ATE337338T1 - Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung - Google Patents
Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendungInfo
- Publication number
- ATE337338T1 ATE337338T1 AT00122241T AT00122241T ATE337338T1 AT E337338 T1 ATE337338 T1 AT E337338T1 AT 00122241 T AT00122241 T AT 00122241T AT 00122241 T AT00122241 T AT 00122241T AT E337338 T1 ATE337338 T1 AT E337338T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- somatostatin
- peptide derivatives
- sup
- radiolabeled
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 4
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 3
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000003439 radiotherapeutic effect Effects 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000000163 radioactive labelling Methods 0.000 abstract 2
- WUAPFZMCVAUBPE-NJFSPNSNSA-N 188Re Chemical compound [188Re] WUAPFZMCVAUBPE-NJFSPNSNSA-N 0.000 abstract 1
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- WUAPFZMCVAUBPE-IGMARMGPSA-N rhenium-186 Chemical compound [186Re] WUAPFZMCVAUBPE-IGMARMGPSA-N 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
- 229940056501 technetium 99m Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1993/006029 WO1994000489A2 (en) | 1992-06-23 | 1993-06-23 | Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses |
| US08/092,355 US6017509A (en) | 1991-11-27 | 1993-07-15 | Radiolabeled somatostatin receptor-binding peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337338T1 true ATE337338T1 (de) | 2006-09-15 |
Family
ID=22232834
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00122241T ATE337338T1 (de) | 1993-06-23 | 1994-06-03 | Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung |
| AT94920076T ATE199089T1 (de) | 1993-06-23 | 1994-06-03 | Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94920076T ATE199089T1 (de) | 1993-06-23 | 1994-06-03 | Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6214316B1 (de) |
| EP (3) | EP1092726B1 (de) |
| AT (2) | ATE337338T1 (de) |
| AU (1) | AU701083B2 (de) |
| CA (1) | CA2167281C (de) |
| DE (2) | DE69426673T2 (de) |
| DK (1) | DK0720621T3 (de) |
| ES (1) | ES2158897T3 (de) |
| GR (1) | GR3035830T3 (de) |
| SG (3) | SG90060A1 (de) |
| WO (1) | WO1995000553A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
| US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5932189A (en) * | 1994-07-29 | 1999-08-03 | Diatech, Inc. | Cyclic peptide somatostatin analogs |
| PT772459E (pt) * | 1994-05-02 | 2003-06-30 | Diatide Inc | Agentes de imagem marcados tecnecio-99m |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5556939A (en) * | 1994-10-13 | 1996-09-17 | Merck Frosst Canada, Inc. | TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| MY147327A (en) * | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
| US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| US6358491B1 (en) * | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| GB0105224D0 (en) | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
| US20020187099A1 (en) * | 2001-05-16 | 2002-12-12 | Rajesh Manchanda | Stabilization of radionuclide-containing compositions |
| AR044852A1 (es) | 2003-06-24 | 2005-10-05 | Novartis Ag | Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina |
| GB0318682D0 (en) * | 2003-08-08 | 2003-09-10 | Novartis Ag | Organic compounds |
| ITMI20040812A1 (it) * | 2004-04-26 | 2004-07-26 | Chemi Spa | Processo per la formazione di legami disofluro in peptidi ciclici |
| WO2006114324A1 (en) * | 2005-04-28 | 2006-11-02 | Schering Ag | Compounds comprising cyclized somatostatin receptor binding peptides |
| EP1717247A1 (de) * | 2005-04-28 | 2006-11-02 | Schering AG | Zyklische Peptide, die sich am Somatostatinrezeptor binden |
| EP2914276A4 (de) * | 2012-11-01 | 2016-07-13 | Ipsen Pharma Sas | Somatostatin-analoga und dimere daraus |
| TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素－多巴胺嵌合體類似物 |
| US9480759B2 (en) | 2012-11-21 | 2016-11-01 | Serene, Llc | Tin-117m somatostatin receptor binding compounds and methods |
| CN110256310A (zh) * | 2019-07-01 | 2019-09-20 | 吉尔生化（上海）有限公司 | 一种n-芴甲氧羰基-s-(4-甲氧基三苯甲基)-l-高半胱氨酸的制备方法 |
