BR112019010356A2 - molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduo - Google Patents
molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduoInfo
- Publication number
- BR112019010356A2 BR112019010356A2 BR112019010356A BR112019010356A BR112019010356A2 BR 112019010356 A2 BR112019010356 A2 BR 112019010356A2 BR 112019010356 A BR112019010356 A BR 112019010356A BR 112019010356 A BR112019010356 A BR 112019010356A BR 112019010356 A2 BR112019010356 A2 BR 112019010356A2
- Authority
- BR
- Brazil
- Prior art keywords
- cancer
- antibody
- individual
- drug
- composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 229940127121 immunoconjugate Drugs 0.000 title abstract 3
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 2
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- 150000001720 carbohydrates Chemical class 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 230000008105 immune reaction Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 208000003445 Mouth Neoplasms Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 206010004593 Bile duct cancer Diseases 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 206010014733 Endometrial cancer Diseases 0.000 abstract 1
- 206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 abstract 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 abstract 1
- 208000008839 Kidney Neoplasms Diseases 0.000 abstract 1
- 206010023825 Laryngeal cancer Diseases 0.000 abstract 1
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 abstract 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 abstract 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 abstract 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010038389 Renal cancer Diseases 0.000 abstract 1
- 206010039491 Sarcoma Diseases 0.000 abstract 1
- 208000000453 Skin Neoplasms Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000024313 Testicular Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 208000026900 bile duct neoplasm Diseases 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 208000006990 cholangiocarcinoma Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000003238 esophagus Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 201000010175 gallbladder cancer Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 201000010536 head and neck cancer Diseases 0.000 abstract 1
- 208000014829 head and neck neoplasm Diseases 0.000 abstract 1
- 201000002313 intestinal cancer Diseases 0.000 abstract 1
- 201000010982 kidney cancer Diseases 0.000 abstract 1
- 206010023841 laryngeal neoplasm Diseases 0.000 abstract 1
- 201000004962 larynx cancer Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 201000006958 oropharynx cancer Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 201000003120 testicular cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
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Abstract
são descritos conjugados fármaco-anticorpo (adcs) compreendendo um conjugado de fármaco ao anticorpo ou fragmentos de ligação ao antígeno dos mesmos que se ligam ao antígeno da série globo descritos aqui, bem como métodos de uso dos mesmos. os métodos de uso incluem, sem limitação, terapias de câncer e diagnóstico. os anticorpos da descrição podem se ligar a certas superfícies das células de câncer. exemplos de alvos de anticorpos descritos aqui podem incluir carcinomas, tais como sarcoma, câncer de pele, leucemia, linfoma, câncer cerebral, glioblastoma, câncer de pulmão, câncer de mama, câncer oral, câncer de cabeça e pescoço, câncer nasofaringeal, câncer de esôfago, câncer de estômago, câncer de fígado, câncer de duto biliar, câncer da vesícula biliar, câncer de bexiga, câncer pancreático, câncer intestinal, câncer coloretal, câncer de rim, câncer do colo de útero, câncer endometrial, câncer ovariano, câncer de testículo, câncer de boca, câncer orofaringe, câncer de laringe e câncer de próstata.
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TW201834695A (zh) | 2018-10-01 |
KR20190077103A (ko) | 2019-07-02 |
TWI767959B (zh) | 2022-06-21 |
AU2017361549B2 (en) | 2023-12-21 |
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EP3541414A1 (en) | 2019-09-25 |
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CA3044274A1 (en) | 2018-05-24 |
TWI822055B (zh) | 2023-11-11 |
AU2017361549A1 (en) | 2019-06-06 |
US11000601B2 (en) | 2021-05-11 |
EP3541414A4 (en) | 2020-11-11 |
US12090212B2 (en) | 2024-09-17 |
TW202233250A (zh) | 2022-09-01 |
EP3541414B1 (en) | 2024-08-28 |
CN110290800A (zh) | 2019-09-27 |
IL266693A (en) | 2019-07-31 |
JP2019535731A (ja) | 2019-12-12 |
US20210113711A1 (en) | 2021-04-22 |
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