JOP20200202A1 - اجسام مضادة بشرية لمستقبل الجلوكاجون - Google Patents

اجسام مضادة بشرية لمستقبل الجلوكاجون

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Publication number
JOP20200202A1
JOP20200202A1 JOP/2020/0202A JOP20200202A JOP20200202A1 JO P20200202 A1 JOP20200202 A1 JO P20200202A1 JO P20200202 A JOP20200202 A JO P20200202A JO P20200202 A1 JOP20200202 A1 JO P20200202A1
Authority
JO
Jordan
Prior art keywords
antibodies
gcgr
glucagon receptor
human
human antibodies
Prior art date
Application number
JOP/2020/0202A
Other languages
English (en)
Inventor
W Sleeman Mark
Harp Joyce
Okamoto Haruka
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45065985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20200202(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of JOP20200202A1 publication Critical patent/JOP20200202A1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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Abstract

يتعلق الاختراع الحالي بتقديم أجسام مضادة تربط مستقبل الجلوكاجون البشري، و GCGRالمحدد وطرق استخدامها. طبقاً لنماذج معينة من الاختراع، تكون الأجسام المضادة أجسام مضادة بشرية تامة ترتبط بالمستقبل GCGR البشري. تكون الأجسام المضادة من الاختراع مفيدة في تقليل مستويات الجلوكوز في الدم أو مستويات الكيتون في الدم وتكون مفيدة كذلك في علاج الأمراض والاضطرابات المرتبطة بواحد أو أكثر من الأنشطة البيولوجية لمستقبل GCGR، بما في ذلك علاج مرض السكر، والحماض الكيتوني السكري، والمضاعفات على المدى البعيد المرتبطة بمرض السكر، أو الاضطرابات الأيضية الأخرى التي تتميز جزئيا بمستويات الجلوكوز المرتفعة في الدم
JOP/2020/0202A 2010-11-23 2020-08-24 اجسام مضادة بشرية لمستقبل الجلوكاجون JOP20200202A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41640910P 2010-11-23 2010-11-23
US201161481958P 2011-05-03 2011-05-03
US201161551032P 2011-10-25 2011-10-25

Publications (1)

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JOP20200202A1 true JOP20200202A1 (ar) 2022-10-30

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ID=45065985

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2011/0351A JO3756B1 (ar) 2010-11-23 2011-11-20 اجسام مضادة بشرية لمستقبلات الجلوكاجون
JOP/2020/0202A JOP20200202A1 (ar) 2010-11-23 2020-08-24 اجسام مضادة بشرية لمستقبل الجلوكاجون

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JOP/2011/0351A JO3756B1 (ar) 2010-11-23 2011-11-20 اجسام مضادة بشرية لمستقبلات الجلوكاجون

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US (7) US8545847B2 (ar)
EP (2) EP3608338A1 (ar)
JP (1) JP6100697B2 (ar)
KR (2) KR102048666B1 (ar)
CN (1) CN103314011B (ar)
AR (1) AR083972A1 (ar)
AU (1) AU2011331998B2 (ar)
BR (2) BR112013012782B1 (ar)
CA (2) CA3079595C (ar)
CL (1) CL2013001468A1 (ar)
EA (1) EA029669B1 (ar)
IL (1) IL226399A (ar)
JO (2) JO3756B1 (ar)
MX (1) MX336943B (ar)
MY (1) MY170570A (ar)
NZ (1) NZ610734A (ar)
SG (3) SG190398A1 (ar)
TW (1) TWI586686B (ar)
UY (1) UY33748A (ar)
WO (1) WO2012071372A2 (ar)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3672B1 (ar) * 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US8771696B2 (en) 2010-11-23 2014-07-08 Regeneron Pharmaceuticals, Inc. Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor
JO3756B1 (ar) 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
EP4252857A3 (en) 2011-09-16 2023-12-06 Regeneron Pharmaceuticals, Inc. Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9)
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
PT2888283T (pt) 2012-08-24 2018-11-16 Univ California Anticorpos e vacinas para serem utilizados no tratamento de cancros que expressam ror1 e inibição de metástases
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