CY1118845T1 - Πρωτεϊνες συνδεσης αντιγονου υποδοχεα α il-17 - Google Patents

Πρωτεϊνες συνδεσης αντιγονου υποδοχεα α il-17

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Publication number
CY1118845T1
CY1118845T1 CY20171100296T CY171100296T CY1118845T1 CY 1118845 T1 CY1118845 T1 CY 1118845T1 CY 20171100296 T CY20171100296 T CY 20171100296T CY 171100296 T CY171100296 T CY 171100296T CY 1118845 T1 CY1118845 T1 CY 1118845T1
Authority
CY
Cyprus
Prior art keywords
binding proteins
antibodies
receptor
antigen concentration
concentration binding
Prior art date
Application number
CY20171100296T
Other languages
English (en)
Inventor
Joel Tocker
Jacques J Peschon
David Fitzpatrick
Ai Ching Lim
Christopher Mehlin
James F Smothers
Original Assignee
Kirin-Amgen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin-Amgen, Inc. filed Critical Kirin-Amgen, Inc.
Publication of CY1118845T1 publication Critical patent/CY1118845T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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  • Virology (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε πρωτεΐνες σύνδεσης αντιγόνου υποδοχέα A IL-17 (IL-17RA ή IL-17R), όπως αντισώματα, αλληλουχίες πολυνουκλεοτιδίου που κωδικοποιούν τις εν λόγω πρωτεΐνες σύνδεσης αντιγόνου και συνθέσεις και μεθόδους για διάγνωση και θεραπεία ασθενειών που προκαλούνται από ενεργοποίηση υποδοχέα IL-17 με έναν ή περισσότερους συνδέτες IL-17. Η παρούσα εφεύρεση αφορά στην πιστοποίηση εξουδετερωτικών προσδιοριστών επί υποδοχέα A IL-17 (IL-17RA ή IL-17R) και αντισώματα που συνδέονται προς αυτούς. Απόψεις της εφεύρεσης επίσης περιλαμβάνουν αντισώματα που ανταγωνίζονται για σύνδεση με τα IL-17RA εξουδετερωτικά αντισώματα που περιγράφονται στο παρόν.
CY20171100296T 2006-10-02 2017-03-07 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα α il-17 CY1118845T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82788206P 2006-10-02 2006-10-02
US87307206P 2006-12-05 2006-12-05
US96989507P 2007-09-04 2007-09-04
EP07867194.8A EP2076541B1 (en) 2006-10-02 2007-10-01 Il-17 receptor a antigen binding proteins

Publications (1)

Publication Number Publication Date
CY1118845T1 true CY1118845T1 (el) 2018-01-10

Family

ID=39344834

Family Applications (5)

Application Number Title Priority Date Filing Date
CY20151100442T CY1116291T1 (el) 2006-10-02 2015-05-18 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17
CY20171100296T CY1118845T1 (el) 2006-10-02 2017-03-07 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα α il-17
CY20171100544T CY1118994T1 (el) 2006-10-02 2017-05-25 Πρωτεϊνες συνδεσης αντιγονου il-17 υποδοχεα α
CY2018001C CY2018001I1 (el) 2006-10-02 2018-01-15 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17
CY20221100181T CY1125133T1 (el) 2006-10-02 2022-03-02 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20151100442T CY1116291T1 (el) 2006-10-02 2015-05-18 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17

Family Applications After (3)

Application Number Title Priority Date Filing Date
CY20171100544T CY1118994T1 (el) 2006-10-02 2017-05-25 Πρωτεϊνες συνδεσης αντιγονου il-17 υποδοχεα α
CY2018001C CY2018001I1 (el) 2006-10-02 2018-01-15 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17
CY20221100181T CY1125133T1 (el) 2006-10-02 2022-03-02 Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17

Country Status (30)

Country Link
US (15) US7833527B2 (el)
EP (4) EP2076541B1 (el)
JP (1) JP5013383B2 (el)
KR (2) KR101240903B1 (el)
CN (1) CN103214576B (el)
AR (1) AR063090A1 (el)
AU (2) AU2007314519C1 (el)
BR (1) BRPI0719762B8 (el)
CA (1) CA2663537C (el)
CL (1) CL2007002800A1 (el)
CR (1) CR10760A (el)
CY (5) CY1116291T1 (el)
DK (4) DK2076541T3 (el)
EA (1) EA019397B1 (el)
ES (4) ES2906774T3 (el)
HU (4) HUE033216T2 (el)
IL (3) IL197636B (el)
LT (4) LT2487188T (el)
LU (1) LUC00056I2 (el)
MX (1) MX2009003511A (el)
MY (1) MY187263A (el)
NL (1) NL300919I2 (el)
NO (2) NO344867B1 (el)
NZ (1) NZ575631A (el)
PE (2) PE20081625A1 (el)
PL (4) PL2518085T3 (el)
PT (4) PT3165539T (el)
SI (4) SI2076541T1 (el)
TW (1) TWI396694B (el)
WO (1) WO2008054603A2 (el)

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US7833527B2 (en) * 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
WO2008106131A2 (en) * 2007-02-28 2008-09-04 Schering Corporation Combination therapy for treatment of immune disorders
WO2008156709A1 (en) * 2007-06-13 2008-12-24 Amgen Inc. Il-17 heteromeric receptor complex
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BRPI0907196B1 (pt) * 2008-02-21 2021-05-25 Kirin-Amgen Inc Uso de um antagonista de il-17ra-il-17rb
EP2356140A2 (en) * 2008-10-07 2011-08-17 Novimmune Sa Il-17-mediated transfection methods
WO2010062858A1 (en) * 2008-11-26 2010-06-03 Allergan, Inc. Il-17 antibody inhibitor for treating dry eye
US8211434B2 (en) 2008-11-26 2012-07-03 Allergan, Inc. KLK-13 antibody inhibitor for treating dry eye
BRPI1013688A8 (pt) 2009-03-05 2017-02-14 Abbott Lab Proteínas de ligação de il-17.
MX2011009798A (es) 2009-03-20 2011-12-08 Amgen Inc Inmunoglobulinas portadoras y usos de las mismas.
MX2011011729A (es) 2009-05-05 2012-04-10 Novimmune Sa Anticuerpo anti il-17f y metodos de uso de los mismos.
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