ES2158897T3 - Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos. - Google Patents

Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.

Info

Publication number
ES2158897T3
ES2158897T3 ES94920076T ES94920076T ES2158897T3 ES 2158897 T3 ES2158897 T3 ES 2158897T3 ES 94920076 T ES94920076 T ES 94920076T ES 94920076 T ES94920076 T ES 94920076T ES 2158897 T3 ES2158897 T3 ES 2158897T3
Authority
ES
Spain
Prior art keywords
peptides
sup
somatostatin
radiolabeled
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94920076T
Other languages
English (en)
Inventor
Richard T Dean
William Mcbride
John Lister-James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diatide Inc
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/006029 external-priority patent/WO1994000489A2/en
Priority claimed from US08/092,355 external-priority patent/US6017509A/en
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of ES2158897T3 publication Critical patent/ES2158897T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ESTA INVENCION SE REFIERE A REACTIVOS Y PEPTIDOS TERAPEUTICOS, INCLUIDOS LOS REACTIVOS Y PEPTIDOS RADIOTERAPEUTICOS, REACTIVOS Y PEPTIDOS DE RADIODIAGNOSTICO, Y A METODOS PARA LA PRODUCCION DE AGENTES DE RADIODIAGNOSTICO MARCADOS. ESPECIFICAMENTE, LA INVENCION SE REFIERE A DERIVADOS DE PEPTIDOS CICLICOS Y A ANALOGOS DE LA SOMATOSTATINA, Y A ASPECTOS DE TALES PEPTIDOS RADIOMARCADORES CON UN RADIOISOTOPO, ASI COMO A METODOS Y KITS PARA LA PRODUCCION, RADIOEMARCADO Y USO DE TALES PEPTIDOS CON FINES DE RADIODIAGNOSTICO Y RADIOTERAPEUTICOS. LA INVENCION SE REFIERE ESPECIFICAMENTE A DERIVADOS DE PEPTIDOS CICLICOS Y A ANALOGOS DE LA SOMATOSTATINA RADIOMARCADOS CON TECNECIO-99M Y A LOS USOS DE LOS MISMOS COMO AGENTES DE FORMACION DE IMAGENES ESCINTIGRAFICAS. LA INVENCION TAMBIEN SE REFIERE ESPECIFICAMENTE A DERIVADOS DE PEPTIDOS CICLICOS Y A ANALOGOS DE LA SOMATOSTATINA RADIOMARCADOS CON RADIOISOTOPOS CITOTOXICOS TALES COMO RENIO-186 ({SUP,186}RE) Y RENIO-188 ({SUP,188}RE) PARA SU USO COMO AGENTESRADIOTERAPEUTICOS. TAMBIEN SE PRESENTAN METODOS Y KITS PARA LA PRODUCCION, RADIOMARCADO Y UTILIZACION DE TALES PEPTIDOS CON FINES DE DIAGNOSTICO Y TERAPEUTICOS EN UN MAMIFERO.
ES94920076T 1993-06-23 1994-06-03 Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos. Expired - Lifetime ES2158897T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1993/006029 WO1994000489A2 (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
US08/092,355 US6017509A (en) 1991-11-27 1993-07-15 Radiolabeled somatostatin receptor-binding peptides

Publications (1)

Publication Number Publication Date
ES2158897T3 true ES2158897T3 (es) 2001-09-16

Family

ID=22232834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94920076T Expired - Lifetime ES2158897T3 (es) 1993-06-23 1994-06-03 Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.

