BR0306982A - Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto - Google Patents

Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto

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Publication number
BR0306982A
BR0306982A BR0306982-6A BR0306982A BR0306982A BR 0306982 A BR0306982 A BR 0306982A BR 0306982 A BR0306982 A BR 0306982A BR 0306982 A BR0306982 A BR 0306982A
Authority
BR
Brazil
Prior art keywords
patient
treat
capsaicin receptor
compound
methods
Prior art date
Application number
BR0306982-6A
Other languages
English (en)
Inventor
Rajagopal Bakthavatchalam
Charles A Blum
Harry L Brielmann
Timothy M Caldwell
Stephane De Lombaert
Kevin J Hodgetts
Taeyoung Yoon
Xiaozhang Zheng
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of BR0306982A publication Critical patent/BR0306982A/pt

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

"COMPOSTO OU UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL, COMPOSIçãO FARMACêUTICA, MéTODOS PARA REDUZIR A CONDUTâNCIA DE CáLCIO DE UM RECEPTOR DA CAPSAICINA CELULAR, PARA INIBIR A LIGAçãO DE LIGANDO VANILóIDE A UM RECEPTOR DA CAPSAICINA IN VITRO E EM UM PACIENTE, PARA TRATAR UMA CONDIçãO RESPONSIVA à MODULAçãO DO RECEPTOR DA CAPSAICINA EM UM PACIENTE, PARA TRATAR A DOR EM UM PACIENTE, PARA TRATAR COCEIRA EM UM PACIENTE, PARA TRATAR TOSSE OU SOLUçO EM UM PACIENTE, PROMOVER A PERDA DE PESO EM UM PACIENTE OBESO, E PARA DETERMINAR A PRESENçA OU AUSêNCIA DE RECEPTOR DA CAPSAICINA EM UMA AMOSTRA, PREPARAçãO FARMACêUTICA EMBALADA, E, USO DE UM COMPOSTO". Análogos de quinazolin-4-ilamina substituídos são fornecidos. Tais compostos são ligandos que podem ser usados para modular a atividade de receptor específico in vivo ou in vitro e são particularmente úteis no tratamento de condições associadas com a ativação de receptor patológica em seres humanos, animais de estimação domesticados e animais de criação. As composições farmacêuticas e métodos para usá-los para tratar tais distúrbios são fornecidos, como o são métodos para usar tais ligandos para estudos de localização de receptor.
BR0306982-6A 2002-01-17 2003-01-17 Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto BR0306982A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34992002P 2002-01-17 2002-01-17
US35052702P 2002-01-22 2002-01-22
PCT/US2003/001563 WO2003062209A2 (en) 2002-01-17 2003-01-17 Substituted quinazolin-4-ylamine analogues as modulators of capsaicin

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BR0306982A true BR0306982A (pt) 2004-10-26

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BR0306982-6A BR0306982A (pt) 2002-01-17 2003-01-17 Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto

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US (3) US7074799B2 (pt)
EP (1) EP1471910A2 (pt)
JP (1) JP2005526714A (pt)
KR (1) KR20040085151A (pt)
CN (1) CN1627944A (pt)
BR (1) BR0306982A (pt)
CA (1) CA2473796A1 (pt)
EA (1) EA200400816A1 (pt)
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NO (1) NO20043411L (pt)
PL (1) PL371587A1 (pt)
RS (1) RS63204A (pt)
TW (1) TW200406390A (pt)
WO (1) WO2003062209A2 (pt)

Families Citing this family (100)

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