SG11202000069XA - Novel anti-human ceacam5 antibody fab fragment - Google Patents
Novel anti-human ceacam5 antibody fab fragmentInfo
- Publication number
- SG11202000069XA SG11202000069XA SG11202000069XA SG11202000069XA SG11202000069XA SG 11202000069X A SG11202000069X A SG 11202000069XA SG 11202000069X A SG11202000069X A SG 11202000069XA SG 11202000069X A SG11202000069X A SG 11202000069XA SG 11202000069X A SG11202000069X A SG 11202000069XA
- Authority
- SG
- Singapore
- Prior art keywords
- fab fragment
- cancer
- human ceacam5
- antibody fab
- ceacam5 antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
NOVEL ANTI-HUMAN CEACAM5 ANTIBODY FAB FRAGMENT Provided are an anti-human CEACAM5 antibody Fab fragment expected to be useful in the diagnosis of a cancer, particularly, the diagnosis of colorectal cancer, breast cancer, lung cancer, thyroid gland cancer or a cancer resulting from the metastasis thereof, and a diagnosis approach using a conjugate comprising the Fab fragment. The present invention provides an anti-human CEACAM5 antibody Fab fragment comprising a heavy chain fragment comprising a heavy chain variable region consisting of the amino acid sequence represented by amino acid positions 1 to 121 of SEQ ID NO: 2, and a light chain comprising a light chain variable region consisting of the amino acid sequence represented by amino acid positions 1 to 112 of SEQ ID NO: 4, and a conjugate comprising the Fab fragment.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017133698 | 2017-07-07 | ||
PCT/JP2018/025618 WO2019009388A1 (en) | 2017-07-07 | 2018-07-06 | Novel anti-human ceacam5 antibody fab fragment |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000069XA true SG11202000069XA (en) | 2020-02-27 |
Family
ID=64950161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000069XA SG11202000069XA (en) | 2017-07-07 | 2018-07-06 | Novel anti-human ceacam5 antibody fab fragment |
Country Status (18)
Country | Link |
---|---|
US (1) | US11667724B2 (en) |
EP (1) | EP3650470A4 (en) |
JP (1) | JP7080002B2 (en) |
KR (1) | KR102665275B1 (en) |
CN (1) | CN110831977B (en) |
AU (1) | AU2018296644A1 (en) |
BR (1) | BR112020000274A2 (en) |
CA (1) | CA3068691A1 (en) |
CO (1) | CO2020000517A2 (en) |
IL (1) | IL271701A (en) |
JO (1) | JOP20200002A1 (en) |
MA (1) | MA51029A (en) |
PH (1) | PH12020500058A1 (en) |
SG (1) | SG11202000069XA (en) |
TW (1) | TWI795415B (en) |
UA (1) | UA126921C2 (en) |
WO (1) | WO2019009388A1 (en) |
ZA (1) | ZA202000219B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE058689T2 (en) | 2016-11-18 | 2022-09-28 | Astellas Pharma Inc | Novel anti-human muc1 antibody fab fragment |
TWI795415B (en) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | A novel anti-human CEACAM5 antibody Fab fragment |
MX2021004146A (en) * | 2018-10-10 | 2021-06-08 | Astellas Pharma Inc | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex. |
EP3981793A4 (en) * | 2019-06-04 | 2023-06-07 | Biotheus Inc. | Ceacam5-resistant monoclonal antibody and preparation method thereof and use thereof |
CA3188862A1 (en) | 2020-08-20 | 2022-02-24 | Carl Alexander Kamb | Compositions and methods for treating mesothelin positive cancers |
JP2023538115A (en) | 2020-08-20 | 2023-09-06 | エー2 バイオセラピューティクス, インコーポレイテッド | Compositions and methods for treating CEACAM-positive cancers |
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IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
WO2000066160A1 (en) | 1999-04-28 | 2000-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Parenteral medicinal composition containing humanized monoclonal antibody fragment and method for stabilizing the same |
US20020146750A1 (en) | 2000-03-30 | 2002-10-10 | Hoogenboom Hendricus R.J.M. | Mucin-1 specific binding members and methods of use thereof |
DE10303664A1 (en) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Detection molecules for the treatment and detection of tumors |
WO2005086875A2 (en) * | 2004-03-11 | 2005-09-22 | City Of Hope | A humanized anti-cea t84.66 antibody and uses thereof |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
BRPI0614100A2 (en) | 2005-08-03 | 2011-03-09 | Immunogen Inc | liquid immunoconjugate formulations |
