BR112023018665A2 - Métodos e sistemas para desenvolvimento de protocolos de mistura - Google Patents

Métodos e sistemas para desenvolvimento de protocolos de mistura

Info

Publication number
BR112023018665A2
BR112023018665A2 BR112023018665A BR112023018665A BR112023018665A2 BR 112023018665 A2 BR112023018665 A2 BR 112023018665A2 BR 112023018665 A BR112023018665 A BR 112023018665A BR 112023018665 A BR112023018665 A BR 112023018665A BR 112023018665 A2 BR112023018665 A2 BR 112023018665A2
Authority
BR
Brazil
Prior art keywords
identifying
developing
systems
methods
predictive models
Prior art date
Application number
BR112023018665A
Other languages
English (en)
Inventor
Jordan Byrd
Matthew Oremland
Ross Kenyon
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112023018665A2 publication Critical patent/BR112023018665A2/pt

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/10—Analysis or design of chemical reactions, syntheses or processes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/20—Design optimisation, verification or simulation
    • G06F30/28—Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/808—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers driven from the bottom of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/85—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with two or more stirrers on separate shafts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/91—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with propellers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2207—Use of data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the computer programs, e.g. for manipulation, handling, production or compounding in mixing plants
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/80—Data visualisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C60/00—Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0404—Technical information in relation with mixing theories or general explanations of phenomena associated with mixing or generalizations of a concept by comparison of equivalent methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0409—Relationships between different variables defining features or parameters of the apparatus or process
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
    • G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
    • G05B13/04—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
    • G05B13/048—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators using a predictor
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B17/00—Systems involving the use of models or simulators of said systems

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Computing Systems (AREA)
  • Evolutionary Computation (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computer Hardware Design (AREA)
  • Fluid Mechanics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Algebra (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Geometry (AREA)
  • Automation & Control Theory (AREA)
  • Software Systems (AREA)
  • Analytical Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Medical Informatics (AREA)
  • Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Computer And Data Communications (AREA)
  • Communication Control (AREA)
  • Feedback Control In General (AREA)
  • Accessories For Mixers (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

métodos e sistemas para desenvolvimento de protocolos de mistura. um método para desenvolver um modelo preditivo pode incluir a identificação de parâmetros de protocolo de mistura para o modelo preditivo, a identificação de um critério de avaliação para o modelo preditivo, a seleção de valores de teste para os parâmetros do protocolo de mistura, a identificação de uma simulação de dinâmica computacional de fluidos (cfd) necessária para ser realizada em a fim de gerar os critérios de avaliação, conduzindo a simulação de cfd para cada combinação de valores de teste, gerando assim critérios de avaliação correspondentes a cada combinação de valores de teste, gerando um domínio de modelos preditivos potenciais relacionando os parâmetros do protocolo de mistura ao critério de avaliação, identificando um conjunto de modelos preditivos candidatos do domínio de modelos preditivos potenciais e classificando o conjunto de modelos preditivos candidatos.
BR112023018665A 2021-03-26 2022-03-25 Métodos e sistemas para desenvolvimento de protocolos de mistura BR112023018665A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163166504P 2021-03-26 2021-03-26
US202263298880P 2022-01-12 2022-01-12
PCT/US2022/071363 WO2022204728A1 (en) 2021-03-26 2022-03-25 Methods and systems for developing mixing protocols

Publications (1)

Publication Number Publication Date
BR112023018665A2 true BR112023018665A2 (pt) 2023-10-03

Family

ID=81308160

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023018665A BR112023018665A2 (pt) 2021-03-26 2022-03-25 Métodos e sistemas para desenvolvimento de protocolos de mistura

Country Status (11)

Country Link
US (1) US20220309215A1 (pt)
EP (1) EP4315344A1 (pt)
JP (1) JP2024519407A (pt)
KR (1) KR20230162932A (pt)
AU (1) AU2022243005A1 (pt)
BR (1) BR112023018665A2 (pt)
CA (1) CA3211302A1 (pt)
IL (1) IL305731A (pt)
MX (1) MX2023010794A (pt)
TW (1) TW202244475A (pt)
WO (1) WO2022204728A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024102680A1 (en) * 2022-11-07 2024-05-16 Regeneron Pharmaceuticals, Inc. Methods and systems for developing mixing protocols

