BR112019010356A2 - molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduo - Google Patents

molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduo

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Publication number
BR112019010356A2
BR112019010356A2 BR112019010356A BR112019010356A BR112019010356A2 BR 112019010356 A2 BR112019010356 A2 BR 112019010356A2 BR 112019010356 A BR112019010356 A BR 112019010356A BR 112019010356 A BR112019010356 A BR 112019010356A BR 112019010356 A2 BR112019010356 A2 BR 112019010356A2
Authority
BR
Brazil
Prior art keywords
cancer
antibody
individual
drug
composition
Prior art date
Application number
BR112019010356A
Other languages
English (en)
Inventor
Chen I-Ju
Lai Jiann-Shiun
Chen Kai-Chuan
Nientse Chang Michael
Li Wan-Fen
Tsai Yi-Chien
Original Assignee
Obi Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obi Pharma Inc filed Critical Obi Pharma Inc
Publication of BR112019010356A2 publication Critical patent/BR112019010356A2/pt

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Abstract

são descritos conjugados fármaco-anticorpo (adcs) compreendendo um conjugado de fármaco ao anticorpo ou fragmentos de ligação ao antígeno dos mesmos que se ligam ao antígeno da série globo descritos aqui, bem como métodos de uso dos mesmos. os métodos de uso incluem, sem limitação, terapias de câncer e diagnóstico. os anticorpos da descrição podem se ligar a certas superfícies das células de câncer. exemplos de alvos de anticorpos descritos aqui podem incluir carcinomas, tais como sarcoma, câncer de pele, leucemia, linfoma, câncer cerebral, glioblastoma, câncer de pulmão, câncer de mama, câncer oral, câncer de cabeça e pescoço, câncer nasofaringeal, câncer de esôfago, câncer de estômago, câncer de fígado, câncer de duto biliar, câncer da vesícula biliar, câncer de bexiga, câncer pancreático, câncer intestinal, câncer coloretal, câncer de rim, câncer do colo de útero, câncer endometrial, câncer ovariano, câncer de testículo, câncer de boca, câncer orofaringe, câncer de laringe e câncer de próstata.
BR112019010356A 2016-11-21 2017-11-21 molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduo BR112019010356A2 (pt)

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