BRPI0414634A - agonistas de receptor b2, adrenérgico de etilamino amino-substituìdo - Google Patents

agonistas de receptor b2, adrenérgico de etilamino amino-substituìdo

Info

Publication number
BRPI0414634A
BRPI0414634A BRPI0414634-4A BRPI0414634A BRPI0414634A BR PI0414634 A BRPI0414634 A BR PI0414634A BR PI0414634 A BRPI0414634 A BR PI0414634A BR PI0414634 A BRPI0414634 A BR PI0414634A
Authority
BR
Brazil
Prior art keywords
adrenergic
receptor agonists
compounds
amino substituted
ethylamino
Prior art date
Application number
BRPI0414634-4A
Other languages
English (en)
Inventor
Martin Linsell
John R Jacobsen
Daisuke Roland Saito
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of BRPI0414634A publication Critical patent/BRPI0414634A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Abstract

"AGONISTAS DE RECEPTOR <225>~ 2~ ADRENéRGICO DE ETILAMINO AMINO-SUBSTITUìDO". A invenção fornece novos compostos agonistas de receptor <225>~ 2~ adrenérgico. A invenção também fornece composições farmacêuticas que compreendem tais compostos, métodos de uso de tais compostos para tratar doenças associadas a atividade de receptor <225>~ 2~ adrenérgico, e processos e intermediários úteis para a preparação de tais compostos.
BRPI0414634-4A 2003-09-22 2004-09-21 agonistas de receptor b2, adrenérgico de etilamino amino-substituìdo BRPI0414634A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50568503P 2003-09-22 2003-09-22
PCT/US2004/030833 WO2005030678A2 (en) 2003-09-22 2004-09-21 AMINO-SUBSTITUTED ETHYLAMINO β2 ADRENERGIC RECEPTOR AGONISTS

Publications (1)

Publication Number Publication Date
BRPI0414634A true BRPI0414634A (pt) 2006-11-07

Family

ID=34393055

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414634-4A BRPI0414634A (pt) 2003-09-22 2004-09-21 agonistas de receptor b2, adrenérgico de etilamino amino-substituìdo

Country Status (28)

Country Link
US (2) US7399863B2 (pt)
EP (1) EP1687257B1 (pt)
JP (1) JP2007505931A (pt)
KR (1) KR20070015496A (pt)
CN (1) CN100465158C (pt)
AR (1) AR046085A1 (pt)
AT (1) ATE428685T1 (pt)
AU (1) AU2004276254A1 (pt)
BR (1) BRPI0414634A (pt)
CA (1) CA2538037A1 (pt)
CO (1) CO5680412A2 (pt)
DE (1) DE602004020655D1 (pt)
DK (1) DK1687257T3 (pt)
ES (1) ES2326172T3 (pt)
HK (1) HK1093486A1 (pt)
IL (1) IL174026A0 (pt)
IS (1) IS8346A (pt)
MA (1) MA28089A1 (pt)
MX (1) MXPA06003093A (pt)
NO (1) NO20061737L (pt)
NZ (1) NZ545764A (pt)
PL (1) PL1687257T3 (pt)
PT (1) PT1687257E (pt)
RU (1) RU2385317C2 (pt)
SI (1) SI1687257T1 (pt)
TW (1) TW200526547A (pt)
WO (1) WO2005030678A2 (pt)
ZA (1) ZA200602308B (pt)

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AU2005252226A1 (en) * 2004-06-03 2005-12-22 Theravance, Inc. Diamine beta2 adrenergic receptor agonists
EP1778638A1 (en) * 2004-07-21 2007-05-02 Theravance, Inc. Diaryl ether beta2 adrenergic receptor agonists
US7566785B2 (en) * 2004-09-10 2009-07-28 Theravance, Inc. Amidine substituted aryl aniline compounds
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CN102124003A (zh) 2008-06-18 2011-07-13 阿斯利康(瑞典)有限公司 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物
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CN112645875A (zh) * 2020-12-09 2021-04-13 深圳海王医药科技研究院有限公司 一种盐酸丙卡特罗杂质的制备方法

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Also Published As

Publication number Publication date
JP2007505931A (ja) 2007-03-15
CA2538037A1 (en) 2005-04-07
HK1093486A1 (en) 2007-03-02
CO5680412A2 (es) 2006-09-29
SI1687257T1 (sl) 2009-10-31
IL174026A0 (en) 2006-08-01
ES2326172T3 (es) 2009-10-02
AU2004276254A1 (en) 2005-04-07
CN1856465A (zh) 2006-11-01
RU2385317C2 (ru) 2010-03-27
MXPA06003093A (es) 2006-06-20
ATE428685T1 (de) 2009-05-15
EP1687257A2 (en) 2006-08-09
NZ545764A (en) 2009-12-24
AR046085A1 (es) 2005-11-23
KR20070015496A (ko) 2007-02-05
WO2005030678A3 (en) 2005-05-26
US20050113411A1 (en) 2005-05-26
ZA200602308B (en) 2007-07-25
EP1687257B1 (en) 2009-04-15
PT1687257E (pt) 2009-05-28
CN100465158C (zh) 2009-03-04
US20090111850A1 (en) 2009-04-30
US7399863B2 (en) 2008-07-15
DK1687257T3 (da) 2009-07-20
NO20061737L (no) 2006-05-31
US7964730B2 (en) 2011-06-21
TW200526547A (en) 2005-08-16
RU2006113700A (ru) 2006-09-10
DE602004020655D1 (de) 2009-05-28
MA28089A1 (fr) 2006-08-01
PL1687257T3 (pl) 2009-09-30
IS8346A (is) 2006-03-09
WO2005030678A2 (en) 2005-04-07

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.