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
CN1302337C (zh) 2002-03-08 2007-02-28 Asml荷兰有限公司 光刻投射设备、所用的反射掩模以及器件制作方法
CN102585002A (zh) 2006-06-02 2012-07-18 瑞泽恩制药公司 人il-6受体的高亲和力抗体
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
ME00973B (me) 2007-07-31 2012-06-20 Regeneron Pharma Humana antitjela prema humanom cd20 i postupak njihovog korišćenja
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
JO3340B1 (ar) 2010-05-26 2019-03-13 Regeneron Pharma مضادات حيوية لـعامل تمايز النمو 8 البشري
AR083044A1 (es) 2010-09-27 2013-01-30 Regeneron Pharma Anticuerpos anti-cd48 y usos de los mismos
MX366337B (es) 2010-10-06 2019-07-05 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r).
JO3756B1 (ar) 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
AR087329A1 (es) 2011-06-17 2014-03-19 Regeneron Pharma Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana
PT2780368T (pt) 2011-11-14 2018-03-22 Regeneron Pharma Composições e métodos para aumentar a massa muscular e a força muscular antagonizando especificamente gdf8 e/ou activina a
NZ627859A (en) 2012-01-23 2015-09-25 Regeneron Pharma Stabilized formulations containing anti-ang2 antibodies
JO3820B1 (ar) 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
TW201843172A (zh) 2012-06-25 2018-12-16 美商再生元醫藥公司 抗－ｅｇｆｒ抗體及其用途
CN104540852B (zh) 2012-08-13 2018-10-02 瑞泽恩制药公司 具有pH-依赖性结合特性的抗-PCSK9抗体
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
JO3405B1 (ar) 2013-01-09 2019-10-20 Regeneron Pharma الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
TWI659968B (zh) 2013-03-14 2019-05-21 再生元醫藥公司 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法
WO2014152195A1 (en) 2013-03-15 2014-09-25 Regeneron Pharmaceuticals, Inc. Il-33 antagonists and uses thereof
TWI641620B (zh) 2013-08-21 2018-11-21 再生元醫藥公司 抗－ｐｒｌｒ抗體及其用途
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
EA035809B1 (ru) 2014-03-11 2020-08-14 Регенерон Фармасьютикалс, Инк. АНТИТЕЛА ПРОТИВ EGFRvIII И ИХ ПРИМЕНЕНИЯ
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
RU2020103811A (ru) 2014-05-05 2020-02-18 Регенерон Фармасьютикалз, Инк. Гуманизированные животные по с5 и с3
KR20170062466A (ko) 2014-09-16 2017-06-07 리제너론 파마슈티칼스 인코포레이티드 항-글루카곤 항체 및 그것의 사용

Also Published As

Publication number Publication date
EP4315344A1 (en) 2024-02-07
MX2023010794A (es) 2023-10-25
TW202244475A (zh) 2022-11-16
JP2024519407A (ja) 2024-05-13
IL305731A (en) 2023-11-01
KR20230162932A (ko) 2023-11-29
US20220309215A1 (en) 2022-09-29
AU2022243005A1 (en) 2023-10-05
WO2022204728A1 (en) 2022-09-29
CA3211302A1 (en) 2022-09-29

Similar Documents

Publication Publication Date Title
Scheike et al. Predicting cumulative incidence probability by direct binomial regression
Hasselbring Benchmarking as empirical standard in software engineering research
US10296844B2 (en) Automatic discovery of message ordering invariants in heterogeneous logs
BR112023018665A2 (pt) Métodos e sistemas para desenvolvimento de protocolos de mistura
Xie et al. Statistical uncertainty analysis for stochastic simulation with dependent input models
Kumar et al. Reliability analysis of software with three types of errors and imperfect debugging using Markov model
Wang et al. Towards modeling the style of translators in neural machine translation
Tanneru et al. Quantifying uncertainty in natural language explanations of large language models
Jayabal et al. Clustering students based on student’s performance-a partial least squares path modeling (PLS-PM) study
EP4220646A8 (en) Basal culture medium development method, basal culture medium formulation and development, and system thereof
Schneider et al. Towards debugging sentiment lexicons
Kabir Compositional dependability analysis of dynamic systems with uncertainty
AR125604A1 (es) Métodos y sistemas para el desarrollo de protocolos de mezcla
Wickramage Quality assurance for data science: Making data science more scientific through engaging scientific method
BR112024001198A2 (pt) Treinamento de modelo usando aprendizagem federada
Liu et al. Enterprise-level controlled experiments at scale: Challenges and solutions
Diwaker et al. Assessment of Ant Colony using Component-Based Software Engineering Metrics
Sroka et al. Genetic algorithms in test design automation
Saveta et al. LANCE: A Generic Benchmark Generator for Linked Data.
Aslam et al. Refining active learning to increase behavioral coverage
Clark et al. Conservation of mass analysis for Bio-PEPA
Smith et al. Tools for analysis of accelerated life and degradation test data
Li et al. On the communication variability analysis of the NeCTAR research cloud system
McMillan Process-based diagnostics for hydrologic models
YAMADA Performability analysis considering debugging behaviors for open source solution