CY1118693T1 - Αντισωματα αντι-ακτιβινης α και χρησεις αυτων - Google Patents

Αντισωματα αντι-ακτιβινης α και χρησεις αυτων

Info

Publication number
CY1118693T1
CY1118693T1 CY20161101023T CY161101023T CY1118693T1 CY 1118693 T1 CY1118693 T1 CY 1118693T1 CY 20161101023 T CY20161101023 T CY 20161101023T CY 161101023 T CY161101023 T CY 161101023T CY 1118693 T1 CY1118693 T1 CY 1118693T1
Authority
CY
Cyprus
Prior art keywords
activin
antibodies
derivatives
polypeptides
fragments
Prior art date
Application number
CY20161101023T
Other languages
English (en)
Inventor
Hq Han
Qing Chen
Keith Soo-Nyung Kwak
Xiaolan Zhou
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39103486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118693(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1118693T1 publication Critical patent/CY1118693T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η αποκάλυψη παρέχει συνθέσεις και μεθόδους που σχετίζονται με ή παράγονται από πρωτεΐνες σύνδεσης αντι-ακτιβίνης Α, συμπεριλαμβανομένων των αντισωμάτων. Σε συγκεκριμένες ενσωματώσεις, η αποκάλυψη παρέχει εντελώς ανθρώπινα, ανθρωποποιημένα και χιμαιρικά αντισώματα αντι-ακτιβίνης Α, τα οποία συνδέονται με ανθρώπινη ακτιβίνη Α, θραύσματα σύνδεσης ακτιβίνης Α και παράγωγα αυτών των αντισωμάτων, και πολυπεπτίδια σύνδεσης ακτιβίνης Α που περιλαμβάνουν τέτοια θραύσματα. Άλλες ενσωματώσεις παρέχουν νουκλεϊνικά οξέα που κωδικοποιούν αυτά τα αντισώματα, τα θραύσματα αντισώματος και τα παράγωγα και τα πολυπεπτίδια, κύτταρα που περιλαμβάνουν αυτά τα πολυνουκλεοτίδια, μεθόδους παρασκευής αυτών των αντισωμάτων, των θραυσμάτων αντισώματος και των παραγώγων και των πολυπεπτιδίων, και μεθόδους χρήσης αυτών των αντισωμάτων, των θραυσμάτων αντισώματος και των παραγώγων και των πολυπεπτιδίων, συμπεριλαμβανομένων μεθόδων θεραπείας ή διάγνωσης υποκειμένων που πάσχουν από διαταραχές ή παθήσεις που σχετίζονται με ακτιβίνη Α συμπεριλαμβανομένης της καχεξίας που σχετίζεται με γοναδικό καρκίνο, άλλων καρκίνων, ρευματοειδούς αρθρίτιδας και άλλων παθήσεων.
CY20161101023T 2006-09-08 2016-10-13 Αντισωματα αντι-ακτιβινης α και χρησεις αυτων CY1118693T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84343006P 2006-09-08 2006-09-08
US95665307P 2007-08-17 2007-08-17
EP07842088.2A EP2064239B1 (en) 2006-09-08 2007-09-07 Anti-activin a antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CY1118693T1 true CY1118693T1 (el) 2017-07-12

Family

ID=39103486

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20151100092T CY1116037T1 (el) 2006-09-08 2015-01-29 Αντισωματα κατα της ακτιβινης α και χρησεις αυτων
CY20161101023T CY1118693T1 (el) 2006-09-08 2016-10-13 Αντισωματα αντι-ακτιβινης α και χρησεις αυτων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20151100092T CY1116037T1 (el) 2006-09-08 2015-01-29 Αντισωματα κατα της ακτιβινης α και χρησεις αυτων

Country Status (22)

Country Link
US (5) US8309082B2 (el)
EP (5) EP3730517A1 (el)
JP (3) JP5497438B2 (el)
AR (1) AR062703A1 (el)
AU (1) AU2007294580C1 (el)
CA (1) CA2661878C (el)
CL (1) CL2007002567A1 (el)
CY (2) CY1116037T1 (el)
DK (2) DK2559705T3 (el)
ES (2) ES2528798T3 (el)
HR (2) HRP20150171T1 (el)
HU (1) HUE030463T2 (el)
LT (1) LT2559705T (el)
ME (1) ME02539B (el)
MX (1) MX2009002571A (el)
PE (1) PE20080914A1 (el)
PL (2) PL2559705T3 (el)
PT (2) PT2559705T (el)
RS (2) RS55100B1 (el)
SI (2) SI2064239T1 (el)
TW (1) TW200819466A (el)
WO (1) WO2008031061A2 (el)

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