Country Status (11)

Country Link
US (1) US6214316B1 (es)
EP (3) EP1099707A3 (es)
AT (2) ATE337338T1 (es)
AU (1) AU701083B2 (es)
CA (1) CA2167281C (es)
DE (2) DE69426673T2 (es)
DK (1) DK0720621T3 (es)
ES (1) ES2158897T3 (es)
GR (1) GR3035830T3 (es)
SG (3) SG90060A1 (es)
WO (1) WO1995000553A1 (es)

Families Citing this family (33)

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US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
PT772459E (pt) * 1994-05-02 2003-06-30 Diatide Inc Agentes de imagem marcados tecnecio-99m
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
GB0105224D0 (en) 2001-03-02 2001-04-18 Nycomed Amersham Plc Improved peptide-chelate conjugates
US20020187099A1 (en) * 2001-05-16 2002-12-12 Rajesh Manchanda Stabilization of radionuclide-containing compositions
AR044852A1 (es) 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
GB0318682D0 (en) * 2003-08-08 2003-09-10 Novartis Ag Organic compounds
ITMI20040812A1 (it) * 2004-04-26 2004-07-26 Chemi Spa Processo per la formazione di legami disofluro in peptidi ciclici
WO2006114324A1 (en) * 2005-04-28 2006-11-02 Schering Ag Compounds comprising cyclized somatostatin receptor binding peptides
EP1717247A1 (en) * 2005-04-28 2006-11-02 Schering AG Cyclic peptides binding to the somatostatin receptor
RU2015120570A (ru) 2012-11-01 2016-12-20 Ипсен Фарма С.А.С. Аналоги соматостатина и их димеры
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
US9480759B2 (en) 2012-11-21 2016-11-01 Serene, Llc Tin-117m somatostatin receptor binding compounds and methods
CN110256310A (zh) * 2019-07-01 2019-09-20 吉尔生化（上海）有限公司 一种n-芴甲氧羰基-s-(4-甲氧基三苯甲基)-l-高半胱氨酸的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1083143A (en) * 1976-01-02 1980-08-05 Nedumparambil A. Abraham Carba derivatives of somatostatin and process therefor
CA1126664A (en) 1979-03-06 1982-06-29 Michael G. Webb Anti-pollution equipment
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4486415A (en) 1983-08-15 1984-12-04 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4725577A (en) 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4585755A (en) * 1985-04-29 1986-04-29 Merck & Co., Inc. Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
US4611054A (en) * 1985-04-29 1986-09-09 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
DE3684410D1 (de) 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
EP0255224A3 (en) * 1986-06-30 1990-04-18 Merck & Co. Inc. Cyclic and bridged cyclic somatostatin analogs useful as analgesic agents
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IL97459A0 (en) * 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
KR930703024A (ko) * 1991-02-08 1993-11-29 리챠드 티. 딘 영상용 테크네튬-99m표지폴리펩티드
EP0597997B1 (en) * 1991-08-09 1998-05-20 KOLBECK, Winfried Lanthionine bridged peptides
CA2127284C (en) * 1992-01-03 2002-02-05 Buck A. Rhodes Protein- and peptide-metal ion pharmaceutical applications
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses

Also Published As

Publication number Publication date
US6214316B1 (en) 2001-04-10
SG93839A1 (en) 2003-01-21
DE69434832D1 (de) 2006-10-05
EP1092726A3 (en) 2002-01-09
WO1995000553A1 (en) 1995-01-05
EP0720621A1 (en) 1996-07-10
DE69426673T2 (de) 2001-09-20
DK0720621T3 (da) 2001-08-06
GR3035830T3 (en) 2001-08-31
DE69426673D1 (de) 2001-03-15
ATE199089T1 (de) 2001-02-15
SG90060A1 (en) 2002-07-23
CA2167281C (en) 2001-09-04
ATE337338T1 (de) 2006-09-15
AU701083B2 (en) 1999-01-21
EP1099707A3 (en) 2002-01-09
EP1099707A2 (en) 2001-05-16
EP0720621B1 (en) 2001-02-07
CA2167281A1 (en) 1995-01-05
EP1092726B1 (en) 2006-08-23
SG48977A1 (en) 1998-05-18
EP1092726A2 (en) 2001-04-18
AU7099094A (en) 1995-01-17

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