EA200500520A1 - Пуриновые соединения и их применение в качестве лигандов каннабиноидных рецепторов - Google Patents

Пуриновые соединения и их применение в качестве лигандов каннабиноидных рецепторов

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Publication number
EA200500520A1
EA200500520A1 EA200500520A EA200500520A EA200500520A1 EA 200500520 A1 EA200500520 A1 EA 200500520A1 EA 200500520 A EA200500520 A EA 200500520A EA 200500520 A EA200500520 A EA 200500520A EA 200500520 A1 EA200500520 A1 EA 200500520A1
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EA
Eurasian Patent Office
Prior art keywords
ligands
application
cancelinoid
purine compounds
receptor
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Application number
EA200500520A
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English (en)
Other versions
EA008176B1 (ru
Inventor
Дейвид Эндрю Гриффит
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Пфайзер Продактс Инк.
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Publication of EA200500520A1 publication Critical patent/EA200500520A1/ru
Publication of EA008176B1 publication Critical patent/EA008176B1/ru

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Abstract

В описании изобретения раскрыты соединения формулы (I), действующие как лиганды каннабиноидных рецепторов, и их применение в лечении заболеваний, связанных с каннабиноидными рецепторами, у животных.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500520A 2002-10-28 2003-10-21 Пуриновые соединения и их применение в качестве лигандов каннабиноидных рецепторов EA008176B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42187402P 2002-10-28 2002-10-28
PCT/IB2003/004619 WO2004037823A1 (en) 2002-10-28 2003-10-21 Purine compounds and uses thereof as cannabinoid receptor ligands

Publications (2)

Publication Number Publication Date
EA200500520A1 true EA200500520A1 (ru) 2005-12-29
EA008176B1 EA008176B1 (ru) 2007-04-27

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Country Status (45)

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US (2) US7129239B2 (ru)
EP (1) EP1558615B8 (ru)
JP (2) JP3954618B2 (ru)
KR (1) KR100674560B1 (ru)
CN (3) CN100478343C (ru)
AP (1) AP1916A (ru)
AR (1) AR041835A1 (ru)
AT (1) ATE371658T1 (ru)
AU (1) AU2003269368B2 (ru)
BR (1) BR0314918A (ru)
CA (1) CA2503900C (ru)
CO (1) CO5560546A2 (ru)
CR (1) CR7812A (ru)
CU (1) CU23535A3 (ru)
CY (1) CY1107505T1 (ru)
DE (1) DE60316012T2 (ru)
DK (1) DK1558615T3 (ru)
DO (1) DOP2003000742A (ru)
EA (1) EA008176B1 (ru)
EC (1) ECSP055767A (ru)
EG (1) EG24662A (ru)
ES (1) ES2291669T3 (ru)
GE (1) GEP20084325B (ru)
GT (1) GT200300232A (ru)
HK (2) HK1081189A1 (ru)
HR (1) HRP20050378A2 (ru)
IS (1) IS2602B (ru)
MA (1) MA27479A1 (ru)
MX (1) MXPA05003882A (ru)
MY (1) MY140010A (ru)
NL (1) NL1024643C2 (ru)
NO (1) NO332195B1 (ru)
NZ (1) NZ539589A (ru)
OA (1) OA13080A (ru)
PE (1) PE20040781A1 (ru)
PL (1) PL376311A1 (ru)
PT (1) PT1558615E (ru)
RS (2) RS20050306A (ru)
SG (1) SG148071A1 (ru)
TN (1) TNSN05121A1 (ru)
TW (1) TWI327567B (ru)
UA (1) UA79507C2 (ru)
UY (1) UY28044A1 (ru)
WO (1) WO2004037823A1 (ru)
ZA (1) ZA200503378B (ru)

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU