HK189995A - Detectable somatostatin analogues containing a chelating group - Google Patents

Detectable somatostatin analogues containing a chelating group

Info

Publication number
HK189995A
HK189995A HK189995A HK189995A HK189995A HK 189995 A HK189995 A HK 189995A HK 189995 A HK189995 A HK 189995A HK 189995 A HK189995 A HK 189995A HK 189995 A HK189995 A HK 189995A
Authority
HK
Hong Kong
Prior art keywords
chelating group
somatostatin analogues
analogues containing
detectable
detectable somatostatin
Prior art date
Application number
HK189995A
Inventor
Rainer Albert
Eric P Krenning
Steven W J Lamberts
Janos Pless
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of HK189995A publication Critical patent/HK189995A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HK189995A 1988-12-05 1995-12-21 Detectable somatostatin analogues containing a chelating group HK189995A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
HK189995A true HK189995A (en) 1995-12-29

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
HK189995A HK189995A (en) 1988-12-05 1995-12-21 Detectable somatostatin analogues containing a chelating group

Country Status (24)

Country Link
JP (2) JP2726320B2 (en)
KR (1) KR0156541B1 (en)
AT (1) AT403476B (en)
AU (1) AU633859B2 (en)
BE (1) BE1002296A5 (en)
CA (1) CA2004532C (en)
CH (1) CH678329A5 (en)
DE (1) DE3991505B4 (en)
DK (1) DK175338B1 (en)
ES (1) ES2023533A6 (en)
FI (1) FI102540B1 (en)
FR (1) FR2639947B1 (en)
GB (1) GB2225579B (en)
HK (1) HK189995A (en)
HU (2) HUT53375A (en)
IE (1) IE62091B1 (en)
IL (1) IL92534A (en)
LU (1) LU87633A1 (en)
MY (1) MY106120A (en)
NL (1) NL194828C (en)
PT (1) PT92487B (en)
SA (1) SA96160495B1 (en)
SE (1) SE508799C2 (en)
WO (1) WO1990006949A2 (en)

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DE3845000C2 (en) * 1987-07-10 1998-11-19 Novartis Ag Compsn. contg. somatostatin analogues for treating breast cancer
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
JPH05506254A (en) * 1991-02-08 1993-09-16 バイオメジャー，インコーポレイテッド Treatment methods for benign and malignant proliferative skin diseases
WO1992021383A1 (en) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
DK0600992T3 (en) * 1991-08-29 2000-10-09 Mallinckrodt Medical Inc Use of gentisic acid or gentisyl alcohol to stabilize radiolabelled peptides and proteins
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
DE69231586T2 (en) * 1992-01-03 2001-07-19 Rhomed Inc PHARMACEUTICAL APPLICATIONS BASED ON PEPTIDE METAL IONS
DE69330494T2 (en) * 1992-02-05 2002-03-28 Mallinckrodt Inc RADIOACTIVELY MARKED SOMATOSTATIN
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
AU3967593A (en) * 1992-03-25 1993-10-21 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2113121A1 (en) * 1993-01-12 1994-07-13 Rainer Albert Peptides
CA2154667A1 (en) * 1993-02-02 1994-08-18 Linda M. Gustavson Directed biodistribution of small molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
DE69426673T2 (en) * 1993-06-23 2001-09-20 Diatide Inc RADIO-MARKED SOMATOSTATIN DERIVATIVES FOR IMAGING AND THERAPEUTIC USE
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (en) * 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalcohol peptide derivatives
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (en) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Short-chain peptide-dye conjugates as contrast agents for optical diagnostics
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
BR0209074A (en) * 2001-04-23 2004-08-10 Mallinckrodt Inc Radioactive glycosylated octreotide derivatives with tc and re markers
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
WO2005027981A1 (en) * 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
EP2922578B1 (en) 2012-11-21 2018-12-12 Serene, Llc Tin-117m comprising somatostatin receptor binding compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (en) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (en) * 1985-06-25 1987-01-08 Diamalt Ag NEW SOMATOSTATIN DERIVATIVES
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
CH679045A5 (en) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
BE1003762A3 (en) * 1988-11-11 1992-06-09 Sandoz Sa New therapeutic use somatostatin and analogues and derivatives.

Also Published As

Publication number Publication date
FI102540B (en) 1998-12-31
FI102540B1 (en) 1998-12-31
HUT53375A (en) 1990-10-28
CA2004532C (en) 2000-02-22
HU896359D0 (en) 1990-02-28
ES2023533A6 (en) 1992-01-16
GB8927255D0 (en) 1990-01-31
CA2004532A1 (en) 1990-06-05
GB2225579B (en) 1993-03-17
LU87633A1 (en) 1991-09-18
JP2726320B2 (en) 1998-03-11
DK612689A (en) 1990-06-06
WO1990006949A3 (en) 1990-07-26
DK175338B1 (en) 2004-08-30
AU633859B2 (en) 1993-02-11
PT92487A (en) 1990-06-29
JP3686503B2 (en) 2005-08-24
NL8902981A (en) 1990-07-02
HU211468A9 (en) 1995-11-28
KR900009697A (en) 1990-07-05
BE1002296A5 (en) 1990-11-20
SE8904087D0 (en) 1989-12-04
GB2225579A (en) 1990-06-06
MY106120A (en) 1995-03-31
SE8904087L (en) 1991-06-05
JPH02184698A (en) 1990-07-19
FR2639947B1 (en) 1995-04-21
CH678329A5 (en) 1991-08-30
KR0156541B1 (en) 1998-10-15
ATA901789A (en) 1997-07-15
PT92487B (en) 1996-01-31
SA96160495B1 (en) 2006-08-23
IL92534A (en) 1994-06-24
SE508799C2 (en) 1998-11-09
WO1990006949A2 (en) 1990-06-28
IE62091B1 (en) 1994-12-14
NL194828B (en) 2002-12-02
NL194828C (en) 2003-04-03
FR2639947A1 (en) 1990-06-08
DE3991505B4 (en) 2006-04-20
AT403476B (en) 1998-02-25
IE893866L (en) 1990-06-05
DK612689D0 (en) 1989-12-05
AU4587189A (en) 1990-06-14
FI895809A0 (en) 1989-12-04
JPH1095737A (en) 1998-04-14

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Legal Events

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PF Patent in force
PE Patent expired

Effective date: 20091130