US10131710B2 - Optimized antibody variable regions - Google Patents

Optimized antibody variable regions Download PDF

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Publication number
US10131710B2
US10131710B2 US14/207,489 US201414207489A US10131710B2 US 10131710 B2 US10131710 B2 US 10131710B2 US 201414207489 A US201414207489 A US 201414207489A US 10131710 B2 US10131710 B2 US 10131710B2
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US
United States
Prior art keywords
antibody
variants
anti
amino acid
fc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US14/207,489
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US20140377270A1 (en
Inventor
Gregory Moore
Matthew Bernett
Rumana Rashid
John Desjarlais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
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Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority to US201361752348P priority Critical
Priority to US201361764954P priority
Priority to US201361778148P priority
Priority to US201361778157P priority
Priority to US201361780334P priority
Priority to US201361780310P priority
Priority to US201361794695P priority
Priority to US201361794896P priority
Priority to US201361818401P priority
Priority to US201361818410P priority
Priority to US201361818344P priority
Priority to US201361818153P priority
Priority to US201361913832P priority
Priority to US201361913870P priority
Priority to US201361913879P priority
Priority to US14/155,334 priority patent/US20140370013A1/en
Priority to US14/155,248 priority patent/US20140322217A1/en
Priority to US14/155,344 priority patent/US9701759B2/en
Priority to US201461938095P priority
Priority to US14/200,821 priority patent/US9605084B2/en
Priority to US14/200,652 priority patent/US20140302064A1/en
Priority to US14/205,248 priority patent/US9650446B2/en
Priority to US14/205,227 priority patent/US20140294835A1/en
Priority to US14/207,489 priority patent/US10131710B2/en
Application filed by Xencor Inc filed Critical Xencor Inc
Priority claimed from EP14733393.4A external-priority patent/EP2951203B1/en
Priority claimed from US14/216,705 external-priority patent/US20140363426A1/en
Publication of US20140377270A1 publication Critical patent/US20140377270A1/en
Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DESJARLAIS, JOHN, RASHID, Rumana, BERNETT, MATTHEW, MOORE, GREGORY
Priority claimed from US16/162,172 external-priority patent/US20190270810A1/en
Publication of US10131710B2 publication Critical patent/US10131710B2/en
Application granted granted Critical
Application status is Active legal-status Critical
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