BRPI0608392A2 - compostos de quinolinona como agonistas do receptor 5-ht4 - Google Patents
compostos de quinolinona como agonistas do receptor 5-ht4Info
- Publication number
- BRPI0608392A2 BRPI0608392A2 BRPI0608392-7A BRPI0608392A BRPI0608392A2 BR PI0608392 A2 BRPI0608392 A2 BR PI0608392A2 BR PI0608392 A BRPI0608392 A BR PI0608392A BR PI0608392 A2 BRPI0608392 A2 BR PI0608392A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- receptor agonists
- quinolinone
- quinolinone compounds
- receptor
- Prior art date
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title abstract 4
- 239000000018 receptor agonist Substances 0.000 title abstract 3
- 229940044601 receptor agonist Drugs 0.000 title abstract 3
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229930185107 quinolinone Natural products 0.000 abstract 1
- -1 quinolinone carboxamide Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPOSTOS DE QUINOLINONA COMO AGONISTAS DO RECEPTOR 5-HT4. A invenção proporciona novos compostos agonistas do receptor 5-HT4 de quinolinona-carboxamida. A invenção também proporciona composições farmacêuticas compreendendo tais compostos, métodos de uso de tais compostos para tratar doenças associada à atividade do receptor 5-HT4 e processos e intermediários úteis para o preparo de tais compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65800705P | 2005-03-02 | 2005-03-02 | |
PCT/US2006/007284 WO2006094063A1 (en) | 2005-03-02 | 2006-03-01 | Quinolinone compounds as 5-ht4 receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0608392A2 true BRPI0608392A2 (pt) | 2009-12-29 |
Family
ID=36588769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0608392-7A BRPI0608392A2 (pt) | 2005-03-02 | 2006-03-01 | compostos de quinolinona como agonistas do receptor 5-ht4 |
Country Status (16)
Country | Link |
---|---|
US (2) | US7446114B2 (pt) |
EP (1) | EP1871772B1 (pt) |
JP (1) | JP5042043B2 (pt) |
KR (1) | KR20070107807A (pt) |
CN (1) | CN101163701A (pt) |
AU (1) | AU2006218603A1 (pt) |
BR (1) | BRPI0608392A2 (pt) |
CA (1) | CA2599404A1 (pt) |
EA (1) | EA013567B1 (pt) |
ES (1) | ES2523851T3 (pt) |
IL (1) | IL185407A0 (pt) |
MX (1) | MX2007010769A (pt) |
NO (1) | NO20074884L (pt) |
NZ (1) | NZ560828A (pt) |
WO (1) | WO2006094063A1 (pt) |
ZA (1) | ZA200707142B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
TWI377206B (en) * | 2005-04-06 | 2012-11-21 | Theravance Inc | Crystalline form of a quinolinone-carboxamide compound |
MY143574A (en) * | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
WO2008102720A1 (ja) * | 2007-02-19 | 2008-08-28 | Kaneka Corporation | 光学活性3-アミノピペリジン又はその塩の製造方法 |
JP5540099B2 (ja) * | 2009-09-14 | 2014-07-02 | スベン ライフ サイエンシズ リミティド | 5−ht4受容体リガンドとしての1,2−ジヒドロ−2−オキソキノリン化合物 |
RS60074B1 (sr) * | 2015-04-02 | 2020-05-29 | Theravance Biopharma R&D Ip Llc | Kombinovani oblik doze antagonista mu opioidnog receptora i opioidni agens |
WO2023135508A1 (en) | 2022-01-11 | 2023-07-20 | Suven Life Sciences Limited | PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS |
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KR100875558B1 (ko) * | 2004-06-15 | 2008-12-23 | 화이자 인코포레이티드 | 벤즈이미다졸론 카복실산 유도체 |
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JP5042028B2 (ja) | 2004-11-05 | 2012-10-03 | セラヴァンス, インコーポレーテッド | キノリノン−カルボキサミド化合物 |
ATE441646T1 (de) | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
ATE469897T1 (de) * | 2004-12-22 | 2010-06-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
US7317022B2 (en) * | 2005-06-07 | 2008-01-08 | Theravance, Inc. | Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists |
MY143574A (en) * | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
-
2006
- 2006-03-01 ES ES06736578.3T patent/ES2523851T3/es active Active
- 2006-03-01 CA CA002599404A patent/CA2599404A1/en not_active Abandoned
- 2006-03-01 JP JP2007558181A patent/JP5042043B2/ja not_active Expired - Fee Related
- 2006-03-01 MX MX2007010769A patent/MX2007010769A/es active IP Right Grant
- 2006-03-01 CN CNA2006800131887A patent/CN101163701A/zh active Pending
- 2006-03-01 WO PCT/US2006/007284 patent/WO2006094063A1/en active Application Filing
- 2006-03-01 US US11/365,320 patent/US7446114B2/en active Active
- 2006-03-01 AU AU2006218603A patent/AU2006218603A1/en not_active Abandoned
- 2006-03-01 BR BRPI0608392-7A patent/BRPI0608392A2/pt not_active IP Right Cessation
- 2006-03-01 NZ NZ560828A patent/NZ560828A/en not_active IP Right Cessation
- 2006-03-01 EP EP06736578.3A patent/EP1871772B1/en active Active
- 2006-03-01 EA EA200701867A patent/EA013567B1/ru not_active IP Right Cessation
- 2006-03-01 KR KR1020077022429A patent/KR20070107807A/ko not_active Application Discontinuation
-
2007
- 2007-08-21 IL IL185407A patent/IL185407A0/en unknown
- 2007-08-23 ZA ZA200707142A patent/ZA200707142B/xx unknown
- 2007-09-25 NO NO20074884A patent/NO20074884L/no not_active Application Discontinuation
-
2008
- 2008-09-22 US US12/234,906 patent/US7875629B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20060199839A1 (en) | 2006-09-07 |
AU2006218603A1 (en) | 2006-09-08 |
EP1871772B1 (en) | 2014-09-10 |
NZ560828A (en) | 2011-01-28 |
EP1871772A1 (en) | 2008-01-02 |
WO2006094063A1 (en) | 2006-09-08 |
EA200701867A1 (ru) | 2008-02-28 |
CA2599404A1 (en) | 2006-09-08 |
US20090036483A1 (en) | 2009-02-05 |
MX2007010769A (es) | 2008-03-07 |
ES2523851T3 (es) | 2014-12-02 |
US7875629B2 (en) | 2011-01-25 |
US7446114B2 (en) | 2008-11-04 |
KR20070107807A (ko) | 2007-11-07 |
EA013567B1 (ru) | 2010-06-30 |
ZA200707142B (en) | 2008-10-29 |
JP2008531711A (ja) | 2008-08-14 |
IL185407A0 (en) | 2008-01-06 |
NO20074884L (no) | 2007-11-29 |
JP5042043B2 (ja) | 2012-10-03 |
CN101163701A (zh) | 2008-04-16 |
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