寨卡病毒的全人源单克隆抗体及应用 |
WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
SG11201901355SA (en) | 2016-08-30 | 2019-03-28 | Regeneron Pharma | Methods of treating severe insulin resistance by interfering with glucagon receptor signaling |
US20190248888A1 (en) | 2016-10-20 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
AU2018213374A1 (en) | 2017-01-27 | 2019-07-11 | Ngm Biopharmaceuticals, Inc. | Glucagon receptor binding proteins and methods of use thereof |
WO2018227200A1 (en) | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders |
BR112020000127A2 (pt) | 2017-07-06 | 2020-07-07 | Regeneron Pharmaceuticals, Inc. | método para selecionar um hidrolisado de soja, e, glicoproteína |
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CN115925882A (zh) | 2017-12-22 | 2023-04-07 | 瑞泽恩制药公司 | 用于表征药物产品杂质的系统和方法 |
BR112020013336A2 (pt) | 2018-01-31 | 2020-12-01 | Regeneron Pharmaceuticals, Inc. | produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário. |
TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
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WO2019173417A1 (en) * | 2018-03-08 | 2019-09-12 | Phanes Therapeutics, Inc. | Anti-tip-1 antibodies and uses thereof |
US11054389B2 (en) | 2018-03-19 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
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CA3150234C (en) | 2019-09-24 | 2023-12-12 | Robert Stairs | Systems and methods for chromatography use and regeneration |
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KR20230150300A (ko) | 2021-03-03 | 2023-10-30 | 리제너론 파마슈티칼스 인코포레이티드 | 단백질 점도를 정량화하고 변경시키기 위한 시스템 및 방법 |
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2015
- 2015-09-15 WO PCT/US2015/050281 patent/WO2016044337A1/en active Application Filing
- 2015-09-15 MX MX2017003535A patent/MX2017003535A/es unknown
- 2015-09-15 US US14/855,274 patent/US9657099B2/en active Active
- 2015-09-15 AU AU2015317899A patent/AU2015317899A1/en not_active Abandoned
- 2015-09-15 JP JP2017514534A patent/JP2017533695A/ja active Pending
- 2015-09-15 SG SG11201701711VA patent/SG11201701711VA/en unknown
- 2015-09-15 CA CA2960763A patent/CA2960763A1/en not_active Abandoned
- 2015-09-15 CN CN201580061778.6A patent/CN107001461A/zh active Pending
- 2015-09-15 BR BR112017005110A patent/BR112017005110A2/pt not_active Application Discontinuation
- 2015-09-15 EA EA201790377A patent/EA201790377A1/ru unknown
- 2015-09-15 EP EP15770766.2A patent/EP3194441A1/en not_active Withdrawn
- 2015-09-15 KR KR1020177008897A patent/KR20170062466A/ko unknown
-
2017
- 2017-03-03 PH PH12017500402A patent/PH12017500402A1/en unknown
- 2017-03-07 IL IL251000A patent/IL251000A0/en unknown
- 2017-03-16 CL CL2017000651A patent/CL2017000651A1/es unknown
- 2017-03-22 CO CONC2017/0002719A patent/CO2017002719A2/es unknown
- 2017-04-17 US US15/489,587 patent/US20170218065A1/en not_active Abandoned
Also Published As
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MX2017003535A (es) | 2017-10-27 |
PH12017500402A1 (en) | 2017-07-17 |
EP3194441A1 (en) | 2017-07-26 |
CO2017002719A2 (es) | 2017-06-20 |
AU2015317899A1 (en) | 2017-04-06 |
CA2960763A1 (en) | 2016-03-24 |
EA201790377A1 (ru) | 2017-08-31 |
US9657099B2 (en) | 2017-05-23 |
US20170218065A1 (en) | 2017-08-03 |
KR20170062466A (ko) | 2017-06-07 |
SG11201701711VA (en) | 2017-04-27 |
WO2016044337A1 (en) | 2016-03-24 |
US20160075778A1 (en) | 2016-03-17 |
IL251000A0 (en) | 2017-04-30 |
CL2017000651A1 (es) | 2017-12-15 |
CN107001461A (zh) | 2017-08-01 |
JP2017533695A (ja) | 2017-11-16 |
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