| WO2024228936A1 (en) * | 2023-05-03 | 2024-11-07 | Merck Sharp & Dohme Llc | Cyclic peptides as pet imaging agents of granzyme b |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1083143A (en) * | 1976-01-02 | 1980-08-05 | Nedumparambil A. Abraham | Carba derivatives of somatostatin and process therefor |
| CA1126664A (en) | 1979-03-06 | 1982-06-29 | Michael G. Webb | Anti-pollution equipment |
| NZ195303A (en) * | 1979-10-31 | 1984-10-19 | Merck & Co Inc | Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions |
| US4486415A (en) | 1983-08-15 | 1984-12-04 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4522813A (en) * | 1983-10-27 | 1985-06-11 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4725577A (en) | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
| US4650787A (en) | 1985-04-25 | 1987-03-17 | Schally Andrew Victor | Biologically active octapeptides |
| US4585755A (en) * | 1985-04-29 | 1986-04-29 | Merck & Co., Inc. | Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents |
| US4611054A (en) * | 1985-04-29 | 1986-09-09 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| IL80475A (en) | 1985-11-07 | 1993-01-31 | Pfizer | Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them |
| EP0255224A3 (de) * | 1986-06-30 | 1990-04-18 | Merck & Co. Inc. | Cyclische und verbrückt cyclische Analoge von Somatostatin, verwendbar als analgetische Arzneimittel |
| MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
| GB9111199D0 (en) * | 1991-05-23 | 1991-07-17 | Sandoz Ltd | Improvements in or relating to organic compounds |
| IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
| AU664855B2 (en) * | 1991-08-09 | 1995-12-07 | Winfried Kolbeck | Lanthionine bridged peptides |
| DK0629133T3 (da) * | 1992-01-03 | 2001-04-02 | Rhomed Inc | Farmaceutisk anvendelse af peptidmetalioner |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5932189A (en) * | 1994-07-29 | 1999-08-03 | Diatech, Inc. | Cyclic peptide somatostatin analogs |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
-
1994
- 1994-06-03 EP EP00122241A patent/EP1092726B1/de not_active Expired - Lifetime
- 1994-06-03 WO PCT/US1994/006274 patent/WO1995000553A1/en not_active Ceased
- 1994-06-03 AT AT00122241T patent/ATE337338T1/de not_active IP Right Cessation
- 1994-06-03 SG SG9903785A patent/SG90060A1/en unknown
- 1994-06-03 DK DK94920076T patent/DK0720621T3/da active
- 1994-06-03 CA CA002167281A patent/CA2167281C/en not_active Expired - Fee Related
- 1994-06-03 AU AU70990/94A patent/AU701083B2/en not_active Ceased
- 1994-06-03 DE DE69426673T patent/DE69426673T2/de not_active Expired - Fee Related
- 1994-06-03 ES ES94920076T patent/ES2158897T3/es not_active Expired - Lifetime
- 1994-06-03 EP EP94920076A patent/EP0720621B1/de not_active Expired - Lifetime
- 1994-06-03 EP EP00122242A patent/EP1099707A3/de not_active Withdrawn
- 1994-06-03 DE DE69434832T patent/DE69434832D1/de not_active Expired - Lifetime
- 1994-06-03 SG SG9903781A patent/SG93839A1/en unknown
- 1994-06-03 SG SG1996004666A patent/SG48977A1/en unknown
- 1994-06-03 AT AT94920076T patent/ATE199089T1/de not_active IP Right Cessation
-
1999
- 1999-10-19 US US09/420,865 patent/US6214316B1/en not_active Expired - Fee Related
-
2001
- 2001-05-07 GR GR20010400678T patent/GR3035830T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6214316B1 (en) | 2001-04-10 |
| EP0720621A1 (de) | 1996-07-10 |
| EP0720621B1 (de) | 2001-02-07 |
| CA2167281A1 (en) | 1995-01-05 |
| SG90060A1 (en) | 2002-07-23 |
| WO1995000553A1 (en) | 1995-01-05 |
| ES2158897T3 (es) | 2001-09-16 |
| EP1099707A2 (de) | 2001-05-16 |
| AU7099094A (en) | 1995-01-17 |
| ATE199089T1 (de) | 2001-02-15 |
| DE69426673T2 (de) | 2001-09-20 |
| DK0720621T3 (da) | 2001-08-06 |
| SG48977A1 (en) | 1998-05-18 |
| EP1092726A3 (de) | 2002-01-09 |
| CA2167281C (en) | 2001-09-04 |
| EP1092726B1 (de) | 2006-08-23 |
| DE69426673D1 (de) | 2001-03-15 |
| EP1099707A3 (de) | 2002-01-09 |
| AU701083B2 (en) | 1999-01-21 |
| SG93839A1 (en) | 2003-01-21 |
| EP1092726A2 (de) | 2001-04-18 |
| GR3035830T3 (en) | 2001-08-31 |
| DE69434832D1 (de) | 2006-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |