CA2347670A1 - Radiolabeled somatostatin-derived peptides for imaging - Google Patents
Radiolabeled somatostatin-derived peptides for imagingInfo
- Publication number
- CA2347670A1 CA2347670A1 CA002347670A CA2347670A CA2347670A1 CA 2347670 A1 CA2347670 A1 CA 2347670A1 CA 002347670 A CA002347670 A CA 002347670A CA 2347670 A CA2347670 A CA 2347670A CA 2347670 A1 CA2347670 A1 CA 2347670A1
- Authority
- CA
- Canada
- Prior art keywords
- peptides
- somatostatin
- radiolabeled
- analogues
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 4
- 102000005157 Somatostatin Human genes 0.000 title 1
- 108010056088 Somatostatin Proteins 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 229960000553 somatostatin Drugs 0.000 title 1
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 3
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000003439 radiotherapeutic effect Effects 0.000 abstract 3
- WUAPFZMCVAUBPE-NJFSPNSNSA-N 188Re Chemical compound [188Re] WUAPFZMCVAUBPE-NJFSPNSNSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- WUAPFZMCVAUBPE-IGMARMGPSA-N rhenium-186 Chemical compound [186Re] WUAPFZMCVAUBPE-IGMARMGPSA-N 0.000 abstract 2
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 238000000163 radioactive labelling Methods 0.000 abstract 1
- 229940056501 technetium 99m Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Abstract
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic peptide derivatives and analogues of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radaolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (186Re) and rhenium-188 (188Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling anal using such peptides diagnostically and therapeutically in a mammalian body are also provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9233593A | 1993-07-15 | 1993-07-15 | |
| US08/092,335 | 1993-07-15 | ||
| CA002167281A CA2167281C (en) | 1993-07-15 | 1994-06-03 | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002167281A Division CA2167281C (en) | 1993-07-15 | 1994-06-03 | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2347670A1 true CA2347670A1 (en) | 1995-01-05 |
| CA2347670C CA2347670C (en) | 2006-09-12 |
Family
ID=25678306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002347670A Expired - Fee Related CA2347670C (en) | 1993-07-15 | 1994-06-03 | Radiolabeled somatostatin-derived peptides for imaging |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2347670C (en) |
-
1994
- 1994-06-03 CA CA002347670A patent/CA2347670C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2347670C (en) | 2006-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |