MX2022001111A - Anticuerpo anti-pd-1 y uso farmaceutico del mismo. - Google Patents

Anticuerpo anti-pd-1 y uso farmaceutico del mismo.

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Publication number
MX2022001111A
MX2022001111A MX2022001111A MX2022001111A MX2022001111A MX 2022001111 A MX2022001111 A MX 2022001111A MX 2022001111 A MX2022001111 A MX 2022001111A MX 2022001111 A MX2022001111 A MX 2022001111A MX 2022001111 A MX2022001111 A MX 2022001111A
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MX
Mexico
Prior art keywords
antibody
cdr
seq
nos
amino acid
Prior art date
Application number
MX2022001111A
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English (en)
Inventor
Baiyong Li
Yu Xia
Zhongmin Wang
Peng Zhang
Original Assignee
Cttq Akeso Shanghai Biomed Tech Co Ltd
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Publication date
Application filed by Cttq Akeso Shanghai Biomed Tech Co Ltd filed Critical Cttq Akeso Shanghai Biomed Tech Co Ltd
Publication of MX2022001111A publication Critical patent/MX2022001111A/es

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Abstract

La presente invención se refiere al campo del tratamiento tumoral e inmunología molecular, y particularmente, a un anticuerpo anti-PD-1 y uso farmacéutico del mismo. Específicamente, la presente invención se refiere a un anticuerpo monoclonal, en donde una región variable de cadena pesada del anticuerpo monoclonal comprende CDRs con las secuencias de aminoácidos de SEQ ID NOs: 19-21, y/o una región variable de cadena ligera del anticuerpo monoclonal comprende CDRs con las secuencias de aminoácidos de SEQ ID NOs: 22-24; en donde de acuerdo con el sistema de numeración EU, una región constante de cadena pesada del anticuerpo comprende mutaciones en cualquiera de 2 o 3 de las posiciones 234, 235 y 237, y una constante de afinidad del anticuerpo a Fc?RIIIa y/o C1q se reduce después de la mutación comparado con aquel antes de la mutación. El anticuerpo monoclonal de la presente invención se pueden unir bien específicamente a PD-1, especialmente alivia la inmunosupresión de PD-1 en un organismo y activa los linfocitos T.
MX2022001111A 2019-08-02 2020-07-31 Anticuerpo anti-pd-1 y uso farmaceutico del mismo. MX2022001111A (es)

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CN201910711138 2019-08-02
CN201911105711 2019-11-13
CN201911105715 2019-11-13
CN201911133858 2019-11-19
PCT/CN2020/106219 WO2021023108A1 (zh) 2019-08-02 2020-07-31 一种抗pd-1抗体及其医药用途

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EP (1) EP4008351A4 (es)
JP (1) JP2022543114A (es)
KR (1) KR20220062503A (es)
CN (1) CN112300280B (es)
AU (1) AU2020324185A1 (es)
BR (1) BR112022002028A2 (es)
CA (1) CA3146777A1 (es)
IL (1) IL290256A (es)
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CN114191547A (zh) * 2021-12-23 2022-03-18 中山大学 仑伐替尼与pd-1单抗联用在制备抗肝癌药物中的应用
WO2024010861A2 (en) * 2022-07-06 2024-01-11 Santa Ana Bio, Inc. Methods and compositions for treating autoimmune, allergic and inflammatory diseases
CN117679505A (zh) * 2022-09-09 2024-03-12 中山康方生物医药有限公司 药物组合及用途
WO2024183643A1 (zh) * 2023-03-03 2024-09-12 正大天晴药业集团南京顺欣制药有限公司 含抗tim-3抗体的药物组合

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