WO2008070014A3 - Biaryl ketone-substituted piperidines - Google Patents

Biaryl ketone-substituted piperidines Download PDF

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Publication number
WO2008070014A3
WO2008070014A3 PCT/US2007/024717 US2007024717W WO2008070014A3 WO 2008070014 A3 WO2008070014 A3 WO 2008070014A3 US 2007024717 W US2007024717 W US 2007024717W WO 2008070014 A3 WO2008070014 A3 WO 2008070014A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted piperidines
cgrp
compounds
methods
biaryl ketone
Prior art date
Application number
PCT/US2007/024717
Other languages
French (fr)
Other versions
WO2008070014A2 (en
Inventor
Rajagopal Bakthavatchalm
Bertrand L Chenard
Scott M Capitosti
Alan J Hutchison
Robert Ohliger
John M Peterson
Original Assignee
Neurogen Corp
Rajagopal Bakthavatchalm
Bertrand L Chenard
Scott M Capitosti
Alan J Hutchison
Robert Ohliger
John M Peterson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Rajagopal Bakthavatchalm, Bertrand L Chenard, Scott M Capitosti, Alan J Hutchison, Robert Ohliger, John M Peterson filed Critical Neurogen Corp
Publication of WO2008070014A2 publication Critical patent/WO2008070014A2/en
Publication of WO2008070014A3 publication Critical patent/WO2008070014A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Biaryl ketone-substituted piperidines of the following Formulas are provided:, and in which the variables are as described herein. Such compounds may be used to modulate calcitonin gene-related peptide (CGRP) receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CGRP modulation in humans, domesticated companion animals and livestock animals, including headache such as migraine. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such compounds for receptor localization studies and various in vitro assays.
PCT/US2007/024717 2006-12-04 2007-11-28 Biaryl ketone-substituted piperidines WO2008070014A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86836606P 2006-12-04 2006-12-04
US60/868,366 2006-12-04
US88717107P 2007-01-30 2007-01-30
US60/887,171 2007-01-30

Publications (2)

Publication Number Publication Date
WO2008070014A2 WO2008070014A2 (en) 2008-06-12
WO2008070014A3 true WO2008070014A3 (en) 2009-04-02

Family

ID=39492822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024717 WO2008070014A2 (en) 2006-12-04 2007-11-28 Biaryl ketone-substituted piperidines

Country Status (1)

Country Link
WO (1) WO2008070014A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008313733A1 (en) 2007-10-18 2009-04-23 Boehringer Ingelheim International Gmbh CGRP antagonists
EP2065381A1 (en) * 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP antagonists
CA2705405A1 (en) 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh New compounds
AU2014201037B9 (en) * 2010-04-06 2015-11-19 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and method for producing same
JP5499160B2 (en) 2010-04-06 2014-05-21 日本曹達株式会社 Nitrogen-containing heterocyclic compound and method for producing the same
EP2569299A1 (en) * 2010-05-13 2013-03-20 Amgen Inc. Nitrogen- heterocyclic compounds as phosphodiesterase 10 inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268474B1 (en) * 1998-04-30 2001-07-31 Creighton University Peptide antagonists of CGRP-receptor superfamily and methods of use
WO2001066248A2 (en) * 2000-02-22 2001-09-13 University Of New Orleans Research And Technology Foundation C-c and c-n coupling catalyst comprising transition metal and carbene
WO2004091514A2 (en) * 2003-04-15 2004-10-28 Merck & Co., Inc. Cgrp receptor antagonists
WO2006052378A1 (en) * 2004-11-03 2006-05-18 Bristol-Myers Squibb Company Constrained compounds as cgrp-receptor antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268474B1 (en) * 1998-04-30 2001-07-31 Creighton University Peptide antagonists of CGRP-receptor superfamily and methods of use
WO2001066248A2 (en) * 2000-02-22 2001-09-13 University Of New Orleans Research And Technology Foundation C-c and c-n coupling catalyst comprising transition metal and carbene
WO2004091514A2 (en) * 2003-04-15 2004-10-28 Merck & Co., Inc. Cgrp receptor antagonists
WO2006052378A1 (en) * 2004-11-03 2006-05-18 Bristol-Myers Squibb Company Constrained compounds as cgrp-receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CONNER ET AL.: "The Second Intracellular Loop of the Calcitonin Gene-related Peptide Receptor Provides Molecular Determinants for Signal Transduction and Cell Surface Expression.", J. BIOL. CHEM., vol. 281, no. 3, 20 January 2006 (2006-01-20), pages 1644 - 1651, XP008109007, DOI: doi:10.1074/jbc.M510064200 *

Also Published As

Publication number Publication date
WO2008070014A2 (en) 2008-06-12

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