MY106120A - Peptide derivatives. - Google Patents

Peptide derivatives.

Info

Publication number
MY106120A
MY106120A MYPI89001655A MYPI19891655A MY106120A MY 106120 A MY106120 A MY 106120A MY PI89001655 A MYPI89001655 A MY PI89001655A MY PI19891655 A MYPI19891655 A MY PI19891655A MY 106120 A MY106120 A MY 106120A
Authority
MY
Malaysia
Prior art keywords
somatostatin
peptide derivatives
detectable element
amino group
group
Prior art date
Application number
MYPI89001655A
Inventor
Dr Steven W J Lamberts Prof
Janos Pless dr
Eric P Krenning Dr
Rainer Albert Dr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MY106120A publication Critical patent/MY106120A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SOMATOSTATIN PEPTIDES BEARING AT LEAST ONE CHELATING GROUP FOR A DETECTABLE ELEMENT, SAID CHELATING GROUP BEING LINKED TO AN AMINO GROUP OF SAID PEPTIDE, AND SAID AMINO GROUP HAVING NO SIGNIFICANT BINDING AFFINITY FOR SOMATOSTATIN RECEPTORS, IN FREE OR SALT FORM, ARE COMPLEXED WITH A DETECTABLE ELEMENT AND AS SUCH ARE USEFUL AS A PHARMACEUTICAL, E.G. A RADIOPHARMACEUTICAL FOR IN VIVO IMAGING OF SOMATOSTATIN RECEPTOR POSITIVE TUMORS OR FOR THERAPY.
MYPI89001655A 1988-12-05 1989-11-29 Peptide derivatives. MY106120A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
MY106120A true MY106120A (en) 1995-03-31

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI89001655A MY106120A (en) 1988-12-05 1989-11-29 Peptide derivatives.

Country Status (24)

Country Link
JP (2) JP2726320B2 (en)
KR (1) KR0156541B1 (en)
AT (1) AT403476B (en)
AU (1) AU633859B2 (en)
BE (1) BE1002296A5 (en)
CA (1) CA2004532C (en)
CH (1) CH678329A5 (en)
DE (1) DE3991505B4 (en)
DK (1) DK175338B1 (en)
ES (1) ES2023533A6 (en)
FI (1) FI102540B1 (en)
FR (1) FR2639947B1 (en)
GB (1) GB2225579B (en)
HK (1) HK189995A (en)
HU (2) HUT53375A (en)
IE (1) IE62091B1 (en)
IL (1) IL92534A (en)
LU (1) LU87633A1 (en)
MY (1) MY106120A (en)
NL (1) NL194828C (en)
PT (1) PT92487B (en)
SA (1) SA96160495B1 (en)
SE (1) SE508799C2 (en)
WO (1) WO1990006949A2 (en)

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GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
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US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
DE69229436T2 (en) * 1991-02-08 1999-11-25 Biomeasure Inc USE OF SOMATOSTATIN ANALOGS FOR TREATING MELANOMAS
CA2102633A1 (en) * 1991-06-03 1992-12-04 Peter H. Cox Radiolabelled somatostatin derivatives, their preparation and use
CA2113995C (en) * 1991-08-29 2003-04-22 Edward A. Deutsch Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
WO1993012819A1 (en) * 1992-01-03 1993-07-08 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
EP0642357B1 (en) * 1992-02-05 2001-07-25 Mallinckrodt Inc. Radiolabelled somatostatin
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
AU3967593A (en) * 1992-03-25 1993-10-21 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
FI940109A (en) * 1993-01-12 1994-10-11 Sandoz Ag peptides
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
WO1994017829A1 (en) * 1993-02-02 1994-08-18 Neorx Corporation Directed biodistribution of small molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
DE69426673T2 (en) * 1993-06-23 2001-09-20 Diatide Inc RADIO-MARKED SOMATOSTATIN DERIVATIVES FOR IMAGING AND THERAPEUTIC USE
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (en) * 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalcohol peptide derivatives
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE19917713A1 (en) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Short-chain peptide-dye conjugates as contrast agents for optical diagnostics
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
DE60231801D1 (en) * 2001-04-23 2009-05-14 Mallinckrodt Inc TC AND RE-LABELED RADIOACTIVE GLYCOSYLATED OCTREOTIDE DERIVATIVES
CN100475271C (en) 2003-08-20 2009-04-08 加利福尼亚大学董事会 Somatostatin analogs with inhibitory activity to growth hormone release
KR101152729B1 (en) * 2003-09-17 2012-06-15 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 Mechanism-based targeted pancreatic beta cell imaging and therapy
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
WO2014081655A1 (en) 2012-11-21 2014-05-30 Serene Oncology, Llc Tin-1 17m comprising somatostatin receptor binding compounds

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CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (en) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (en) * 1985-06-25 1987-01-08 Diamalt Ag NEW SOMATOSTATIN DERIVATIVES
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
DK172629B1 (en) * 1986-02-14 1999-03-22 Nihon Mediphysics Co Ltd Reactive high molecular weight compounds with at least one free amino group, high molecular weight compounds combined with a physiological
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
NL194729C (en) * 1986-10-13 2003-01-07 Novartis Ag Process for the preparation of peptide alcohols via solid phase.
CH679045A5 (en) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
FR2638968B1 (en) * 1988-11-11 1994-10-07 Sandoz Sa NEW THERAPEUTIC USE OF SOMATOSTATIN AND ITS ANALOGS AND DERIVATIVES

Also Published As

Publication number Publication date
FI102540B (en) 1998-12-31
GB2225579A (en) 1990-06-06
SA96160495B1 (en) 2006-08-23
SE8904087L (en) 1991-06-05
SE8904087D0 (en) 1989-12-04
DE3991505B4 (en) 2006-04-20
SE508799C2 (en) 1998-11-09
KR0156541B1 (en) 1998-10-15
KR900009697A (en) 1990-07-05
IL92534A (en) 1994-06-24
WO1990006949A2 (en) 1990-06-28
LU87633A1 (en) 1991-09-18
GB2225579B (en) 1993-03-17
CH678329A5 (en) 1991-08-30
WO1990006949A3 (en) 1990-07-26
HU896359D0 (en) 1990-02-28
JPH02184698A (en) 1990-07-19
CA2004532C (en) 2000-02-22
AU633859B2 (en) 1993-02-11
AU4587189A (en) 1990-06-14
ES2023533A6 (en) 1992-01-16
PT92487A (en) 1990-06-29
HU211468A9 (en) 1995-11-28
DK612689D0 (en) 1989-12-05
FI895809A0 (en) 1989-12-04
JP2726320B2 (en) 1998-03-11
HUT53375A (en) 1990-10-28
IE62091B1 (en) 1994-12-14
BE1002296A5 (en) 1990-11-20
IE893866L (en) 1990-06-05
GB8927255D0 (en) 1990-01-31
DK175338B1 (en) 2004-08-30
NL194828B (en) 2002-12-02
ATA901789A (en) 1997-07-15
FR2639947A1 (en) 1990-06-08
AT403476B (en) 1998-02-25
PT92487B (en) 1996-01-31
HK189995A (en) 1995-12-29
CA2004532A1 (en) 1990-06-05
NL194828C (en) 2003-04-03
DK612689A (en) 1990-06-06
NL8902981A (en) 1990-07-02
JPH1095737A (en) 1998-04-14
JP3686503B2 (en) 2005-08-24
FI102540B1 (en) 1998-12-31
FR2639947B1 (en) 1995-04-21

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