ATE393781T1 - Somatostatin analoge, deren radiomarkierte derivate und deren verwendung - Google Patents
Somatostatin analoge, deren radiomarkierte derivate und deren verwendungInfo
- Publication number
- ATE393781T1 ATE393781T1 AT00992965T AT00992965T ATE393781T1 AT E393781 T1 ATE393781 T1 AT E393781T1 AT 00992965 T AT00992965 T AT 00992965T AT 00992965 T AT00992965 T AT 00992965T AT E393781 T1 ATE393781 T1 AT E393781T1
- Authority
- AT
- Austria
- Prior art keywords
- somatostatin
- compounds
- radiom
- diagnosing
- labeled derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15100199P | 1999-08-27 | 1999-08-27 | |
US09/397,792 US6358491B1 (en) | 1999-08-27 | 1999-09-16 | Somatostatin analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE393781T1 true ATE393781T1 (de) | 2008-05-15 |
Family
ID=26848228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00992965T ATE393781T1 (de) | 1999-08-27 | 2000-08-23 | Somatostatin analoge, deren radiomarkierte derivate und deren verwendung |
Country Status (12)
Country | Link |
---|---|
US (1) | US6358491B1 (de) |
EP (1) | EP1208116B1 (de) |
JP (1) | JP2003517037A (de) |
AT (1) | ATE393781T1 (de) |
AU (1) | AU782873B2 (de) |
CA (1) | CA2383936A1 (de) |
CO (1) | CO5460266A1 (de) |
DE (1) | DE60038739T2 (de) |
ES (1) | ES2305000T3 (de) |
PE (1) | PE20010516A1 (de) |
TW (1) | TWI243178B (de) |
WO (1) | WO2001044177A2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0961591B1 (de) * | 1997-11-24 | 2008-05-14 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Verfahren zum verbessern der anhäufung von radioaktiven verbindungen in gewebe |
EP1283216A1 (de) * | 2001-08-10 | 2003-02-12 | Mallinckrodt Inc. | Alle somatostatinrezeptorsubtypen-bindende Somatostatinanaloge und deren Verwendung |
DE10215336A1 (de) | 2002-03-28 | 2003-10-23 | Schering Ag | N-Methyl-Homocysteine und ihre Verwendung sowie Verfahren zu ihrer Herstellung |
WO2003057214A1 (en) * | 2001-12-28 | 2003-07-17 | Somatocor Pharmaceuticals, Inc. | Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands |
EP2474328A3 (de) * | 2003-09-17 | 2012-07-18 | Board Of Regents, The University Of Texas System | Mechanismusbasierte gezielte pankreatische Betazellenabbildung und Behandlung |
EP1700608A1 (de) | 2005-03-10 | 2006-09-13 | Schering AG | Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette |
WO2006094725A1 (en) * | 2005-03-10 | 2006-09-14 | Bayer Schering Pharma Aktiengesellschaft | Chelators for radioactively labeled conjugates comprising a stabilizing sidechain |
EP1717219A1 (de) * | 2005-04-28 | 2006-11-02 | Schering AG | Orthogonal geschützte bifunktionelle Aminosäure |
WO2006114324A1 (en) * | 2005-04-28 | 2006-11-02 | Schering Ag | Compounds comprising cyclized somatostatin receptor binding peptides |
EP1717247A1 (de) * | 2005-04-28 | 2006-11-02 | Schering AG | Zyklische Peptide, die sich am Somatostatinrezeptor binden |
US20070025910A1 (en) * | 2005-07-29 | 2007-02-01 | Norenberg Jeffrey P | Anticancer therapy |
ES2351569B8 (es) * | 2009-05-07 | 2012-06-20 | Bcn Peptides S.A. | Ligandos peptídicos de receptores de somatostatina. |
RU2528414C1 (ru) * | 2013-01-25 | 2014-09-20 | Закрытое Акционерное Общество "Фарм-Синтез" | Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы |
CN105431447A (zh) * | 2013-03-15 | 2016-03-23 | 阿达拉塔合伙有限公司 | Pcsk9的小分子调节剂和其使用方法 |
EP3160518A4 (de) * | 2014-06-30 | 2018-05-23 | Tarveda Therapeutics, Inc. | Gerichtete konjugate sowie partikel und formulierungen davon |
AU2016343817B2 (en) | 2015-10-28 | 2021-05-27 | Tva (Abc), Llc | SSTR-targeted conjugates and particles and formulations thereof |
PT3568205T (pt) | 2017-01-12 | 2023-10-26 | Radiomedix Inc | Tratamento de células de cancro que sobrexpressam recetores de somatostatina com a utilização de derivados de ocreótido quelado a radioisótopos |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4310518A (en) | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4486415A (en) | 1983-08-15 | 1984-12-04 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4522813A (en) | 1983-10-27 | 1985-06-11 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
EP0222578A3 (de) | 1985-11-06 | 1990-04-04 | Merck & Co. Inc. | Verwendung von cyclischen Somatostatinanaloga zur Behandlung von sofortigen Überempfindlichkeitskrankheiten |
US5776894A (en) | 1988-12-05 | 1998-07-07 | Novartis Ag | Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors |
US5985240A (en) | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5932189A (en) * | 1994-07-29 | 1999-08-03 | Diatech, Inc. | Cyclic peptide somatostatin analogs |
ES2158897T3 (es) * | 1993-06-23 | 2001-09-16 | Diatide Inc | Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos. |
GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
US5597894A (en) | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
US5770687A (en) | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
US5830431A (en) | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
MY147327A (en) | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
US5708135A (en) | 1995-09-29 | 1998-01-13 | Biomeasure Incorporated | Cyclic peptide analogs of somatostatin |
AT405906B (de) | 1997-03-14 | 1999-12-27 | Irene Dr Virgolini | Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie |
-
1999
- 1999-09-16 US US09/397,792 patent/US6358491B1/en not_active Expired - Lifetime
-
2000
- 2000-08-18 TW TW089116770A patent/TWI243178B/zh not_active IP Right Cessation
- 2000-08-22 PE PE2000000852A patent/PE20010516A1/es not_active Application Discontinuation
- 2000-08-23 AT AT00992965T patent/ATE393781T1/de not_active IP Right Cessation
- 2000-08-23 ES ES00992965T patent/ES2305000T3/es not_active Expired - Lifetime
- 2000-08-23 JP JP2001545265A patent/JP2003517037A/ja active Pending
- 2000-08-23 DE DE60038739T patent/DE60038739T2/de not_active Expired - Lifetime
- 2000-08-23 EP EP00992965A patent/EP1208116B1/de not_active Expired - Lifetime
- 2000-08-23 WO PCT/IB2000/002072 patent/WO2001044177A2/en active IP Right Grant
- 2000-08-23 AU AU48659/01A patent/AU782873B2/en not_active Ceased
- 2000-08-23 CA CA002383936A patent/CA2383936A1/en not_active Abandoned
- 2000-08-24 CO CO00063458A patent/CO5460266A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU782873B2 (en) | 2005-09-08 |
TWI243178B (en) | 2005-11-11 |
JP2003517037A (ja) | 2003-05-20 |
WO2001044177A2 (en) | 2001-06-21 |
EP1208116A2 (de) | 2002-05-29 |
DE60038739D1 (de) | 2008-06-12 |
CA2383936A1 (en) | 2001-06-21 |
US6358491B1 (en) | 2002-03-19 |
PE20010516A1 (es) | 2001-04-29 |
EP1208116B1 (de) | 2008-04-30 |
ES2305000T3 (es) | 2008-11-01 |
DE60038739T2 (de) | 2009-05-20 |
WO2001044177A3 (en) | 2002-03-28 |
AU4865901A (en) | 2001-06-25 |
CO5460266A1 (es) | 2004-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE393781T1 (de) | Somatostatin analoge, deren radiomarkierte derivate und deren verwendung | |
IL140622A0 (en) | Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof | |
CY1105879T1 (el) | Αζαδικυκλο παραγωγα ως ανταγωνιστες μουσκαρινικου υποδοχεα | |
NO20022655D0 (no) | <Beta>-2-adrenerge reseptoragonister | |
ATE480252T1 (de) | Peptidantagonist von zonulin und dessen verwendung | |
DE602004012858D1 (de) | 2-aminobenzothiazole als cb1 rezeptor inverse agonisten | |
DK1054887T3 (da) | Bicykliske pyridin- og pyrimidinderivater som neuropeptid Y-receptorantagonister | |
BR0208179A (pt) | Composto, composição farmacêutica, métodos para tratar distúrbios associados com o receptor 5-ht6, distúrbios cognitivos, distúrbios da mémoria, psicose, esquizofrenia, e ansiedade, e, uso de um composto | |
AUPO755097A0 (en) | Receptor agonist and antagonist | |
EA200400816A1 (ru) | Замещенные аналоги хиназолин-4-иламина в качестве модуляторов капсаицина | |
DE69728585D1 (de) | Mittel gegen Juckreiz | |
EP1383919A4 (de) | Verfahren und zusammensetzungen zur verwendung von mhc-klasse ii-invariante-kette-polypeptid als rezeptor für makrophagenwanderung-hemmfaktor | |
HK1082200A1 (en) | Compositions and methods for the therapy of inflammatory bowel disease | |
EP1109542A4 (de) | Nitrosierte und nitrosylierte antagonisten des alpha-adrenergischen rezeptors, zusammenstellungen und verwendungsmethoden | |
TR200100267T2 (tr) | İkameli anilid bileşimleri ve yöntemler. | |
EP1461061A4 (de) | Zusammensetzungen und verfahren zum nachweis und zur behandlung von krankheiten und zuständen im zusammenhang mit chemokine-rezeptoren | |
DK1085896T3 (da) | Somatostatinanaloger cykliseret med konformationelt begrænset skelet | |
ATE481103T1 (de) | Derivate von 2-(8,9-dioxo-2,6- diazabicyclo(5.2.0)non-1(7)-en-2- yl)alkylphosphonsäure und deren verwendung als n- methyl-d-aspartat- (nmda-) rezeptorantagonisten | |
ATE356623T1 (de) | 5-ht3-rezeptorantagonisten und verwendungsverfahren | |
ATE429421T1 (de) | Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten | |
EA200000198A1 (ru) | 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов | |
NO20002408D0 (no) | 5-HT1F antagonister | |
SE0303418D0 (sv) | New use 1 | |
WO2003104395A3 (en) | RECEPTORS AND PROTEINS ASSOCIATED WITH A MEMBRANE- | |
SE0303488D0 (sv) | New use 1X |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |