AR127298A1 - Anticuerpos que se unen a cd30 y cd3 - Google Patents
Anticuerpos que se unen a cd30 y cd3Info
- Publication number
- AR127298A1 AR127298A1 ARP220102726A ARP220102726A AR127298A1 AR 127298 A1 AR127298 A1 AR 127298A1 AR P220102726 A ARP220102726 A AR P220102726A AR P220102726 A ARP220102726 A AR P220102726A AR 127298 A1 AR127298 A1 AR 127298A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- antibody
- multispecific antibody
- sequences
- nucleic acid
- Prior art date
Links
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 title abstract 4
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 6
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 150000001945 cysteines Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención se refiere a anticuerpos multiespecíficos que se unen a CD3 y CD30. La invención además proporciona composiciones farmacéuticas que comprenden anticuerpos de la invención, ácidos nucleicos que codifican los anticuerpos, células huésped que producen los anticuerpos, métodos para producir los anticuerpos y usos de los anticuerpos, en particular para la terapia del cáncer. Reivindicación 1: Un anticuerpo mutiespecífico que comprende: (i) una región de unión a CD30 que comprende una primera región variable de cadena pesada que comprende las secuencias de las CDR1, CDR2 y CDR3 de acuerdo con la SEQ ID Nº 1, 2 y 3, respectivamente, y una primera región variable de cadena ligera que comprende las secuencias de las CDR1, CDR2 y CDR3 de acuerdo con la SEQ ID Nº 4, 5 y 6, respectivamente, y (ii) una región de unión a CD3 que comprende una segunda región variable de cadena pesada que comprende las secuencias de las CDR1, CDR2 y CDR3 de acuerdo con la SEQ ID Nº 7, 8 y 9, respectivamente, y una segunda región variable de cadena ligera que comprende las secuencias de las CDR1, CDR2 y CDR3 de acuerdo con la SEQ ID Nº 10, 11 y 12, respectivamente. Reivindicación 28: Una construcción de ácido nucleico, o una combinación de construcciones de ácido nucleico, que codifica el anticuerpo multiespecífico de acuerdo con cualquiera de las reivindicaciones precedentes. Reivindicación 29: Un vector de expresión, o una combinación de vectores de expresión, que comprende la o las construcciones de ácido nucleico de acuerdo con la reivindicación 28. Reivindicación 30: Un vehículo de entrega que comprende la o las construcciones de ácido nucleico de acuerdo con la reivindicación 28. Reivindicación 34: Una célula huésped recombinante capaz de producir el anticuerpo multiespecífico de acuerdo con cualquiera de las reivindicaciones 1 a 27, en donde la célula huésped comprende una o más construcciones de ácido nucleico que codifican el anticuerpo multiespecífico de acuerdo con cualquiera de las reivindicaciones precedentes. Reivindicación 36: Una composición farmacéutica que comprende un anticuerpo multiespecífico de acuerdo con cualquiera de las reivindicaciones 1 a 27 y un portador farmacéuticamente aceptable. Reivindicación 45: Un método para producir un anticuerpo multiespecífico de acuerdo con cualquiera de las reivindicaciones 1 a 27, que comprende (i) cultivar la célula huésped recombinante de la reivindicación 34 o 35 bajo condiciones en las cuales el anticuerpo es producido, y (ii) aislar el anticuerpo multiespecífico producido del cultivo. Reivindicación 46: Un método para producir un anticuerpo multiespecífico de acuerdo con cualquiera de las reivindicaciones 9 a 26, que comprende a) proporcionar un primer anticuerpo que comprende la región de unión a CD30 conforme lo descripto en la reivindicación 1 (i), y un segundo anticuerpo que comprende la región de unión a CD3 conforme lo descripto en la reivindicación 1 (ii), en donde dichos anticuerpos opcionalmente contienen las características adicionales descriptas en las reivindicaciones 2 a 26, en donde los anticuerpos primero y segundo comprenden una región Fc, y en donde las secuencias de las regiones CH3 primera y segunda de los anticuerpos primero y segundo son diferentes y tales que la interacción heterodimérica entre las regiones CH3 primera y segunda es más fuerte que cada una de las interacciones homodiméricas de las regiones CH3 primera y segunda; b) incubar el primer anticuerpo junto con el segundo anticuerpo bajo condiciones de reducción suficientes para permitir que las cisteínas en las regiones bisagra sean sometidas a la isomerización de enlaces disulfuro; y c) obtener el anticuerpo multiespecífico que comprende la primera cadena pesada de inmunoglobulina y la primera cadena ligera de inmunoglobulina del primer anticuerpo y la segunda cadena pesada de inmunoglobulina y la segunda cadena ligera de inmunoglobulina del segundo anticuerpo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21201712 | 2021-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR127298A1 true AR127298A1 (es) | 2024-01-10 |
Family
ID=78087069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220102726A AR127298A1 (es) | 2021-10-08 | 2022-10-06 | Anticuerpos que se unen a cd30 y cd3 |
Country Status (10)
Country | Link |
---|---|
US (1) | US11814437B2 (es) |
JP (1) | JP7503215B2 (es) |
KR (1) | KR20240082397A (es) |
AR (1) | AR127298A1 (es) |
AU (1) | AU2022361691A1 (es) |
CA (1) | CA3234153A1 (es) |
CO (1) | CO2024005918A2 (es) |
IL (1) | IL311805A (es) |
TW (1) | TW202330610A (es) |
WO (1) | WO2023057571A1 (es) |
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KR20200064062A (ko) * | 2017-08-04 | 2020-06-05 | 젠맵 에이/에스 | Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도 |
US20210163594A1 (en) * | 2018-04-17 | 2021-06-03 | Invenra Inc. | Binding molecules |
CA3155293A1 (en) | 2018-09-24 | 2020-04-02 | The Medical College Of Wisconsin, Inc. | System and method for the development of cd30 bispecific antibodies for immunotherapy of cd30+ malignancies |
CR20210687A (es) * | 2019-06-25 | 2022-03-03 | Gilead Sciences Inc | PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO |
-
2022
- 2022-10-06 IL IL311805A patent/IL311805A/en unknown
- 2022-10-06 JP JP2023538860A patent/JP7503215B2/ja active Active
- 2022-10-06 CA CA3234153A patent/CA3234153A1/en active Pending
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- 2022-10-06 AR ARP220102726A patent/AR127298A1/es unknown
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- 2022-10-06 KR KR1020247014743A patent/KR20240082397A/ko unknown
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2024
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KR20240082397A (ko) | 2024-06-10 |
CA3234153A1 (en) | 2023-04-13 |
TW202330610A (zh) | 2023-08-01 |
AU2022361691A1 (en) | 2024-03-28 |
US20230132049A1 (en) | 2023-04-27 |
US11814437B2 (en) | 2023-11-14 |
US20240132607A1 (en) | 2024-04-25 |
JP7503215B2 (ja) | 2024-06-19 |
WO2023057571A1 (en) | 2023-04-13 |
JP2023551744A (ja) | 2023-12-12 |
IL311805A (en) | 2024-05-01 |
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