WO2007140383A3 - Spirocyclic sulfonamides and related compounds - Google Patents

Spirocyclic sulfonamides and related compounds Download PDF

Info

Publication number
WO2007140383A3
WO2007140383A3 PCT/US2007/069918 US2007069918W WO2007140383A3 WO 2007140383 A3 WO2007140383 A3 WO 2007140383A3 US 2007069918 W US2007069918 W US 2007069918W WO 2007140383 A3 WO2007140383 A3 WO 2007140383A3
Authority
WO
WIPO (PCT)
Prior art keywords
spirocyclic
sulfonamides
related compounds
formula
methods
Prior art date
Application number
PCT/US2007/069918
Other languages
French (fr)
Other versions
WO2007140383A2 (en
Inventor
Kevin J Hodgetts
David C Ihle
Guiying Li
Ping Ge
Bertrand L Chenard
David J Wustrow
Original Assignee
Neurogen Corp
Kevin J Hodgetts
David C Ihle
Guiying Li
Ping Ge
Bertrand L Chenard
David J Wustrow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Kevin J Hodgetts, David C Ihle, Guiying Li, Ping Ge, Bertrand L Chenard, David J Wustrow filed Critical Neurogen Corp
Publication of WO2007140383A2 publication Critical patent/WO2007140383A2/en
Publication of WO2007140383A3 publication Critical patent/WO2007140383A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Abstract

Spirocyclic sulfonamides and related compounds of Formula 1 are provided : (Formula (I)): in which the variables are as described herein. Such compounds may be used to modulate bradykinin receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to Bi modulation in humans, domesticated companion animals and livestock animals, including inflammation and pain. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies and various in vitro assays.
PCT/US2007/069918 2006-05-30 2007-05-30 Spirocyclic sulfonamides and related compounds WO2007140383A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80341906P 2006-05-30 2006-05-30
US60/803,419 2006-05-30

Publications (2)

Publication Number Publication Date
WO2007140383A2 WO2007140383A2 (en) 2007-12-06
WO2007140383A3 true WO2007140383A3 (en) 2008-01-24

Family

ID=38779418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069918 WO2007140383A2 (en) 2006-05-30 2007-05-30 Spirocyclic sulfonamides and related compounds

Country Status (1)

Country Link
WO (1) WO2007140383A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007034620A1 (en) * 2007-07-25 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New B1 antagonists
EP2262792A1 (en) 2008-04-08 2010-12-22 Grünenthal GmbH Substituted sulfonamide derivatives
JP2011516514A (en) * 2008-04-08 2011-05-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Substituted sulfonamide derivatives
TW200944530A (en) 2008-04-09 2009-11-01 Gruenenthal Chemie Substituted sulfonamide derivatives
TW201022267A (en) 2008-10-23 2010-06-16 Gruenenthal Gmbh Substituierte pyrimidin-und triazin-derivate
AU2009309988A1 (en) 2008-10-29 2010-05-06 Grunenthal Gmbh Substituted spiroamines
TW201020247A (en) 2008-11-06 2010-06-01 Gruenenthal Gmbh Substituierte disulfonamide
TW201031665A (en) 2009-02-04 2010-09-01 Gruenenthal Gmbh Substituted indole-compound
TW201030007A (en) 2009-02-06 2010-08-16 Gruenenthal Gmbh Substituted spiro-amides as b1r modulators
TW201035102A (en) 2009-03-04 2010-10-01 Gruenethal Gmbh Sulfonylated tetrahydroazolopyrazines and their use as medicinal products
TW201038572A (en) 2009-03-25 2010-11-01 Gruenenthal Gmbh Substituted spiro-amide compounds
WO2010142402A1 (en) 2009-06-08 2010-12-16 Grünenthal GmbH Substituted benzimidazoles, benzothiazoles and benzoxazoles
WO2012028331A1 (en) 2010-09-03 2012-03-08 Grünenthal GmbH Substituted tetrahydropyrrolopyrazine derivatives
TW201217312A (en) 2010-09-22 2012-05-01 Gruenenthal Gmbh Substituted benzamide compounds
CN107216335B (en) * 2017-06-29 2019-04-30 上海药明康德新药开发有限公司 A kind of tert-butyl 1- (methylol) -3- oxa- -9- azaspiro [5.5] hendecane -9- formic acid base ester preparation method
WO2020048828A1 (en) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds
AR116020A1 (en) 2018-09-03 2021-03-25 Bayer Ag 3,9-DIAZAESPIRO [5.5] UNDECANO COMPOUNDS AS GGTase I INHIBITORS AND THEIR USE FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113140A2 (en) * 2005-04-15 2006-10-26 Elan Pharmaceuticals, Inc. Novel compounds useful for bradykinin b1 receptor antagonism

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113140A2 (en) * 2005-04-15 2006-10-26 Elan Pharmaceuticals, Inc. Novel compounds useful for bradykinin b1 receptor antagonism

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAS [online] accession no. STN Database accession no. (2006:1124909) *

Also Published As

Publication number Publication date
WO2007140383A2 (en) 2007-12-06

Similar Documents

Publication Publication Date Title
WO2007140383A3 (en) Spirocyclic sulfonamides and related compounds
WO2007101007A8 (en) Aryl sulfonyl heterocycles
WO2006078992A3 (en) Heteroaryl substituted piperazinyl-pyridine analogues
WO2006026135A3 (en) Substituted biaryl piperazinyl-pyridine analogues
WO2008066789A3 (en) Heteroaryl amide derivatives
WO2009012482A3 (en) 5-membered heterocyclic amides and related compounds
WO2006076646A3 (en) Heteroaryl substituted quinolin-4-ylamine analogues
MY148461A (en) Heteroaryl amide analogues as p2x7 antagonists
TW200716594A (en) Substituted heteroaryl CB1 antagonists
WO2005007648A3 (en) Biaryl piperazinyl-pyridine analogues
WO2004055004A8 (en) Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
WO2006081388A3 (en) Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues
WO2006049941A3 (en) Diaryl ureas as cb1 antagonists
WO2005007652A3 (en) Substituted quinolin-4-ylamine analogues
WO2006042289A3 (en) Substituted biaryl quinolin-4-ylamine analogues
WO2008033739A3 (en) Benzimidazole carboxamide derivatives
WO2008024433A3 (en) Haloalkyl-substituted pyrimidinone derivatives
WO2005084401A3 (en) Aryl substituted purine analogues
WO2008024438A3 (en) 2-phenoxy pyrimidinone analogues
WO2007146761A3 (en) Diaryl pyrimidinones and related compounds
WO2005023807A3 (en) 4 - heterobicyclyamino - substituted quinazolines and analogues therof as capsaicin - antagonists
WO2008066664A3 (en) Cis-cyclohexyl substituted pyrimidinone derivatives
WO2005084368A3 (en) Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogues
WO2006071538A3 (en) Substituted biaryl analogues
WO2008070014A3 (en) Biaryl ketone-substituted piperidines

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07797861

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07797861

Country of ref document: EP

Kind code of ref document: A2