ATE285472T1 - Glucagonrezeptoren - Google Patents
GlucagonrezeptorenInfo
- Publication number
- ATE285472T1 ATE285472T1 AT93920429T AT93920429T ATE285472T1 AT E285472 T1 ATE285472 T1 AT E285472T1 AT 93920429 T AT93920429 T AT 93920429T AT 93920429 T AT93920429 T AT 93920429T AT E285472 T1 ATE285472 T1 AT E285472T1
- Authority
- AT
- Austria
- Prior art keywords
- glucagon
- dna
- receptor
- compound
- glucagon receptor
- Prior art date
Links
- 108010063919 Glucagon Receptors Proteins 0.000 title abstract 5
- 102000051325 Glucagon Human genes 0.000 abstract 4
- 108060003199 Glucagon Proteins 0.000 abstract 4
- 102100040890 Glucagon receptor Human genes 0.000 abstract 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 4
- 229960004666 glucagon Drugs 0.000 abstract 4
- 230000037361 pathway Effects 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000005557 antagonist Substances 0.000 abstract 2
- 230000000638 stimulation Effects 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/605—Glucagons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93833192A | 1992-08-28 | 1992-08-28 | |
| US08/086,631 US5776725A (en) | 1992-08-28 | 1993-07-01 | Recombinant production of glucagon receptors |
| PCT/US1993/008174 WO1994005789A1 (en) | 1992-08-28 | 1993-08-30 | Glucagon receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE285472T1 true ATE285472T1 (de) | 2005-01-15 |
Family
ID=26774970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93920429T ATE285472T1 (de) | 1992-08-28 | 1993-08-30 | Glucagonrezeptoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5919635A (de) |
| EP (1) | EP0658200B1 (de) |
| JP (1) | JP3515112B2 (de) |
| AT (1) | ATE285472T1 (de) |
| AU (1) | AU689078B2 (de) |
| CA (1) | CA2142819C (de) |
| DE (1) | DE69333726T8 (de) |
| HU (1) | HU219674B (de) |
| NZ (1) | NZ255922A (de) |
| PL (1) | PL178685B1 (de) |
| RU (1) | RU2184779C2 (de) |
| WO (1) | WO1994005789A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994025591A1 (en) * | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| US6340588B1 (en) | 1995-04-25 | 2002-01-22 | Discovery Partners International, Inc. | Matrices with memories |
| DE69838067T2 (de) | 1997-05-23 | 2008-03-13 | Bioarray Solutions Ltd. | Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen |
| US6223560B1 (en) * | 1998-03-20 | 2001-05-01 | Cerocon S.A. | Process of producing a glassy product for multiple applications and products obtained by the process |
| US6608173B1 (en) * | 1998-04-04 | 2003-08-19 | Kenji Sakamoto | Method for searching physiologically active substances, process for producing these substances and drugs found by the searching method |
| DE60025829T2 (de) * | 1999-07-12 | 2006-11-02 | Genentech, Inc., South San Francisco | Expressionsvektoren und anwendungsmethoden |
| US20050005310A1 (en) * | 1999-07-12 | 2005-01-06 | Genentech, Inc. | Expression vectors and methods |
| US6909031B2 (en) * | 2000-12-06 | 2005-06-21 | Deltagen, Inc. | Transgenic mice containing glucagon receptor gene disruptions |
| US7399853B2 (en) * | 2003-04-28 | 2008-07-15 | Isis Pharmaceuticals | Modulation of glucagon receptor expression |
| US7750142B2 (en) | 2003-04-28 | 2010-07-06 | Isis Pharmaceuticals, Inc. | Modulation of glucagon receptor expression |
| US20050124550A1 (en) * | 2003-06-18 | 2005-06-09 | Peri Krishna G. | Compounds that modulate the glucagon response and uses thereof |
| EP2096170B1 (de) * | 2005-09-19 | 2011-08-10 | Isis Pharmaceuticals, Inc. | Modulation der Glucagonrezeptorexpression |
| JP5781308B2 (ja) * | 2008-02-19 | 2015-09-16 | バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ | 異種タンパク質を得る方法およびインスリン類似体 |
