JO3756B1 - اجسام مضادة بشرية لمستقبلات الجلوكاجون - Google Patents

اجسام مضادة بشرية لمستقبلات الجلوكاجون

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Publication number
JO3756B1
JO3756B1 JOP/2011/0351A JOP20110351A JO3756B1 JO 3756 B1 JO3756 B1 JO 3756B1 JO P20110351 A JOP20110351 A JO P20110351A JO 3756 B1 JO3756 B1 JO 3756B1
Authority
JO
Jordan
Prior art keywords
span
antibodies
gcgr
rtl
dir
Prior art date
Application number
JOP/2011/0351A
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English (en)
Inventor
Okamoto Haruka
W Sleeman Mark
Harp Joyce
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Regeneron Pharma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45065985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3756(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of JO3756B1 publication Critical patent/JO3756B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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Abstract

<span dir="RTL">يقدم هذا الاختراع أضداد ترتبط بمستقبل الجلوكاجون التي حددت تسميتها ب </span>GCGR<span dir="RTL"> و طرق لاستخدامه. حسب تجسيدات معينة من الاختراع تكون الأضداد عبارة عن أضداد بشرية كاملة الطول التي ترتبط ب </span>GCGR <span dir="RTL"> البشري. تكون أضداد الاختراع مفيدة في خفض مستويات الجلوكوز في الدم و كما تكون مفيدة لعلاج الأمراض و الاضطرابات المصاحبة لنشاط أو أكثر من الأنشطو البيولوجية ل </span>GCGR<span dir="RTL">، بما فيها علاج مرض السكري و مضاعفات طويلة الأمد المصاحبة لمرض السكري أو غيرها من الاضطرابات الاستقلابية التي تتسم جزئيا بمستويات جلوكوز الدم المرتفعة.</span>
JOP/2011/0351A 2010-11-23 2011-11-20 اجسام مضادة بشرية لمستقبلات الجلوكاجون JO3756B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41640910P 2010-11-23 2010-11-23
US201161481958P 2011-05-03 2011-05-03
US201161551032P 2011-10-25 2011-10-25

Publications (1)

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JO3756B1 true JO3756B1 (ar) 2021-01-31

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JOP/2011/0351A JO3756B1 (ar) 2010-11-23 2011-11-20 اجسام مضادة بشرية لمستقبلات الجلوكاجون
JOP/2020/0202A JOP20200202A1 (ar) 2010-11-23 2020-08-24 اجسام مضادة بشرية لمستقبل الجلوكاجون

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US (8) US8545847B2 (ar)
EP (2) EP3608338B1 (ar)
JP (1) JP6100697B2 (ar)
KR (2) KR102048666B1 (ar)
CN (1) CN103314011B (ar)
AR (1) AR083972A1 (ar)
AU (1) AU2011331998B2 (ar)
BR (2) BR122020011337B1 (ar)
CA (2) CA3079595C (ar)
CL (1) CL2013001468A1 (ar)
EA (1) EA029669B1 (ar)
IL (1) IL226399A (ar)
JO (2) JO3756B1 (ar)
MX (1) MX336943B (ar)
MY (1) MY170570A (ar)
NZ (1) NZ610734A (ar)
PH (1) PH12013501048A1 (ar)
SG (3) SG10201500198TA (ar)
TW (1) TWI586686B (ar)
UY (1) UY33748A (ar)
WO (1) WO2012071372A2 (ar)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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JO3672B1 (ar) * 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
JO3756B1 (ar) 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
US8771696B2 (en) 2010-11-23 2014-07-08 Regeneron Pharmaceuticals, Inc. Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor
BR112013018740A2 (pt) 2011-01-28 2019-01-08 Sanofi Sa anticorpos humanos para pcsk9 para uso em métodos de tratamento de grupos específicos de indivíduos
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
CN103930444B (zh) 2011-09-16 2020-08-04 瑞泽恩制药公司 用前蛋白转化酶枯草溶菌素-9(PCSK9)抑制剂降低脂蛋白(a)水平的方法
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
US9758591B2 (en) 2012-08-24 2017-09-12 The Regents Of The University Of California Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
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