CY1124747T1 - Ανθρωπινα αντισωματα σε pd-1 - Google Patents

Ανθρωπινα αντισωματα σε pd-1

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Publication number
CY1124747T1
CY1124747T1 CY20211101017T CY211101017T CY1124747T1 CY 1124747 T1 CY1124747 T1 CY 1124747T1 CY 20211101017 T CY20211101017 T CY 20211101017T CY 211101017 T CY211101017 T CY 211101017T CY 1124747 T1 CY1124747 T1 CY 1124747T1
Authority
CY
Cyprus
Prior art keywords
antibodies
binds
disorder
bind
treating
Prior art date
Application number
CY20211101017T
Other languages
English (en)
Inventor
Nicholas J. Papadopoulos
Andrew J. Murphy
Gavin Thurston
Ella Ioffe
Elena BUROVA
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52462456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124747(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of CY1124747T1 publication Critical patent/CY1124747T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

Η παρούσα εφεύρεση παρέχει αντισώματα τα οποία συνδέονται με μια προγραμματισμένη πρωτεΐνη θανάτου-1 (PD-1) συν-αναστολέα Τ-κυττάρων. Σε διάφορες ενσωματώσεις της εφεύρεσης, τα αντισώματα είναι ανθρώπινα αντισώματα τα οποία συνδέονται στο PD-1. Σε ορισμένες ενσωματώσεις, η παρούσα εφεύρεση παρέχει πολυειδικά μόρια δέσμευσης αντιγόνου τα οποία περιλαμβάνουν μια πρώτη ειδικότητα δέσμευσης τα οποία συνδέονται στο PD-1 και μια δεύτερη ειδικότητα δέσμευσης τα οποία συνδέονται σε ένα αυτοάνοσο αντιγόνο ιστού, ένα άλλο υποδοχέα Τ-κυττάρων, έναν υποδοχέα Fc, ή έναν υποδοχέα Τ-κυττάρων. Σε μερικές ενσωματώσεις, τα αντισώματα της εφεύρεσης είναι χρήσιμα για την αναστολή ή την εξουδετέρωση της δραστηριότητας του PD-1. και επομένως παρέχοντας ένα μέσο για την θεραπεία μιας ασθένειας ή διαταραχής όπως ο καρκίνος, η χρόνια ιογενής λοίμωξη. Σε άλλες ενσωματώσεις, τα αντισώματα είναι χρήσιμα για την ενίσχυση ή διέγερση της δραστηριότητας του PD-1, και επομένως παρέχοντας ένα μέσο για τη θεραπεία, για παράδειγμα, μιας αυτοάνοσης ασθένειας ή διαταραχής.
CY20211101017T 2014-01-23 2021-11-24 Ανθρωπινα αντισωματα σε pd-1 CY1124747T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461930576P 2014-01-23 2014-01-23
US201462014181P 2014-06-19 2014-06-19
PCT/US2015/012589 WO2015112800A1 (en) 2014-01-23 2015-01-23 Human antibodies to pd-1

Publications (1)

Publication Number Publication Date
CY1124747T1 true CY1124747T1 (el) 2022-07-22

Family

ID=52462456

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211101017T CY1124747T1 (el) 2014-01-23 2021-11-24 Ανθρωπινα αντισωματα σε pd-1

Country Status (30)

Country Link
US (3) US9987500B2 (el)
EP (2) EP3967710A1 (el)
JP (4) JP6425730B2 (el)
KR (2) KR102337042B1 (el)
CN (2) CN106068275B (el)
AU (1) AU2015209233B2 (el)
BR (2) BR112016016699A2 (el)
CA (2) CA3207270A1 (el)
CL (1) CL2016001871A1 (el)
CY (1) CY1124747T1 (el)
DK (1) DK3097119T3 (el)
EA (1) EA034770B8 (el)
ES (1) ES2888224T3 (el)
HR (1) HRP20211794T1 (el)
HU (1) HUE056332T2 (el)
IL (2) IL246818B (el)
LT (1) LT3097119T (el)
MX (3) MX2016009554A (el)
MY (1) MY176475A (el)
NZ (1) NZ722342A (el)
PH (1) PH12016501330B1 (el)
PL (1) PL3097119T3 (el)
PT (1) PT3097119T (el)
RS (1) RS62507B1 (el)
SG (1) SG11201605482SA (el)
SI (1) SI3097119T1 (el)
TW (1) TWI681969B (el)
UA (1) UA122666C2 (el)
UY (1) UY35964A (el)
WO (1) WO2015112800A1 (el)

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