CA2004532A1 - Peptide derivatives - Google Patents
Peptide derivativesInfo
- Publication number
- CA2004532A1 CA2004532A1 CA2004532A CA2004532A CA2004532A1 CA 2004532 A1 CA2004532 A1 CA 2004532A1 CA 2004532 A CA2004532 A CA 2004532A CA 2004532 A CA2004532 A CA 2004532A CA 2004532 A1 CA2004532 A1 CA 2004532A1
- Authority
- CA
- Canada
- Prior art keywords
- somatostatin
- peptide derivatives
- detectable element
- amino group
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888828364A GB8828364D0 (en) | 1988-12-05 | 1988-12-05 | Improvements in/relating to organic compounds |
GB8828364 | 1988-12-05 | ||
GB8916115 | 1989-07-13 | ||
GB898916115A GB8916115D0 (en) | 1989-07-13 | 1989-07-13 | Improvements in or relating to organic compounds |
GB8916761 | 1989-07-21 | ||
GB898916761A GB8916761D0 (en) | 1989-07-21 | 1989-07-21 | Improvements in or relating to organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2004532A1 true CA2004532A1 (en) | 1990-06-05 |
CA2004532C CA2004532C (en) | 2000-02-22 |
Family
ID=27264222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002004532A Expired - Lifetime CA2004532C (en) | 1988-12-05 | 1989-12-04 | Peptide derivatives |
Country Status (24)
Country | Link |
---|---|
JP (2) | JP2726320B2 (en) |
KR (1) | KR0156541B1 (en) |
AT (1) | AT403476B (en) |
AU (1) | AU633859B2 (en) |
BE (1) | BE1002296A5 (en) |
CA (1) | CA2004532C (en) |
CH (1) | CH678329A5 (en) |
DE (1) | DE3991505B4 (en) |
DK (1) | DK175338B1 (en) |
ES (1) | ES2023533A6 (en) |
FI (1) | FI102540B (en) |
FR (1) | FR2639947B1 (en) |
GB (1) | GB2225579B (en) |
HK (1) | HK189995A (en) |
HU (2) | HUT53375A (en) |
IE (1) | IE62091B1 (en) |
IL (1) | IL92534A (en) |
LU (1) | LU87633A1 (en) |
MY (1) | MY106120A (en) |
NL (1) | NL194828C (en) |
PT (1) | PT92487B (en) |
SA (1) | SA96160495B1 (en) |
SE (1) | SE508799C2 (en) |
WO (1) | WO1990006949A2 (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU639371B2 (en) * | 1987-07-10 | 1993-07-22 | Novartis Ag | Method of treating breast cancer |
DE3822557C2 (en) * | 1987-07-10 | 1998-07-02 | Ciba Geigy Ag | Medicines containing somatostatins |
GB9111199D0 (en) * | 1991-05-23 | 1991-07-17 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
GB9004017D0 (en) * | 1990-02-22 | 1990-04-18 | Krenning Eric P | Improvements in or relating to organic compounds |
US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
JPH05506254A (en) * | 1991-02-08 | 1993-09-16 | バイオメジャー,インコーポレイテッド | Treatment methods for benign and malignant proliferative skin diseases |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
EP0588905A1 (en) * | 1991-06-03 | 1994-03-30 | Mallinckrodt Medical, Inc. | Radiolabelled somatostatin derivatives, their preparation and use |
JP3853354B2 (en) * | 1991-08-29 | 2006-12-06 | マリンクロッド・インコーポレイテッド | Stabilizers that prevent autoradiolysis of radiolabeled peptides and proteins |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
CA2127284C (en) * | 1992-01-03 | 2002-02-05 | Buck A. Rhodes | Protein- and peptide-metal ion pharmaceutical applications |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
ATE203417T1 (en) * | 1992-02-05 | 2001-08-15 | Mallinckrodt Inc | RADIOACTIVE LABELED SOMATOSTATIN |
US5371184A (en) * | 1992-02-05 | 1994-12-06 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5643549A (en) * | 1992-02-20 | 1997-07-01 | Rhomed Incorporated | Leukostimulatory agent for in vivo leukocyte tagging |
CA2131315A1 (en) * | 1992-03-25 | 1993-09-30 | Geert J. Ensing | Method of intraoperatively detecting and locating tumoral tissues |
US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
US5871711A (en) * | 1992-06-23 | 1999-02-16 | Diatide, Inc. | Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
HUT66294A (en) * | 1993-01-12 | 1994-11-28 | Sandoz Ag | Polypeptides and process for producing them |
US5650134A (en) * | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
WO1994017829A1 (en) * | 1993-02-02 | 1994-08-18 | Neorx Corporation | Directed biodistribution of small molecules |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
US5932189A (en) * | 1994-07-29 | 1999-08-03 | Diatech, Inc. | Cyclic peptide somatostatin analogs |
EP0720621B1 (en) * | 1993-06-23 | 2001-02-07 | Diatide, Inc. | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
CA2190727C (en) * | 1994-05-19 | 2006-07-18 | Sudhakar Kasina | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
US5556939A (en) * | 1994-10-13 | 1996-09-17 | Merck Frosst Canada, Inc. | TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications |
US5632969A (en) * | 1994-10-13 | 1997-05-27 | Merck & Co., Inc. | N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications |
US5830431A (en) * | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
FI965181A (en) | 1996-12-20 | 1998-06-21 | Map Medical Technologies Oy | Polyalcohol peptide derivatives |
US7175953B2 (en) | 1999-04-09 | 2007-02-13 | Institute Fuer Diagnostik Forschung | Short-warp peptide-dye conjugate as contrast agent for optical diagnostic |
US6630570B1 (en) | 1999-04-09 | 2003-10-07 | Insitut für Diagnostikforschung GmbH | Short-chain peptide-dye conjugates as contrast media for optical diagnosis |
DE19917713A1 (en) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Short-chain peptide-dye conjugates as contrast agents for optical diagnostics |
US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
AU2002254691B8 (en) * | 2001-04-23 | 2008-02-14 | Mallinckrodt Inc. | Tc and Re labeler radioactive glycosylated octreotide derivatives |
US7968080B2 (en) | 2003-08-20 | 2011-06-28 | The Regents Of The University Of California | Somatostatin analogs with inhibitory activity to growth hormone release |
WO2005027981A1 (en) * | 2003-09-17 | 2005-03-31 | Board Of Regents, The University Of Texas System | Mechanism-based targeted pancreatic beta cell imaging and therapy |
EP2067786A1 (en) | 2007-12-07 | 2009-06-10 | ITALFARMACO S.p.A. | Novel non selective analogs of somatostatin |
US9480759B2 (en) | 2012-11-21 | 2016-11-01 | Serene, Llc | Tin-117m somatostatin receptor binding compounds and methods |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1222691A (en) * | 1981-12-29 | 1987-06-09 | Wilhelmus T. Goedemans | Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments |
US4652519A (en) * | 1983-02-03 | 1987-03-24 | Yeda Research And Development Company Limited | Bifunctional chelating agents and process for their production |
US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
DE3511206A1 (en) * | 1985-03-28 | 1986-10-09 | Sandoz-Patent-GmbH, 7850 Lörrach | Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives |
HUT42101A (en) * | 1985-01-07 | 1987-06-29 | Sandoz Ag | Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds |
DE3522638A1 (en) * | 1985-06-25 | 1987-01-08 | Diamalt Ag | NEW SOMATOSTATIN DERIVATIVES |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
AU593611B2 (en) * | 1986-02-14 | 1990-02-15 | Nihon Medi-Physics Co., Ltd. | High molecular compounds having amino groups, and their utilization |
US4732974A (en) * | 1986-03-05 | 1988-03-22 | Mallinckrodt, Inc. | Metal ion labeling of carrier molecules |
US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
NL194729C (en) * | 1986-10-13 | 2003-01-07 | Novartis Ag | Process for the preparation of peptide alcohols via solid phase. |
CH679045A5 (en) * | 1987-06-29 | 1991-12-13 | Sandoz Ag | |
US5073541A (en) * | 1987-11-18 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Treatment of small cell lung cancer with somatostatin analogs |
FR2638968B1 (en) * | 1988-11-11 | 1994-10-07 | Sandoz Sa | NEW THERAPEUTIC USE OF SOMATOSTATIN AND ITS ANALOGS AND DERIVATIVES |
-
1989
- 1989-11-29 MY MYPI89001655A patent/MY106120A/en unknown
- 1989-11-30 CH CH2578/90A patent/CH678329A5/de not_active IP Right Cessation
- 1989-11-30 WO PCT/EP1989/001448 patent/WO1990006949A2/en active Application Filing
- 1989-11-30 AT AT0901789A patent/AT403476B/en active
- 1989-11-30 DE DE3991505A patent/DE3991505B4/en not_active Expired - Lifetime
- 1989-12-01 GB GB8927255A patent/GB2225579B/en not_active Expired - Lifetime
- 1989-12-04 IE IE386689A patent/IE62091B1/en not_active IP Right Cessation
- 1989-12-04 NL NL8902981A patent/NL194828C/en not_active IP Right Cessation
- 1989-12-04 PT PT92487A patent/PT92487B/en active IP Right Grant
- 1989-12-04 KR KR1019890018033A patent/KR0156541B1/en not_active IP Right Cessation
- 1989-12-04 IL IL9253489A patent/IL92534A/en not_active IP Right Cessation
- 1989-12-04 AU AU45871/89A patent/AU633859B2/en not_active Expired
- 1989-12-04 FR FR8915993A patent/FR2639947B1/en not_active Expired - Lifetime
- 1989-12-04 HU HU896359A patent/HUT53375A/en unknown
- 1989-12-04 SE SE8904087A patent/SE508799C2/en unknown
- 1989-12-04 JP JP1315124A patent/JP2726320B2/en not_active Expired - Lifetime
- 1989-12-04 CA CA002004532A patent/CA2004532C/en not_active Expired - Lifetime
- 1989-12-04 FI FI895809A patent/FI102540B/en active IP Right Grant
- 1989-12-05 ES ES8904151A patent/ES2023533A6/en not_active Expired - Lifetime
- 1989-12-05 BE BE8901294A patent/BE1002296A5/en not_active IP Right Cessation
- 1989-12-05 LU LU87633A patent/LU87633A1/en unknown
- 1989-12-05 DK DK198906126A patent/DK175338B1/en not_active IP Right Cessation
-
1995
- 1995-06-15 HU HU95P/P00214P patent/HU211468A9/en unknown
- 1995-12-21 HK HK189995A patent/HK189995A/en not_active IP Right Cessation
-
1996
- 1996-01-01 SA SA96160495A patent/SA96160495B1/en unknown
-
1997
- 1997-08-04 JP JP20891597A patent/JP3686503B2/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |