EA200400816A1 - Замещенные аналоги хиназолин-4-иламина в качестве модуляторов капсаицина - Google Patents
Замещенные аналоги хиназолин-4-иламина в качестве модуляторов капсаицинаInfo
- Publication number
- EA200400816A1 EA200400816A1 EA200400816A EA200400816A EA200400816A1 EA 200400816 A1 EA200400816 A1 EA 200400816A1 EA 200400816 A EA200400816 A EA 200400816A EA 200400816 A EA200400816 A EA 200400816A EA 200400816 A1 EA200400816 A1 EA 200400816A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- capsaicin
- modulators
- hinazolin
- ilamine
- analogues
- Prior art date
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
В общем, данное изобретение относится к замещенным аналогам хиназолин-4-иламина, которые являются модуляторами капсаициновых рецепторов, и к применению таких соединений для лечения состояний, связанных с активацией капсаициновых рецепторов. Данное изобретение относится также к использованию таких соединений в качестве зондов для детектирования и локализирования капсаициновых рецепторов.Отчет о международном поиске был опубликован 2003.09.04.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34992002P | 2002-01-17 | 2002-01-17 | |
US35052702P | 2002-01-22 | 2002-01-22 | |
PCT/US2003/001563 WO2003062209A2 (en) | 2002-01-17 | 2003-01-17 | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200400816A1 true EA200400816A1 (ru) | 2005-02-24 |
Family
ID=27616757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400816A EA200400816A1 (ru) | 2002-01-17 | 2003-01-17 | Замещенные аналоги хиназолин-4-иламина в качестве модуляторов капсаицина |
Country Status (15)
Country | Link |
---|---|
US (3) | US7074799B2 (ru) |
EP (1) | EP1471910A2 (ru) |
JP (1) | JP2005526714A (ru) |
KR (1) | KR20040085151A (ru) |
CN (1) | CN1627944A (ru) |
BR (1) | BR0306982A (ru) |
CA (1) | CA2473796A1 (ru) |
EA (1) | EA200400816A1 (ru) |
HU (1) | HUP0500200A2 (ru) |
MX (1) | MXPA04006882A (ru) |
NO (1) | NO20043411L (ru) |
PL (1) | PL371587A1 (ru) |
RS (1) | RS63204A (ru) |
TW (1) | TW200406390A (ru) |
WO (1) | WO2003062209A2 (ru) |
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BR0112631A (pt) * | 2000-07-20 | 2003-09-23 | Neurogen Corp | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, pacote, métodos de reduzir a condutáncia de cálcio de um receptor de capsaicina e de tratar um mamìfero e uso de um composto |
DK1472225T3 (da) | 2002-02-01 | 2010-08-09 | Euro Celtique Sa | 2-Piperazinpyridiner, som er anvendelige til behandling af smerte |
US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
ATE533743T1 (de) | 2002-05-17 | 2011-12-15 | Janssen Pharmaceutica Nv | Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1 |
CA2485343A1 (en) * | 2002-05-23 | 2004-05-13 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
RS114804A (en) | 2002-06-28 | 2006-12-15 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
CN1726205A (zh) | 2002-12-13 | 2006-01-25 | 神经能质公司 | 作为辣椒素受体调节剂的2-取代的喹唑啉-4-基胺类似物 |
WO2004054582A1 (en) * | 2002-12-13 | 2004-07-01 | Neurogen Corporation | Combination therapy for the treatment of pain |
GB0229808D0 (en) * | 2002-12-20 | 2003-01-29 | Glaxo Group Ltd | Novel compositions |
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MXPA05010882A (es) * | 2003-04-08 | 2005-11-25 | Algorx Pharmaceuticals Inc | Preparacion y purificacion de capsaicina sintetica. |
GB0310726D0 (en) * | 2003-05-09 | 2003-06-11 | Merck Sharp & Dohme | Therapeutic agents |
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DE602004007141T2 (de) * | 2003-07-10 | 2007-10-11 | Neurogen Corp., Branford | Aryl-substituierte Benzo(D)isothiazol-3-Ylamin Analoga als Capsaicinrezeptormodulatoren |
