ME00973B - Humana antitjela prema humanom cd20 i postupak njihovog korišćenja - Google Patents

Humana antitjela prema humanom cd20 i postupak njihovog korišćenja

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Publication number
ME00973B
ME00973B MEP-2010-15A MEP1510A ME00973B ME 00973 B ME00973 B ME 00973B ME P1510 A MEP1510 A ME P1510A ME 00973 B ME00973 B ME 00973B
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ME
Montenegro
Prior art keywords
human
antibody
antigen
fold
diseases
Prior art date
Application number
MEP-2010-15A
Other languages
English (en)
French (fr)
Inventor
Joel H Martin
Li-Hsien Wang
Sean Stevens
Erin M Allison
Original Assignee
Regeneron Pharma
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Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of ME00973B publication Critical patent/ME00973B/me

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology

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Abstract

Humano antitijelo ili antigen-vezujući fragment antitijela koji specifično vezuje humani CD20, u stanju je da indukuje citotoksičnost zavisnu od komplementa (CDC) i može produžiti vrijeme preživljavanja bez simptoma između oko 2-puta do oko 9-puta ili više u  odnosu na životinje tretirane kontrolom. na mišjem modelu humanog limfoma. Antitijelo ili njihov fragment koji vezuje antigen, koristan je u terapeutskom postupku za liječenje bolesti ili stanja, posredovanih sa CD20, kao što je, primjera radi, non-Hodgkinov limfom,  reumatoidni artritis, sistemski lupus eritematozus, Crohnova bolest, hronična limfocitna leukemija i inflamatorne bolesti.
MEP-2010-15A 2007-07-31 2008-07-31 Humana antitjela prema humanom cd20 i postupak njihovog korišćenja ME00973B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96281107P 2007-07-31 2007-07-31
US6799408P 2008-03-03 2008-03-03
PCT/US2008/071709 WO2009018411A1 (en) 2007-07-31 2008-07-31 Human antibodies to human cd20 and method of using thereof

Publications (1)

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ME00973B true ME00973B (me) 2012-06-20

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US (3) US7879984B2 (me)
EP (1) EP2178916B1 (me)
JP (1) JP5588865B2 (me)
KR (1) KR101561020B1 (me)
CN (1) CN101809037B (me)
AU (1) AU2008282152B2 (me)
BR (1) BRPI0813985B1 (me)
CA (1) CA2695199C (me)
CO (1) CO6260105A2 (me)
CR (1) CR11243A (me)
DK (1) DK2178916T3 (me)
DO (1) DOP2010000037A (me)
EC (1) ECSP10010005A (me)
ES (1) ES2527297T3 (me)
GT (1) GT201000026A (me)
HK (1) HK1141811A1 (me)
HN (1) HN2010000202A (me)
MA (1) MA31634B1 (me)
ME (1) ME00973B (me)
MX (1) MX2010000970A (me)
MY (1) MY147651A (me)
NI (1) NI201000016A (me)
NZ (1) NZ583019A (me)
PL (1) PL2178916T3 (me)
RU (1) RU2486205C2 (me)
SV (1) SV2010003468A (me)
TN (2) TN2010000054A1 (me)
WO (1) WO2009018411A1 (me)
ZA (1) ZA201000545B (me)

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