CO5460266A1 - Novedosos analogos de la somatostatina - Google Patents
Novedosos analogos de la somatostatinaInfo
- Publication number
- CO5460266A1 CO5460266A1 CO00063458A CO00063458A CO5460266A1 CO 5460266 A1 CO5460266 A1 CO 5460266A1 CO 00063458 A CO00063458 A CO 00063458A CO 00063458 A CO00063458 A CO 00063458A CO 5460266 A1 CO5460266 A1 CO 5460266A1
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- somatostatin
- analogs
- somatostatine
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La invención provee novedosos farmacóforos basados en péptidos y compuestos que se enlazan con gran afinidad a los receptores de la somatostatina y que presentan propiedades farmacocinéticas mejoradas frente a los análogos de somatostatina conocidos. Los farmacóforos y compuestos de la invención pueden ser utilizados en forma marcada o no marcada para diagnosticar y/o tratar enfermedades de responsabilidad de la somatostatina. La invención también provee radiofármacos y equipos que comprenden estos compuestos, como también métodos para diagnosticar y/o tratar enfermedades mediadas por los receptores de la somatostatina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15100199P | 1999-08-27 | 1999-08-27 | |
US09/397,792 US6358491B1 (en) | 1999-08-27 | 1999-09-16 | Somatostatin analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5460266A1 true CO5460266A1 (es) | 2004-11-30 |
Family
ID=26848228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00063458A CO5460266A1 (es) | 1999-08-27 | 2000-08-24 | Novedosos analogos de la somatostatina |
Country Status (12)
Country | Link |
---|---|
US (1) | US6358491B1 (es) |
EP (1) | EP1208116B1 (es) |
JP (1) | JP2003517037A (es) |
AT (1) | ATE393781T1 (es) |
AU (1) | AU782873B2 (es) |
CA (1) | CA2383936A1 (es) |
CO (1) | CO5460266A1 (es) |
DE (1) | DE60038739T2 (es) |
ES (1) | ES2305000T3 (es) |
PE (1) | PE20010516A1 (es) |
TW (1) | TWI243178B (es) |
WO (1) | WO2001044177A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE395002T1 (de) * | 1997-11-24 | 2008-05-15 | Univ Louisiana State | Verfahren zum verbessern der anhäufung von radioaktiven verbindungen in gewebe |
EP1283216A1 (en) * | 2001-08-10 | 2003-02-12 | Mallinckrodt Inc. | Somatostatin analogues binding to all somatostatin receptor subtypes and their use |
DE10215336A1 (de) | 2002-03-28 | 2003-10-23 | Schering Ag | N-Methyl-Homocysteine und ihre Verwendung sowie Verfahren zu ihrer Herstellung |
WO2003057214A1 (en) * | 2001-12-28 | 2003-07-17 | Somatocor Pharmaceuticals, Inc. | Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands |
JP5395327B2 (ja) | 2003-09-17 | 2014-01-22 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 機構ベースの標的化した膵臓β細胞画像化および治療 |
EP1700608A1 (en) | 2005-03-10 | 2006-09-13 | Schering AG | Chelators for radioactively labeled conjugates comprising a stabilizing sidechain |
JP2008538204A (ja) * | 2005-03-10 | 2008-10-16 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 安定化側鎖を含む放射性標識複合体キレート剤 |
EP1717247A1 (en) * | 2005-04-28 | 2006-11-02 | Schering AG | Cyclic peptides binding to the somatostatin receptor |
WO2006114324A1 (en) * | 2005-04-28 | 2006-11-02 | Schering Ag | Compounds comprising cyclized somatostatin receptor binding peptides |
EP1717219A1 (en) * | 2005-04-28 | 2006-11-02 | Schering AG | Orthogonally protected bifunctional amino acid |
US20070025910A1 (en) | 2005-07-29 | 2007-02-01 | Norenberg Jeffrey P | Anticancer therapy |
ES2351569B8 (es) * | 2009-05-07 | 2012-06-20 | Bcn Peptides S.A. | Ligandos peptídicos de receptores de somatostatina. |
RU2528414C1 (ru) * | 2013-01-25 | 2014-09-20 | Закрытое Акционерное Общество "Фарм-Синтез" | Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы |
US20160031935A1 (en) * | 2013-03-15 | 2016-02-04 | Adaerata, Limited Partnership | Small molecule modulators of pcsk9 and methods of use thereof |
KR102062025B1 (ko) | 2014-06-30 | 2020-01-03 | 타베다 세라퓨틱스, 인코포레이티드 | 표적화된 콘주게이트 및 입자 및 그것의 제형 |
AU2016343817B2 (en) | 2015-10-28 | 2021-05-27 | Tva (Abc), Llc | SSTR-targeted conjugates and particles and formulations thereof |
DK3568205T3 (da) | 2017-01-12 | 2023-10-09 | Radiomedix Inc | Behandling af cancerceller, der overeksprimerer somatostatinreceptorer ved at anvende radioisotop-chelaterede ocreotid-derivater |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4310518A (en) | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4486415A (en) | 1983-08-15 | 1984-12-04 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4522813A (en) | 1983-10-27 | 1985-06-11 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
EP0222578A3 (en) | 1985-11-06 | 1990-04-04 | Merck & Co. Inc. | Use of cyclic somatostatin analogues in the treatment of immediate hypersensitivity diseases |
US5776894A (en) | 1988-12-05 | 1998-07-07 | Novartis Ag | Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors |
US5985240A (en) | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5932189A (en) * | 1994-07-29 | 1999-08-03 | Diatech, Inc. | Cyclic peptide somatostatin analogs |
ES2158897T3 (es) * | 1993-06-23 | 2001-09-16 | Diatide Inc | Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos. |
GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
US5597894A (en) | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
US5770687A (en) | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
US5830431A (en) | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
MY147327A (en) | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
US5708135A (en) | 1995-09-29 | 1998-01-13 | Biomeasure Incorporated | Cyclic peptide analogs of somatostatin |
AT405906B (de) | 1997-03-14 | 1999-12-27 | Irene Dr Virgolini | Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie |
-
1999
- 1999-09-16 US US09/397,792 patent/US6358491B1/en not_active Expired - Lifetime
-
2000
- 2000-08-18 TW TW089116770A patent/TWI243178B/zh not_active IP Right Cessation
- 2000-08-22 PE PE2000000852A patent/PE20010516A1/es not_active Application Discontinuation
- 2000-08-23 ES ES00992965T patent/ES2305000T3/es not_active Expired - Lifetime
- 2000-08-23 AU AU48659/01A patent/AU782873B2/en not_active Ceased
- 2000-08-23 WO PCT/IB2000/002072 patent/WO2001044177A2/en active IP Right Grant
- 2000-08-23 JP JP2001545265A patent/JP2003517037A/ja active Pending
- 2000-08-23 DE DE60038739T patent/DE60038739T2/de not_active Expired - Lifetime
- 2000-08-23 EP EP00992965A patent/EP1208116B1/en not_active Expired - Lifetime
- 2000-08-23 CA CA002383936A patent/CA2383936A1/en not_active Abandoned
- 2000-08-23 AT AT00992965T patent/ATE393781T1/de not_active IP Right Cessation
- 2000-08-24 CO CO00063458A patent/CO5460266A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE393781T1 (de) | 2008-05-15 |
CA2383936A1 (en) | 2001-06-21 |
US6358491B1 (en) | 2002-03-19 |
WO2001044177A3 (en) | 2002-03-28 |
AU782873B2 (en) | 2005-09-08 |
EP1208116B1 (en) | 2008-04-30 |
WO2001044177A2 (en) | 2001-06-21 |
JP2003517037A (ja) | 2003-05-20 |
PE20010516A1 (es) | 2001-04-29 |
TWI243178B (en) | 2005-11-11 |
DE60038739D1 (de) | 2008-06-12 |
AU4865901A (en) | 2001-06-25 |
EP1208116A2 (en) | 2002-05-29 |
ES2305000T3 (es) | 2008-11-01 |
DE60038739T2 (de) | 2009-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |