EA200701705A1 - Антагонисты рецепторы глюкагона, получение и терапевтическое применение - Google Patents

Антагонисты рецепторы глюкагона, получение и терапевтическое применение

Info

Publication number
EA200701705A1
EA200701705A1 EA200701705A EA200701705A EA200701705A1 EA 200701705 A1 EA200701705 A1 EA 200701705A1 EA 200701705 A EA200701705 A EA 200701705A EA 200701705 A EA200701705 A EA 200701705A EA 200701705 A1 EA200701705 A1 EA 200701705A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
antagonists
obtaining
methods
therapeutic application
Prior art date
Application number
EA200701705A
Other languages
English (en)
Inventor
Марк Дональд Чэппелл
Скотт Юджин Коннер
Элли Эдвард Трипп
Госинь Чжу
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36694345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200701705(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200701705A1 publication Critical patent/EA200701705A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Данное изобретение раскрывает новые соединения формулы Iили их фармацевтически приемлемые соли, которые обладают активностью антагониста или обратного агониста рецептора глюкагона, способы применения данных соединений и промежуточных соединений, а также способы получения этих соединений. В другом варианте изобретение раскрывает фармацевтические композиции, содержащие соединения формулы I, а также способы их применения для лечения диабетических или других связанных с глюкагоном метаболических нарушений и т.п.
EA200701705A 2005-02-11 2006-02-09 Антагонисты рецепторы глюкагона, получение и терапевтическое применение EA200701705A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65249205P 2005-02-11 2005-02-11
PCT/US2006/004461 WO2006086488A2 (en) 2005-02-11 2006-02-09 Substituted thiophene derivatives as glucagon receptor antagonists, preparation and therapeutic uses

Publications (1)

Publication Number Publication Date
EA200701705A1 true EA200701705A1 (ru) 2008-02-28

Family

ID=36694345

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701705A EA200701705A1 (ru) 2005-02-11 2006-02-09 Антагонисты рецепторы глюкагона, получение и терапевтическое применение

Country Status (25)

Country Link
US (1) US8084489B2 (ru)
EP (1) EP1856090B1 (ru)
JP (1) JP4988604B2 (ru)
KR (1) KR20070104409A (ru)
CN (1) CN101115735B (ru)
AT (1) ATE445609T1 (ru)
AU (1) AU2006213894B2 (ru)
BR (1) BRPI0607015A2 (ru)
CA (1) CA2597073C (ru)
CR (1) CR9304A (ru)
CY (1) CY1109624T1 (ru)
DE (1) DE602006009773D1 (ru)
DK (1) DK1856090T3 (ru)
EA (1) EA200701705A1 (ru)
ES (1) ES2332470T3 (ru)
IL (1) IL184932A0 (ru)
MA (1) MA29432B1 (ru)
MX (1) MX2007009661A (ru)
NO (1) NO20074567L (ru)
PL (1) PL1856090T3 (ru)
PT (1) PT1856090E (ru)
SI (1) SI1856090T1 (ru)
TN (1) TNSN07313A1 (ru)
WO (1) WO2006086488A2 (ru)
ZA (1) ZA200706354B (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06014426A (es) * 2004-06-14 2007-03-01 Lilly Co Eli Antagonistas del receptor de glucagon, preparacion y usos therapeuticos.
WO2008098244A1 (en) 2007-02-09 2008-08-14 Metabasis Therapeutics, Inc. Novel antagonists of the glucagon receptor
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2966273C (en) 2008-08-13 2019-08-27 Metabasis Therapeutics, Inc. Glucagon antagonists
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
NZ611529A (en) 2010-12-23 2015-06-26 Pfizer Glucagon receptor modulators
CN104744370A (zh) 2011-02-08 2015-07-01 辉瑞大药厂 胰高血糖素受体调节剂
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
BR112014000288A2 (pt) 2011-07-22 2017-01-10 Pfizer moduladores do receptor de glucagon de quinolinila
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
TW201427658A (zh) 2012-12-10 2014-07-16 Merck Sharp & Dohme 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
EP3065736B1 (en) 2013-11-04 2018-11-14 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions thereof, and methods of use
US10076504B2 (en) 2014-06-12 2018-09-18 Ligand Pharmaceuticals, Inc. Glucagon antagonists
CA2998862A1 (en) 2015-09-18 2017-03-23 Wake Forest University Health Sciences Angiotensin (1-7) analogs and methods relating thereto
CA2914601A1 (en) * 2015-12-11 2017-06-11 Wake Forest University Health Sciences Angiotensin-(1-7) analogs and methods relating thereto
EP3506940A1 (en) 2016-08-30 2019-07-10 Regeneron Pharmaceuticals, Inc. Methods of treating severe insulin resistance by interfering with glucagon receptor signaling
EP3529278A1 (en) 2016-10-20 2019-08-28 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
CA3071387A1 (en) 2017-08-22 2019-02-28 Regeneron Pharmaceuticals, Inc. Methods of treating urea cycle disorders by interfering with glucagon receptor signaling
US20210121422A1 (en) 2018-02-13 2021-04-29 Ligand Pharmaceuticals Incorporated Glucagon receptor antagonists
EP4285723A3 (en) 2019-12-20 2024-03-27 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002365622A1 (en) * 2001-12-03 2003-06-17 Novo Nordisk A/S Novel glucagon antagonists
EP1519723A1 (en) 2002-06-27 2005-04-06 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
WO2005118542A1 (en) * 2004-05-28 2005-12-15 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
MXPA06014426A (es) 2004-06-14 2007-03-01 Lilly Co Eli Antagonistas del receptor de glucagon, preparacion y usos therapeuticos.

Also Published As

Publication number Publication date
WO2006086488A2 (en) 2006-08-17
US8084489B2 (en) 2011-12-27
AU2006213894B2 (en) 2011-12-08
NO20074567L (no) 2007-11-08
JP4988604B2 (ja) 2012-08-01
CA2597073C (en) 2014-11-25
DK1856090T3 (da) 2009-11-30
IL184932A0 (en) 2007-12-03
ES2332470T3 (es) 2010-02-05
SI1856090T1 (sl) 2010-02-26
MX2007009661A (es) 2007-09-25
CY1109624T1 (el) 2014-08-13
KR20070104409A (ko) 2007-10-25
TNSN07313A1 (en) 2008-12-31
CR9304A (es) 2008-03-31
WO2006086488A3 (en) 2006-12-14
EP1856090A2 (en) 2007-11-21
BRPI0607015A2 (pt) 2009-12-01
ATE445609T1 (de) 2009-10-15
US20100137417A1 (en) 2010-06-03
MA29432B1 (fr) 2008-05-02
AU2006213894A1 (en) 2006-08-17
EP1856090B1 (en) 2009-10-14
PL1856090T3 (pl) 2010-02-26
ZA200706354B (en) 2008-11-26
CN101115735B (zh) 2013-01-09
CN101115735A (zh) 2008-01-30
PT1856090E (pt) 2009-11-18
DE602006009773D1 (de) 2009-11-26
CA2597073A1 (en) 2006-08-17
JP2008530102A (ja) 2008-08-07

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