PE20010516A1 - Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina - Google Patents

Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina

Info

Publication number
PE20010516A1
PE20010516A1 PE2000000852A PE0008522000A PE20010516A1 PE 20010516 A1 PE20010516 A1 PE 20010516A1 PE 2000000852 A PE2000000852 A PE 2000000852A PE 0008522000 A PE0008522000 A PE 0008522000A PE 20010516 A1 PE20010516 A1 PE 20010516A1
Authority
PE
Peru
Prior art keywords
somatostatin
compounds
somatostatin receptors
cyclic peptides
enhanced affinity
Prior art date
Application number
PE2000000852A
Other languages
English (en)
Inventor
Richard T Dean
David M Wilson
Daniel A Pearson
John Lister-James
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Publication of PE20010516A1 publication Critical patent/PE20010516A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE REFIERE A PEPTIDOS DE FORMULA CICLO-B1-B2-B3-B4-C-A; B1 ES PHE, TYR, NAL, AIN; B2 ES TRP; B3 ES LYS, HLY, ACHXA, AMF, AEC, APC, AES, APS; B4 ES THR, SER, VAL, PHE, ILE, ABU, NLE, LEU, NVA, AIB; C ES UN L-AMINOACIDO; A ES N-ALQUIL-AMINOACIDO COMO (N-CH3)Cys, (N-CH3)Hcy, ENTRE OTROS; A ES S, ESTA UNIDO A UN QUELANTE DE FORMULA b-Dap.Xaa.Cys.Zaa; Xaa ES UN L-AMINOACIDO, ETER AMINOETILICO, DE PREFERENCIA 1,4,7,10-TETRAAZACICLODECANO-1,4,7-TRIACETICO, ENTRE OTROS, LIGANTE DE METAL RADIOACTIVO, EL LIGANTE ES UNA FRACCION DE HIDRAZINONICOTINAMIDA, EL RADIOFARMACO ES 68Ga, 67Ga, 67Cu, 47Sc, 111In, 99mTc, 186Re, 188Re, 212Bi, 213Bi, 90Y, 64Cu, 153Sm, 94mTc, 166Ho, 223Ra, 225Ac, 18F, 125I, 131I, 123I, 211At. UN COMPUESTO PREFERIDO ES CICLO TYR-D-TRP-LYS-THR-PHE-(N-CH3)HCY(CH2CO-b-DAP-PHE(4-NH2)-CYS-THR-SER, ENTRE OTROS. LOS PEPTIDOS SON ANALOGOS DE SOMATOSTATINA CON AFINIDAD MEJORADA POR LOS RECEPTORES DE SOMATOSTATINA (SSTRs), POR LO QUE TIENEN UNA ALTA ABSORCION POR EL TUMOR
PE2000000852A 1999-08-27 2000-08-22 Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina PE20010516A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15100199P 1999-08-27 1999-08-27
US09/397,792 US6358491B1 (en) 1999-08-27 1999-09-16 Somatostatin analogs

Publications (1)

Publication Number Publication Date
PE20010516A1 true PE20010516A1 (es) 2001-04-29

Family

ID=26848228

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000852A PE20010516A1 (es) 1999-08-27 2000-08-22 Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina

Country Status (12)

Country Link
US (1) US6358491B1 (es)
EP (1) EP1208116B1 (es)
JP (1) JP2003517037A (es)
AT (1) ATE393781T1 (es)
AU (1) AU782873B2 (es)
CA (1) CA2383936A1 (es)
CO (1) CO5460266A1 (es)
DE (1) DE60038739T2 (es)
ES (1) ES2305000T3 (es)
PE (1) PE20010516A1 (es)
TW (1) TWI243178B (es)
WO (1) WO2001044177A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU749403B2 (en) * 1997-11-24 2002-06-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The Method to enhance tissue accumulation of radiolabeled compounds
EP1283216A1 (en) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use
DE10215336A1 (de) 2002-03-28 2003-10-23 Schering Ag N-Methyl-Homocysteine und ihre Verwendung sowie Verfahren zu ihrer Herstellung
US7189856B2 (en) * 2001-12-28 2007-03-13 Gideon Shapiro Non-peptide somatostatin receptor ligands
BRPI0414512B8 (pt) * 2003-09-17 2021-05-25 Board Of Regentes The Univ Of Texas System composição para reproduzir imagens de um pâncreas e uso desta
EP1700608A1 (en) 2005-03-10 2006-09-13 Schering AG Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
WO2006094725A1 (en) * 2005-03-10 2006-09-14 Bayer Schering Pharma Aktiengesellschaft Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
EP1717247A1 (en) * 2005-04-28 2006-11-02 Schering AG Cyclic peptides binding to the somatostatin receptor
EP1717219A1 (en) * 2005-04-28 2006-11-02 Schering AG Orthogonally protected bifunctional amino acid
WO2006114324A1 (en) * 2005-04-28 2006-11-02 Schering Ag Compounds comprising cyclized somatostatin receptor binding peptides
US20070025910A1 (en) 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
ES2351569B8 (es) * 2009-05-07 2012-06-20 Bcn Peptides S.A. Ligandos peptídicos de receptores de somatostatina.
RU2528414C1 (ru) * 2013-01-25 2014-09-20 Закрытое Акционерное Общество "Фарм-Синтез" Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы
US20160031935A1 (en) * 2013-03-15 2016-02-04 Adaerata, Limited Partnership Small molecule modulators of pcsk9 and methods of use thereof
KR102062025B1 (ko) 2014-06-30 2020-01-03 타베다 세라퓨틱스, 인코포레이티드 표적화된 콘주게이트 및 입자 및 그것의 제형
CA3001712A1 (en) 2015-10-28 2017-05-04 Tarveda Therapeutics, Inc. Sstr-targeted conjugates and particles and formulations thereof
PT3568205T (pt) 2017-01-12 2023-10-26 Radiomedix Inc Tratamento de células de cancro que sobrexpressam recetores de somatostatina com a utilização de derivados de ocreótido quelado a radioisótopos

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US4310518A (en) 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4486415A (en) 1983-08-15 1984-12-04 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4522813A (en) 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
EP0222578A3 (en) 1985-11-06 1990-04-04 Merck & Co. Inc. Use of cyclic somatostatin analogues in the treatment of immediate hypersensitivity diseases
US5776894A (en) 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5985240A (en) 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
SG93839A1 (en) * 1993-07-15 2003-01-21 Diatide Inc Radiolabeled peptides
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5597894A (en) 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
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AT405906B (de) 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie

Also Published As

Publication number Publication date
DE60038739T2 (de) 2009-05-20
EP1208116A2 (en) 2002-05-29
TWI243178B (en) 2005-11-11
EP1208116B1 (en) 2008-04-30
US6358491B1 (en) 2002-03-19
CA2383936A1 (en) 2001-06-21
JP2003517037A (ja) 2003-05-20
CO5460266A1 (es) 2004-11-30
ATE393781T1 (de) 2008-05-15
AU4865901A (en) 2001-06-25
AU782873B2 (en) 2005-09-08
WO2001044177A2 (en) 2001-06-21
DE60038739D1 (de) 2008-06-12
ES2305000T3 (es) 2008-11-01
WO2001044177A3 (en) 2002-03-28

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FD Application declared void or lapsed