MX2020013062A - Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso. - Google Patents

Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso.

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Publication number
MX2020013062A
MX2020013062A MX2020013062A MX2020013062A MX2020013062A MX 2020013062 A MX2020013062 A MX 2020013062A MX 2020013062 A MX2020013062 A MX 2020013062A MX 2020013062 A MX2020013062 A MX 2020013062A MX 2020013062 A MX2020013062 A MX 2020013062A
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Mexico
Prior art keywords
gitr
antibodies
activity
human
present disclosure
Prior art date
Application number
MX2020013062A
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English (en)
Inventor
Olivier Leger
Gerd Ritter
Dennis J Underwood
David Schaer
Jedd David Wolchok
Volker Seibert
Taha Merghoub
Dijk Marc Van
Takemasa Tsuji
Ana M Gonzalez
Nicolas S Wilson
Roberta Zappasodi
Original Assignee
Agenus Inc
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Publication date
Application filed by Agenus Inc filed Critical Agenus Inc
Publication of MX2020013062A publication Critical patent/MX2020013062A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

La presente descripción proporciona anticuerpos que se unen específicamente al receptor relacionado con la familia de TNFR inducido por glucocorticoides (GITR) y composiciones que comprenden los anticuerpos. En un aspecto específico, los anticuerpos se unen específicamente al GITR humano y modulan la actividad del GITR, por ejemplo, aumentan, activan o inducen actividad GITR, mediante el uso de los anticuerpos. La presente descripción también proporciona métodos para tratar trastornos, tales como cáncer y enfermedades infecciosas, mediante la administración de un anticuerpo que se une específicamente al GITR humano y modula la actividad GITR, por ejemplo, mejora, activa o induce actividad GITR.
MX2020013062A 2014-05-28 2016-11-28 Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso. MX2020013062A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462004071P 2014-05-28 2014-05-28
US201562161250P 2015-05-13 2015-05-13

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MX2020013062A true MX2020013062A (es) 2021-03-02

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MX2016015614A MX2016015614A (es) 2014-05-28 2015-05-28 Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso.
MX2020013062A MX2020013062A (es) 2014-05-28 2016-11-28 Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso.

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