NO20074567L - Glucagonreseptorantagoniser, fremstilling og terapeutisk anvendelse - Google Patents
Glucagonreseptorantagoniser, fremstilling og terapeutisk anvendelseInfo
- Publication number
- NO20074567L NO20074567L NO20074567A NO20074567A NO20074567L NO 20074567 L NO20074567 L NO 20074567L NO 20074567 A NO20074567 A NO 20074567A NO 20074567 A NO20074567 A NO 20074567A NO 20074567 L NO20074567 L NO 20074567L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- glucagon receptor
- preparation
- methods
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Foreliggende oppfinnelse beskriver nye forbindelser med formel I eller farmasøytisk akseptable salter derav som har glukagon reseptorantagonist eller invers-agonistisk aktivitet, så vel som fremgangsmåter for anvendelse av disse forbindelsene og intermediatene og fremgangsmåter for fremstilling av slike forbindelser. I en annen utførelsesform beskriver foreliggende oppfinnelse farmasøytiske sammensetninger som innbefatter forbindelser med formel I så vel som fremgangsmåter for anvendelse av dem for behandling av diabetiske og andre glukagonrelaterte metabolske forstyrrelser, og lignende.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65249205P | 2005-02-11 | 2005-02-11 | |
PCT/US2006/004461 WO2006086488A2 (en) | 2005-02-11 | 2006-02-09 | Substituted thiophene derivatives as glucagon receptor antagonists, preparation and therapeutic uses |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20074567L true NO20074567L (no) | 2007-11-08 |
Family
ID=36694345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20074567A NO20074567L (no) | 2005-02-11 | 2007-09-10 | Glucagonreseptorantagoniser, fremstilling og terapeutisk anvendelse |
Country Status (25)
Country | Link |
---|---|
US (1) | US8084489B2 (no) |
EP (1) | EP1856090B1 (no) |
JP (1) | JP4988604B2 (no) |
KR (1) | KR20070104409A (no) |
CN (1) | CN101115735B (no) |
AT (1) | ATE445609T1 (no) |
AU (1) | AU2006213894B2 (no) |
BR (1) | BRPI0607015A2 (no) |
CA (1) | CA2597073C (no) |
CR (1) | CR9304A (no) |
CY (1) | CY1109624T1 (no) |
DE (1) | DE602006009773D1 (no) |
DK (1) | DK1856090T3 (no) |
EA (1) | EA200701705A1 (no) |
ES (1) | ES2332470T3 (no) |
IL (1) | IL184932A0 (no) |
MA (1) | MA29432B1 (no) |
MX (1) | MX2007009661A (no) |
NO (1) | NO20074567L (no) |
PL (1) | PL1856090T3 (no) |
PT (1) | PT1856090E (no) |
SI (1) | SI1856090T1 (no) |
TN (1) | TNSN07313A1 (no) |
WO (1) | WO2006086488A2 (no) |
ZA (1) | ZA200706354B (no) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0512058A (pt) * | 2004-06-14 | 2008-02-06 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto |
CN105566265A (zh) | 2007-02-09 | 2016-05-11 | 症变治疗公司 | 新颖的胰高血糖素受体拮抗剂 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
ES2714207T3 (es) | 2008-08-13 | 2019-05-27 | Metabasis Therapeutics Inc | Antagonistas de glucagón |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
AU2011346670B2 (en) | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
DK2673260T3 (en) | 2011-02-08 | 2016-10-10 | Pfizer | Glucagonreceptormodulator |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
BR112014000288A2 (pt) | 2011-07-22 | 2017-01-10 | Pfizer | moduladores do receptor de glucagon de quinolinila |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
TW201427658A (zh) | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
JP2017519000A (ja) | 2014-06-12 | 2017-07-13 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴンアンタゴニスト |
EP3350200A4 (en) | 2015-09-18 | 2019-03-27 | Wake Forest University Health Services | ANGIOTENSIN ANALOGUES (1-7) AND ASSOCIATED METHODS |
CA2914601A1 (en) * | 2015-12-11 | 2017-06-11 | Wake Forest University Health Sciences | Angiotensin-(1-7) analogs and methods relating thereto |
EP3506940A1 (en) | 2016-08-30 | 2019-07-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating severe insulin resistance by interfering with glucagon receptor signaling |
US20190248888A1 (en) | 2016-10-20 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
JP2020531532A (ja) | 2017-08-22 | 2020-11-05 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体シグナル伝達に干渉することによって尿素サイクル異常症を治療する方法 |
US20210121422A1 (en) | 2018-02-13 | 2021-04-29 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
WO2021123051A1 (en) | 2019-12-20 | 2021-06-24 | Bayer Aktiengesellschaft | Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1463715A1 (en) * | 2001-12-03 | 2004-10-06 | Novo Nordisk A/S | Novel glucagon antagonists |
AU2003233780A1 (en) * | 2002-06-27 | 2004-01-19 | Novo Nordisk A/S | Novel glucagon antagonists/inverse agonists |
US7989457B2 (en) * | 2004-05-28 | 2011-08-02 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
BRPI0512058A (pt) | 2004-06-14 | 2008-02-06 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto |
-
2006
- 2006-02-09 WO PCT/US2006/004461 patent/WO2006086488A2/en active Application Filing
- 2006-02-09 PL PL06720513T patent/PL1856090T3/pl unknown
- 2006-02-09 BR BRPI0607015-9A patent/BRPI0607015A2/pt not_active IP Right Cessation
- 2006-02-09 EP EP06720513A patent/EP1856090B1/en active Active
- 2006-02-09 ES ES06720513T patent/ES2332470T3/es active Active
- 2006-02-09 DE DE602006009773T patent/DE602006009773D1/de active Active
- 2006-02-09 JP JP2007555195A patent/JP4988604B2/ja not_active Expired - Fee Related
- 2006-02-09 CA CA2597073A patent/CA2597073C/en not_active Expired - Fee Related
- 2006-02-09 PT PT06720513T patent/PT1856090E/pt unknown
- 2006-02-09 EA EA200701705A patent/EA200701705A1/ru unknown
- 2006-02-09 DK DK06720513T patent/DK1856090T3/da active
- 2006-02-09 AU AU2006213894A patent/AU2006213894B2/en not_active Ceased
- 2006-02-09 KR KR1020077018437A patent/KR20070104409A/ko not_active Application Discontinuation
- 2006-02-09 CN CN2006800046189A patent/CN101115735B/zh not_active Expired - Fee Related
- 2006-02-09 AT AT06720513T patent/ATE445609T1/de active
- 2006-02-09 US US11/815,987 patent/US8084489B2/en not_active Expired - Fee Related
- 2006-02-09 SI SI200630534T patent/SI1856090T1/sl unknown
- 2006-02-09 MX MX2007009661A patent/MX2007009661A/es active IP Right Grant
-
2007
- 2007-07-30 IL IL184932A patent/IL184932A0/en unknown
- 2007-07-31 ZA ZA200706354A patent/ZA200706354B/xx unknown
- 2007-08-10 TN TNP2007000313A patent/TNSN07313A1/en unknown
- 2007-08-10 CR CR9304A patent/CR9304A/es not_active Application Discontinuation
- 2007-09-10 NO NO20074567A patent/NO20074567L/no not_active Application Discontinuation
- 2007-09-11 MA MA30221A patent/MA29432B1/fr unknown
-
2009
- 2009-11-12 CY CY20091101192T patent/CY1109624T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2597073A1 (en) | 2006-08-17 |
PT1856090E (pt) | 2009-11-18 |
IL184932A0 (en) | 2007-12-03 |
DE602006009773D1 (de) | 2009-11-26 |
TNSN07313A1 (en) | 2008-12-31 |
ZA200706354B (en) | 2008-11-26 |
WO2006086488A2 (en) | 2006-08-17 |
CA2597073C (en) | 2014-11-25 |
JP2008530102A (ja) | 2008-08-07 |
ES2332470T3 (es) | 2010-02-05 |
DK1856090T3 (da) | 2009-11-30 |
AU2006213894A1 (en) | 2006-08-17 |
PL1856090T3 (pl) | 2010-02-26 |
CN101115735A (zh) | 2008-01-30 |
CN101115735B (zh) | 2013-01-09 |
US20100137417A1 (en) | 2010-06-03 |
EP1856090B1 (en) | 2009-10-14 |
MA29432B1 (fr) | 2008-05-02 |
ATE445609T1 (de) | 2009-10-15 |
CR9304A (es) | 2008-03-31 |
EA200701705A1 (ru) | 2008-02-28 |
SI1856090T1 (sl) | 2010-02-26 |
BRPI0607015A2 (pt) | 2009-12-01 |
CY1109624T1 (el) | 2014-08-13 |
JP4988604B2 (ja) | 2012-08-01 |
EP1856090A2 (en) | 2007-11-21 |
AU2006213894B2 (en) | 2011-12-08 |
WO2006086488A3 (en) | 2006-12-14 |
MX2007009661A (es) | 2007-09-25 |
KR20070104409A (ko) | 2007-10-25 |
US8084489B2 (en) | 2011-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |