BR0306982A - Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto - Google Patents
Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um compostoInfo
- Publication number
- BR0306982A BR0306982A BR0306982-6A BR0306982A BR0306982A BR 0306982 A BR0306982 A BR 0306982A BR 0306982 A BR0306982 A BR 0306982A BR 0306982 A BR0306982 A BR 0306982A
- Authority
- BR
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- Prior art keywords
- patient
- treat
- capsaicin receptor
- compound
- methods
- Prior art date
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
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Abstract
"COMPOSTO OU UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL, COMPOSIçãO FARMACêUTICA, MéTODOS PARA REDUZIR A CONDUTâNCIA DE CáLCIO DE UM RECEPTOR DA CAPSAICINA CELULAR, PARA INIBIR A LIGAçãO DE LIGANDO VANILóIDE A UM RECEPTOR DA CAPSAICINA IN VITRO E EM UM PACIENTE, PARA TRATAR UMA CONDIçãO RESPONSIVA à MODULAçãO DO RECEPTOR DA CAPSAICINA EM UM PACIENTE, PARA TRATAR A DOR EM UM PACIENTE, PARA TRATAR COCEIRA EM UM PACIENTE, PARA TRATAR TOSSE OU SOLUçO EM UM PACIENTE, PROMOVER A PERDA DE PESO EM UM PACIENTE OBESO, E PARA DETERMINAR A PRESENçA OU AUSêNCIA DE RECEPTOR DA CAPSAICINA EM UMA AMOSTRA, PREPARAçãO FARMACêUTICA EMBALADA, E, USO DE UM COMPOSTO". Análogos de quinazolin-4-ilamina substituídos são fornecidos. Tais compostos são ligandos que podem ser usados para modular a atividade de receptor específico in vivo ou in vitro e são particularmente úteis no tratamento de condições associadas com a ativação de receptor patológica em seres humanos, animais de estimação domesticados e animais de criação. As composições farmacêuticas e métodos para usá-los para tratar tais distúrbios são fornecidos, como o são métodos para usar tais ligandos para estudos de localização de receptor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34992002P | 2002-01-17 | 2002-01-17 | |
US35052702P | 2002-01-22 | 2002-01-22 | |
PCT/US2003/001563 WO2003062209A2 (en) | 2002-01-17 | 2003-01-17 | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0306982A true BR0306982A (pt) | 2004-10-26 |
Family
ID=27616757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0306982-6A BR0306982A (pt) | 2002-01-17 | 2003-01-17 | Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto |
Country Status (15)
Country | Link |
---|---|
US (3) | US7074799B2 (pt) |
EP (1) | EP1471910A2 (pt) |
JP (1) | JP2005526714A (pt) |
KR (1) | KR20040085151A (pt) |
CN (1) | CN1627944A (pt) |
BR (1) | BR0306982A (pt) |
CA (1) | CA2473796A1 (pt) |
EA (1) | EA200400816A1 (pt) |
HU (1) | HUP0500200A2 (pt) |
MX (1) | MXPA04006882A (pt) |
NO (1) | NO20043411L (pt) |
PL (1) | PL371587A1 (pt) |
RS (1) | RS63204A (pt) |
TW (1) | TW200406390A (pt) |
WO (1) | WO2003062209A2 (pt) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030024799A (ko) * | 2000-07-20 | 2003-03-26 | 뉴로젠 코포레이션 | 캡사이신 수용체 리간드 |
JP4583760B2 (ja) | 2002-02-01 | 2010-11-17 | ユーロ−セルティーク エス.エイ. | 疼痛の治療に有用な治療薬 |
US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
ATE533743T1 (de) | 2002-05-17 | 2011-12-15 | Janssen Pharmaceutica Nv | Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1 |
AU2003299517A1 (en) * | 2002-05-23 | 2004-05-25 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
WO2004002983A2 (en) | 2002-06-28 | 2004-01-08 | Euro-Celtique, S.A. | Therapeutic piperazine derivatives useful for treating pain |
US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
AU2003300791A1 (en) * | 2002-12-13 | 2004-07-09 | Neurogen Corporation | Combination therapy for the treatment of pain |
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- 2003-01-17 MX MXPA04006882A patent/MXPA04006882A/es unknown
- 2003-01-17 EA EA200400816A patent/EA200400816A1/ru unknown
- 2003-01-17 RS YU63204A patent/RS63204A/sr unknown
- 2003-01-17 CA CA002473796A patent/CA2473796A1/en not_active Abandoned
- 2003-01-17 EP EP03703887A patent/EP1471910A2/en not_active Withdrawn
- 2003-01-17 PL PL03371587A patent/PL371587A1/xx not_active Application Discontinuation
- 2003-01-17 HU HU0500200A patent/HUP0500200A2/hu unknown
- 2003-01-17 WO PCT/US2003/001563 patent/WO2003062209A2/en active Application Filing
- 2003-01-21 US US10/347,210 patent/US7074799B2/en not_active Expired - Lifetime
-
2004
- 2004-08-16 NO NO20043411A patent/NO20043411L/no unknown
-
2006
- 2006-02-01 US US11/345,926 patent/US7304059B2/en not_active Expired - Lifetime
-
2007
- 2007-09-29 US US11/864,987 patent/US20080015183A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20060173003A1 (en) | 2006-08-03 |
HUP0500200A2 (hu) | 2005-07-28 |
KR20040085151A (ko) | 2004-10-07 |
MXPA04006882A (es) | 2004-12-06 |
CA2473796A1 (en) | 2003-07-31 |
EP1471910A2 (en) | 2004-11-03 |
US7074799B2 (en) | 2006-07-11 |
CN1627944A (zh) | 2005-06-15 |
US7304059B2 (en) | 2007-12-04 |
TW200406390A (en) | 2004-05-01 |
US20040106616A1 (en) | 2004-06-03 |
NO20043411L (no) | 2004-09-24 |
RS63204A (en) | 2006-10-27 |
WO2003062209A3 (en) | 2003-09-04 |
WO2003062209A2 (en) | 2003-07-31 |
PL371587A1 (en) | 2005-06-27 |
US20080015183A1 (en) | 2008-01-17 |
JP2005526714A (ja) | 2005-09-08 |
EA200400816A1 (ru) | 2005-02-24 |
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