TW200510373A (en) | 2003-07-14 | 2005-03-16 | Neurogen Corp | Substituted quinolin-4-ylamine analogues |
US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
JP2007520444A (ja) * | 2003-09-09 | 2007-07-26 | ニューロジェン・コーポレーション | 置換二環式キナゾリン−4−イルアミン誘導体 |
JP2007509985A (ja) * | 2003-10-31 | 2007-04-19 | ニューロジェン・コーポレーション | カプサイシン受容体作動薬 |
CA2545340A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Fused heterocyclic compounds |
US20050165032A1 (en) * | 2004-01-23 | 2005-07-28 | Norman Mark H. | Vanilloid receptor ligands and their use in treatments |
GB0403819D0 (en) * | 2004-02-20 | 2004-03-24 | Merck Sharp & Dohme | New compounds |
JP2007526323A (ja) * | 2004-03-04 | 2007-09-13 | ニューロジェン・コーポレーション | アリールアルキルアミノ置換キナゾリン類縁体 |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
WO2005099710A1 (en) * | 2004-04-08 | 2005-10-27 | Neurogen Corporation | Substituted cinnolin-4-ylamines |
WO2006007851A2 (en) | 2004-07-19 | 2006-01-26 | Novo Nordisk A/S | Capsaicin inhibitors for treating obesity and-related disorders |
AR050948A1 (es) * | 2004-09-24 | 2006-12-06 | Hoffmann La Roche | Derivados de ftalazinona; su obtencion y su utilizacion en la fabricacion de medicamentos para el tratamiento del cancer. |
TW200621251A (en) | 2004-10-12 | 2006-07-01 | Neurogen Corp | Substituted biaryl quinolin-4-ylamine analogues |
US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
GB0428475D0 (en) * | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
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- 2003-01-17 HU HU0500200A patent/HUP0500200A2/hu unknown
- 2003-01-17 EA EA200400816A patent/EA200400816A1/ru unknown
- 2003-01-17 BR BR0306982-6A patent/BR0306982A/pt not_active IP Right Cessation
- 2003-01-17 CA CA002473796A patent/CA2473796A1/en not_active Abandoned
- 2003-01-17 MX MXPA04006882A patent/MXPA04006882A/es unknown
- 2003-01-17 RS YU63204A patent/RS63204A/sr unknown
- 2003-01-17 EP EP03703887A patent/EP1471910A2/en not_active Withdrawn
- 2003-01-17 WO PCT/US2003/001563 patent/WO2003062209A2/en active Application Filing
- 2003-01-17 PL PL03371587A patent/PL371587A1/xx not_active Application Discontinuation
- 2003-01-17 CN CNA038024527A patent/CN1627944A/zh active Pending
- 2003-01-17 TW TW092100991A patent/TW200406390A/zh unknown
- 2003-01-17 JP JP2003562090A patent/JP2005526714A/ja not_active Withdrawn
- 2003-01-21 US US10/347,210 patent/US7074799B2/en not_active Expired - Lifetime
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- 2004-08-16 NO NO20043411A patent/NO20043411L/no unknown
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2006
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2007
- 2007-09-29 US US11/864,987 patent/US20080015183A1/en not_active Abandoned
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CA2473796A1 (en) | 2003-07-31 |
WO2003062209A2 (en) | 2003-07-31 |
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JP2005526714A (ja) | 2005-09-08 |
HUP0500200A2 (hu) | 2005-07-28 |
WO2003062209A3 (en) | 2003-09-04 |
US20040106616A1 (en) | 2004-06-03 |
NO20043411L (no) | 2004-09-24 |
US20060173003A1 (en) | 2006-08-03 |
BR0306982A (pt) | 2004-10-26 |
US20080015183A1 (en) | 2008-01-17 |
CN1627944A (zh) | 2005-06-15 |
PL371587A1 (en) | 2005-06-27 |
MXPA04006882A (es) | 2004-12-06 |
US7304059B2 (en) | 2007-12-04 |
EP1471910A2 (en) | 2004-11-03 |
KR20040085151A (ko) | 2004-10-07 |
US7074799B2 (en) | 2006-07-11 |
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