BR0214610A - Composições poliméricas de liberação controlada de compostos promotores do crescimento ósseo - Google Patents

Composições poliméricas de liberação controlada de compostos promotores do crescimento ósseo

Info

Publication number
BR0214610A
BR0214610A BR0214610-0A BR0214610A BR0214610A BR 0214610 A BR0214610 A BR 0214610A BR 0214610 A BR0214610 A BR 0214610A BR 0214610 A BR0214610 A BR 0214610A
Authority
BR
Brazil
Prior art keywords
growth promoting
bone growth
controlled release
polymeric compositions
promoting compounds
Prior art date
Application number
BR0214610-0A
Other languages
English (en)
Inventor
Francis Dumont
Richard Wilker Korsmeyer
Mei Li
Vishwas Madhav Paralkar
Richard Lee Dunn
Scott Alexander Jeffers
Mingxing Zhou
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0214610A publication Critical patent/BR0214610A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSIçõES POLIMéRICAS DE LIBERAçãO CONTROLADA DE COMPOSTOS PROMOTORES DO CRESCIMENTO óSSEO". A presente invenção refere-se a um sistema aperfeiçoado para a liberação controlada de um composto promotor do crescimento ósseo e a uma composição escoável para a sua formação. A composição escoável é composta por um polímero termoplástico, um composto promotor de crescimento ósseo e um solvente orgânico. A composição escoável é capaz de formar uma matriz polimérica sólida, microporosa biodegradável e/ou que possa ser biocorroída. A matriz é útil como um implante em pacientes (humanos e animais) para administração de um composto promotor do crescimento ósseo de tecidos ósseos.
BR0214610-0A 2001-11-30 2002-11-20 Composições poliméricas de liberação controlada de compostos promotores do crescimento ósseo BR0214610A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33725501P 2001-11-30 2001-11-30
PCT/IB2002/004965 WO2003045351A1 (en) 2001-11-30 2002-11-20 Controlled release polymeric compositions of bone growth promoting compounds

Publications (1)

Publication Number Publication Date
BR0214610A true BR0214610A (pt) 2004-09-14

Family

ID=23319774

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214610-0A BR0214610A (pt) 2001-11-30 2002-11-20 Composições poliméricas de liberação controlada de compostos promotores do crescimento ósseo

Country Status (34)

Country Link
US (2) US20030104031A1 (pt)
EP (1) EP1448166A1 (pt)
JP (1) JP4903985B2 (pt)
KR (1) KR100629380B1 (pt)
CN (1) CN1599598A (pt)
AP (1) AP1781A (pt)
AR (1) AR037462A1 (pt)
AU (2) AU2002347502A1 (pt)
BR (1) BR0214610A (pt)
CA (1) CA2468703C (pt)
DO (1) DOP2002000534A (pt)
EA (1) EA011350B1 (pt)
EC (1) ECSP045124A (pt)
GE (1) GEP20063951B (pt)
GT (1) GT200200242A (pt)
HR (1) HRP20040486A2 (pt)
HU (1) HUP0402135A3 (pt)
IL (1) IL161835A0 (pt)
IS (1) IS7217A (pt)
MA (1) MA27084A1 (pt)
MX (1) MXPA04003723A (pt)
NO (1) NO20042273L (pt)
NZ (1) NZ533115A (pt)
OA (1) OA12731A (pt)
PA (1) PA8559001A1 (pt)
PE (1) PE20030581A1 (pt)
PL (1) PL370085A1 (pt)
SV (1) SV2004001421A (pt)
TN (1) TNSN04096A1 (pt)
TW (1) TW200300695A (pt)
UA (1) UA76792C2 (pt)
WO (1) WO2003045351A1 (pt)
YU (1) YU35004A (pt)
ZA (1) ZA200402755B (pt)

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WO2004071356A2 (en) * 2003-02-10 2004-08-26 Smith & Nephew, Inc. Resorbable devices
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
CA2540586A1 (en) * 2003-10-01 2005-04-21 Optimer Pharmaceuticals, Inc. Treatment of a condition in a mammal with administration of aminosugar and uses thereof
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US8641738B1 (en) 2004-10-28 2014-02-04 James W. Ogilvie Method of treating scoliosis using a biological implant
US8123787B2 (en) 2004-10-28 2012-02-28 Ogilvie James W Method of treating scoliosis using a biological implant
EP1922091A2 (en) * 2005-08-18 2008-05-21 Smith & Nephew, PLC High strength devices and composites
CN100443065C (zh) * 2006-01-26 2008-12-17 上海交通大学 用于颌面骨缺损修复的复合体系植入体单元
DE602007011671D1 (de) 2006-11-30 2011-02-10 Smith & Nephew Inc Faserverstärktes verbundmaterial
EP2142353A1 (en) 2007-04-18 2010-01-13 Smith & Nephew PLC Expansion moulding of shape memory polymers
JP5680957B2 (ja) 2007-04-19 2015-03-04 スミス アンド ネフュー インコーポレーテッドＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ，Ｉｎｃ． グラフト固定
JP5520814B2 (ja) 2007-04-19 2014-06-11 スミス アンド ネフュー インコーポレーテッド マルチモーダル形状記憶ポリマー
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
EP2172189A1 (en) * 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
PT2323623T (pt) 2008-08-12 2016-11-04 Novartis Ag Composições farmacêuticas
WO2010045487A1 (en) * 2008-10-15 2010-04-22 Palmetto Biomedical, Inc. Device and method for delivery of therapeutic agents via internal implants
US9642658B2 (en) 2008-10-15 2017-05-09 Orthoclip Llc Device and method for delivery of therapeutic agents via internal implants
CN102470184B (zh) 2009-08-06 2017-05-31 皇家飞利浦电子股份有限公司 采用放射性种子的肿瘤治疗
AU2013201121A1 (en) 2011-09-20 2013-04-04 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
CN104189954B (zh) * 2014-09-19 2017-03-29 中国科学院长春应用化学研究所 一种原位固化组织工程支架及其制备方法
RU2571548C1 (ru) * 2014-12-17 2015-12-20 Федеральное государственное бюджетное учреждение науки Институт органической и физической химии им. А.Е. Арбузова Казанского научного центра Российской академии наук Ветеринарное имплантируемое средство пролонгированного действия (варианты)
JP6835841B2 (ja) 2015-11-16 2021-02-24 エボニック オペレーションズ ゲーエムベーハー 非核酸系逆転写酵素阻害剤とポリ（ラクチド−ｃｏ−グリコリド）とを含む注射液
CN109498852B (zh) * 2018-12-29 2022-06-24 广州噢斯荣医药技术有限公司 治疗骨科疾病的生物降解材料及其应用
US20220409642A1 (en) 2019-11-04 2022-12-29 Astrazeneca Ab Combination therapy for treating cancer
JP2024501783A (ja) 2020-12-29 2024-01-15 シノ メディカル サイエンシズ テクノロジー インコーポレイテッド 薬剤溶出ステント
WO2024089418A1 (en) 2022-10-24 2024-05-02 Cancer Research Technology Limited Tumour sensitisation to checkpoint inhibitors with redox status modifier
WO2024089417A1 (en) 2022-10-24 2024-05-02 Memorial Sloan-Kettering Cancer Center Tumour stratification for responsiveness to an immune checkpoint inhibitor

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Also Published As

Publication number Publication date
NO20042273L (no) 2004-07-14
SV2004001421A (es) 2004-05-07
EA200400608A1 (ru) 2004-10-28
KR20040062977A (ko) 2004-07-09
OA12731A (en) 2006-06-28
CN1599598A (zh) 2005-03-23
ECSP045124A (es) 2004-07-23
EP1448166A1 (en) 2004-08-25
AU2002347502A1 (en) 2003-06-10
WO2003045351A1 (en) 2003-06-05
JP2005515190A (ja) 2005-05-26
PE20030581A1 (es) 2003-07-08
IL161835A0 (en) 2005-11-20
NZ533115A (en) 2005-12-23
MXPA04003723A (es) 2005-04-08
JP4903985B2 (ja) 2012-03-28
PL370085A1 (en) 2005-05-16
CA2468703A1 (en) 2003-06-05
YU35004A (sh) 2006-08-17
AU2009200125B2 (en) 2012-02-02
KR100629380B1 (ko) 2006-09-29
AU2009200125A1 (en) 2009-02-05
ZA200402755B (en) 2005-04-08
MA27084A1 (fr) 2004-12-20
TW200300695A (en) 2003-06-16
EA011350B1 (ru) 2009-02-27
AP1781A (en) 2007-09-27
HUP0402135A3 (en) 2008-04-28
AR037462A1 (es) 2004-11-10
CA2468703C (en) 2009-12-29
US20090169595A1 (en) 2009-07-02
PA8559001A1 (es) 2003-11-12
HUP0402135A2 (hu) 2005-02-28
HRP20040486A2 (en) 2004-10-31
TNSN04096A1 (fr) 2006-06-01
GT200200242A (es) 2003-06-25
DOP2002000534A (es) 2003-05-31
IS7217A (is) 2004-04-07
US8017144B2 (en) 2011-09-13
GEP20063951B (en) 2006-10-25
US20030104031A1 (en) 2003-06-05
AP2004003037A0 (en) 2004-06-30
UA76792C2 (uk) 2006-09-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.