MX2018004177A - Terapia de combinacion para el tratamiento de cancer. - Google Patents

Terapia de combinacion para el tratamiento de cancer.

Info

Publication number
MX2018004177A
MX2018004177A MX2018004177A MX2018004177A MX2018004177A MX 2018004177 A MX2018004177 A MX 2018004177A MX 2018004177 A MX2018004177 A MX 2018004177A MX 2018004177 A MX2018004177 A MX 2018004177A MX 2018004177 A MX2018004177 A MX 2018004177A
Authority
MX
Mexico
Prior art keywords
human
molecule
specifically binds
cancer
treatment
Prior art date
Application number
MX2018004177A
Other languages
English (en)
Inventor
Koenig Scott
Bonvini Ezio
VASSELLI James
Marc Wigginton Jon
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX2018004177A publication Critical patent/MX2018004177A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

La presente invención está dirigida a una terapia de combinación que implica la administración de una primera molécula que se une específicamente a B7-H3 humana y una segunda molécula que se une específicamente a PD-1 humana, a un sujeto para el tratamiento de cáncer y/o inflamación. La invención también se refiere a composiciones farmacéuticas que comprenden una primera molécula que se une específicamente a B7-H3 humana y una segunda molécula que se une específicamente a PD-1 humana que son capaces de mediar, y muy preferiblemente potenciar, la activación del sistema inmunológico contra las células cancerosas que están asociadas con cualquiera de una variedad de cánceres humanos. La invención también se refiere al uso de dichas composiciones farmacéuticas para tratar cáncer y otras enfermedades en sujetos receptores.
MX2018004177A 2015-10-08 2016-10-06 Terapia de combinacion para el tratamiento de cancer. MX2018004177A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562239020P 2015-10-08 2015-10-08
PCT/US2016/055750 WO2017062619A2 (en) 2015-10-08 2016-10-06 Combination therapy for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2018004177A true MX2018004177A (es) 2018-09-11

Family

ID=58488465

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018004177A MX2018004177A (es) 2015-10-08 2016-10-06 Terapia de combinacion para el tratamiento de cancer.
MX2022015748A MX2022015748A (es) 2015-10-08 2018-04-05 Uso de una molecula anti-b7-h3 en combinacion con una molecula anti-pd-1 en la preparacion de formulaciones para el tratamiento de cancer.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022015748A MX2022015748A (es) 2015-10-08 2018-04-05 Uso de una molecula anti-b7-h3 en combinacion con una molecula anti-pd-1 en la preparacion de formulaciones para el tratamiento de cancer.

Country Status (17)

Country Link
US (2) US11174315B2 (es)
EP (1) EP3359192A4 (es)
JP (2) JP7320944B2 (es)
KR (1) KR20180084772A (es)
CN (1) CN108136010A (es)
AU (1) AU2016334041B2 (es)
BR (1) BR112018006817A2 (es)
GE (1) GEP20217317B (es)
HK (1) HK1251475A1 (es)
IL (1) IL258521B2 (es)
MA (1) MA45429A (es)
MX (2) MX2018004177A (es)
PH (1) PH12018500692A1 (es)
RU (1) RU2731202C2 (es)
TW (1) TW201718013A (es)
WO (1) WO2017062619A2 (es)
ZA (1) ZA201801797B (es)

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US11021537B2 (en) * 2017-05-01 2021-06-01 Agenus Inc. Anti-TIGIT antibodies and methods of use thereof
SG11202000115SA (en) * 2017-07-07 2020-02-27 Hanmi Pharmaceutical Co Ltd Novel therapeutic enzyme fusion protein and use thereof
NZ765453A (en) * 2017-12-22 2024-03-22 Hanmi Pharm Co Ltd Therapeutic enzyme fusion protein having novel structure and use thereof
US20220010018A1 (en) * 2018-11-16 2022-01-13 Albert Einstein College Of Medicine MONOCLONAL ANTIBODIES AGAINST IgV DOMAIN OF B7-H3 AND USES THEREOF
MX2022001111A (es) * 2019-08-02 2022-02-16 Cttq Akeso Shanghai Biomed Tech Co Ltd Anticuerpo anti-pd-1 y uso farmaceutico del mismo.
WO2021243028A1 (en) * 2020-05-27 2021-12-02 Dana-Farber Cancer Institute, Inc. Bispecific molecules for selectively modulating t cells
TW202304965A (zh) 2021-05-04 2023-02-01 美商艾吉納斯公司 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法
CN113999320B (zh) * 2021-11-02 2022-09-27 深圳先进技术研究院 以cd28和4-1bb为共刺激结构域的靶向cd276的嵌合抗原受体及其应用

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