| AR070844A1 (es) * | 2008-03-27 | 2010-05-05 | Lilly Co Eli | Fragmento fab o anticuerpo monoclonal humanizado que comprende el fragmento fab, y su uso para la manufactura de un medicamento antagonista del polipeptido del receptor de glucagon para el tratamiento o prevencion de diabetes de tipo 1 o 2 |
| EP2475683A4 (de) * | 2009-09-08 | 2013-04-24 | Neopharm Co Ltd | Glucagonrezeptor-antikörper ihre verwendung |
| JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
| US8771696B2 (en) | 2010-11-23 | 2014-07-08 | Regeneron Pharmaceuticals, Inc. | Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor |
| EP2758533B1 (de) | 2011-09-20 | 2018-04-11 | Ionis Pharmaceuticals, Inc. | Antisense-modulation der gcgr-expression |
| CN105189560A (zh) | 2013-05-07 | 2015-12-23 | 瑞纳神经科学公司 | 抗胰高血糖素受体抗体和其使用方法 |
| SG10201913074WA (en) | 2016-08-30 | 2020-03-30 | Regeneron Pharma | Methods of treating severe insulin resistance by interfering with glucagon receptor signaling |
| WO2018075792A1 (en) | 2016-10-20 | 2018-04-26 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
| JP7005638B2 (ja) | 2017-01-27 | 2022-02-04 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | グルカゴン受容体結合タンパク質及びその使用方法 |
| US12139546B2 (en) | 2017-08-22 | 2024-11-12 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
| EP3829636A1 (de) | 2018-07-27 | 2021-06-09 | NGM Biopharmaceuticals, Inc. | Verwendung von glucagonrezeptor-antagonisten mit immunotherapeutika |
| JP7418788B2 (ja) * | 2019-10-16 | 2024-01-22 | 国立研究開発法人産業技術総合研究所 | グルカゴン認識ペプチド並びにグルカゴン検出法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430326A (en) * | 1981-12-22 | 1984-02-07 | University Patents, Inc. | Method of diminishing glucose levels resulting from endogenous glucagon |
| DE69209052T2 (de) * | 1991-01-17 | 1996-11-14 | Zymogenetics Inc | Verfahren zum nachweis von glucagon-antagonisten |
| DK39892D0 (da) * | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
-
1993
- 1993-08-30 JP JP50738094A patent/JP3515112B2/ja not_active Expired - Lifetime
- 1993-08-30 DE DE69333726T patent/DE69333726T8/de active Active
- 1993-08-30 WO PCT/US1993/008174 patent/WO1994005789A1/en not_active Ceased
- 1993-08-30 HU HU9500596A patent/HU219674B/hu unknown
- 1993-08-30 AU AU50974/93A patent/AU689078B2/en not_active Expired
- 1993-08-30 EP EP93920429A patent/EP0658200B1/de not_active Expired - Lifetime
- 1993-08-30 NZ NZ255922A patent/NZ255922A/en not_active IP Right Cessation
- 1993-08-30 AT AT93920429T patent/ATE285472T1/de not_active IP Right Cessation
- 1993-08-30 CA CA002142819A patent/CA2142819C/en not_active Expired - Lifetime
- 1993-08-30 PL PL93307746A patent/PL178685B1/pl unknown
- 1993-08-30 RU RU95106629/13A patent/RU2184779C2/ru active
-
1995
- 1995-05-30 US US08/452,930 patent/US5919635A/en not_active Expired - Lifetime
- 1995-05-30 US US08/453,956 patent/US5770445A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| RU2184779C2 (ru) | 2002-07-10 |
| AU5097493A (en) | 1994-03-29 |
| DE69333726T2 (de) | 2006-02-23 |
| EP0658200A1 (de) | 1995-06-21 |
| WO1994005789A1 (en) | 1994-03-17 |
| HU219674B (hu) | 2001-06-28 |
| PL178685B1 (pl) | 2000-06-30 |
| US5919635A (en) | 1999-07-06 |
| DE69333726D1 (de) | 2005-01-27 |
| NZ255922A (en) | 1998-01-26 |
| US5770445A (en) | 1998-06-23 |
| CA2142819A1 (en) | 1994-03-17 |
| AU689078B2 (en) | 1998-03-26 |
| DE69333726T8 (de) | 2006-04-27 |
| JPH08500737A (ja) | 1996-01-30 |
| CA2142819C (en) | 2003-08-19 |
| HUT74352A (en) | 1996-12-30 |
| HU9500596D0 (en) | 1995-04-28 |
| EP0658200B1 (de) | 2004-12-22 |
| PL307746A1 (en) | 1995-06-12 |
| RU95106629A (ru) | 1997-03-27 |
| JP3515112B2 (ja) | 2004-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |