CY1119641T1 - Μεθοδοι κατασκευης ανοσοσφαιρινων - Google Patents

Μεθοδοι κατασκευης ανοσοσφαιρινων

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Publication number
CY1119641T1
CY1119641T1 CY20171101260T CY171101260T CY1119641T1 CY 1119641 T1 CY1119641 T1 CY 1119641T1 CY 20171101260 T CY20171101260 T CY 20171101260T CY 171101260 T CY171101260 T CY 171101260T CY 1119641 T1 CY1119641 T1 CY 1119641T1
Authority
CY
Cyprus
Prior art keywords
immunoglobulin
modified
epitope
structural loops
nucleic acid
Prior art date
Application number
CY20171101260T
Other languages
English (en)
Inventor
Gottfried Himmler
Gerda Redl
Florian RÜCKER
Gordana Wozniak-Knopp
Original Assignee
F-Star Biotechnologische Forschungs-Und Entwicklungsges.M.B.H.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F-Star Biotechnologische Forschungs-Und Entwicklungsges.M.B.H. filed Critical F-Star Biotechnologische Forschungs-Und Entwicklungsges.M.B.H.
Publication of CY1119641T1 publication Critical patent/CY1119641T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μέθοδο κατασκευής ανοσοσφαιρίνης που περιλαμβάνει μεταβλητή περιοχή και τουλάχιστον μία τροποποίηση σε τουλάχιστον δύο δομικούς βρόχους αυτής της ανοσοσφαιρίνης και καθορισμού της δέσμευσης αυτής της ανοσοσφαιρίνης σε επίτοπο αντιγόνου, όπου η μη-τροποποιημένη ανοσοσφαιρίνη δεν δεσμεύεται σημαντικά σε αυτόν τον επίτοπο, η οποία περιλαμβάνει τα στάδια: παροχής νουκλεϊκού οξέος που κωδικοποιεί ανοσοσφαιρίνη που περιλαμβάνει τουλάχιστον δύο δομικούς βρόχους, τροποποίησης τουλάχιστον ενός υπολείμματος νουκλεοτιδίου του καθενός από αυτούς τους δομικούς βρόχους, μεταφοράς αυτού του τροποποιημένου νουκλεϊκού οξέος σε σύστημα έκφρασης, έκφρασης αυτής της τροποποιημένης ανοσοσφαιρίνης, επαφής της εκφραζόμενης τροποποιημένης ανοσοσφαιρίνης με επίτοπο, και καθορισμού του εάν αυτή η τροποποιημένη ανοσοσφαιρίνη δεσμεύεται με αυτόν τον επίτοπο, ανοσοσφαιρινών που παράγονται από τέτοια μέθοδο και βιβλιοθηκών ανοσοσφαιρινών.
CY20171101260T 2006-07-05 2017-11-30 Μεθοδοι κατασκευης ανοσοσφαιρινων CY1119641T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0114506A AT503902B1 (de) 2006-07-05 2006-07-05 Verfahren zur manipulation von immunglobulinen
PCT/AT2007/000343 WO2008003116A2 (en) 2006-07-05 2007-07-05 Method for engineering immunoglobulins

Publications (1)

Publication Number Publication Date
CY1119641T1 true CY1119641T1 (el) 2018-04-04

Family

ID=38871148

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171101260T CY1119641T1 (el) 2006-07-05 2017-11-30 Μεθοδοι κατασκευης ανοσοσφαιρινων

Country Status (15)

Country Link
US (4) US9133274B2 (el)
EP (2) EP2044117B1 (el)
JP (1) JP5508002B2 (el)
CN (2) CN101528775A (el)
AT (1) AT503902B1 (el)
CY (1) CY1119641T1 (el)
DK (1) DK2044117T3 (el)
ES (2) ES2968247T3 (el)
HK (1) HK1251239A1 (el)
HU (1) HUE037426T2 (el)
LT (1) LT2044117T (el)
PL (1) PL2044117T3 (el)
PT (1) PT2044117T (el)
SI (1) SI2044117T1 (el)
WO (1) WO2008003116A2 (el)

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