EP3037544A1 (en) | 2005-10-13 | 2016-06-29 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of systemic lupus erythematosus (sle) patients with autoantibody positive diseases |
JP2010505775A (en) | 2006-10-04 | 2010-02-25 | クーベンハヴンス・ユニヴェルシテット | Production of cancer-specific immune response against MUC1 and cancer-specific MUC1 antibody |
EP2351777B1 (en) | 2008-10-28 | 2015-10-28 | Shionogi&Co., Ltd. | Anti-muc1 antibody |
EP2196476A1 (en) | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
CN101607985B (en) * | 2008-12-24 | 2013-03-27 | 中国科学院生物物理研究所 | Monoclonal antibody for anti-human CEA, a composition containing same and application thereof |
US8877157B2 (en) | 2009-07-08 | 2014-11-04 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
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CN102712921B (en) | 2009-09-24 | 2017-03-01 | 株式会社遗传科技 | Specifically it is used for humanized antibody of aminoacid sequence RGD of extracellular matrix protein and application thereof |
EP2347769A1 (en) | 2010-01-20 | 2011-07-27 | Glycotope GmbH | Cancer stem cell markers and uses thereof |
EP2565268A4 (en) | 2010-04-28 | 2013-10-09 | Shionogi & Co | Novel muc1 antibody |
CN101928347B (en) * | 2010-05-05 | 2013-03-27 | 上海海抗中医药科技发展有限公司 | Anti-carcinoembryonic-antigen (CEA) antibody and application thereof |
SG10201506030RA (en) | 2010-07-30 | 2015-09-29 | Medimmune Llc | Method for purifying active polypeptides or immunoconjugates |
CA2827722C (en) * | 2011-03-02 | 2020-05-12 | Roche Glycart Ag | Anti-cea antibodies |
JP6164556B2 (en) | 2011-12-01 | 2017-07-19 | 国立大学法人 千葉大学 | Drug for producing radiolabeled polypeptide with reduced nonspecific renal accumulation |
RS60043B1 (en) | 2012-11-20 | 2020-04-30 | Sanofi Sa | Anti-ceacam5 antibodies and uses thereof |
WO2014133093A1 (en) | 2013-02-28 | 2014-09-04 | 独立行政法人国立がん研究センター | Antibody against insoluble fibrin |
TWI679019B (en) | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | Anti-il-4/anti-il-13 bispecific antibody formulations |
HUE056325T2 (en) | 2013-08-26 | 2022-02-28 | Biontech Res And Development Inc | Nucleic acids encoding human antibodies to sialyl-lewis a |
TWI541022B (en) | 2013-12-18 | 2016-07-11 | 應克隆公司 | Compounds to fibroblast growth factor receptor-3 (fgfr3) and methods of treatment |
CA2942150A1 (en) | 2014-04-07 | 2015-10-15 | Seattle Genetics, Inc. | Stable formulations for anti-cd19 antibodies and antibody-drug conjugates |
RU2016144178A (en) | 2014-04-28 | 2018-05-10 | Медисинал Кемистри Фармасьютикалс, Ко., Лтд. | ANTI-BODY AGAINST MUC1 OR ITS ANTIGEN-BINDING Fragment AND ITS APPLICATION |
TWI705827B (en) | 2014-11-07 | 2020-10-01 | 瑞士商諾華公司 | Methods for treating ocular diseases |
EP3256494A4 (en) | 2015-02-10 | 2018-12-05 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies |
WO2017150549A1 (en) | 2016-03-01 | 2017-09-08 | 国立大学法人 千葉大学 | Radiolabeled drug |
HUE058689T2 (en) | 2016-11-18 | 2022-09-28 | Astellas Pharma Inc | Novel anti-human muc1 antibody fab fragment |
US10758632B2 (en) | 2017-02-06 | 2020-09-01 | City Of Hope | NIR-conjugated tumor-specific antibodies and uses thereof |
TWI795415B (en) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | A novel anti-human CEACAM5 antibody Fab fragment |
EP3689892A4 (en) | 2017-09-26 | 2021-05-12 | National University Corporation Chiba University | Radioactive drug |
KR20210011941A (en) | 2018-05-17 | 2021-02-02 | 아스텔라스세이야쿠 가부시키가이샤 | Complex comprising anti-human MUC1 antibody Fab fragment, peptide linker and/or ligand |
MX2021004146A (en) | 2018-10-10 | 2021-06-08 | Astellas Pharma Inc | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex. |
JOP20210183A1 (en) | 2019-01-07 | 2023-01-30 | Astellas Pharma Inc | Conjugate comprising ligand and ceacam5 antibody fab fragment |
-
2018
- 2018-07-05 TW TW107123231A patent/TWI795415B/en active
- 2018-07-06 UA UAA202000714A patent/UA126921C2/en unknown
- 2018-07-06 EP EP18827622.4A patent/EP3650470A4/en active Pending
- 2018-07-06 AU AU2018296644A patent/AU2018296644A1/en active Pending
- 2018-07-06 CN CN201880044520.9A patent/CN110831977B/en active Active
- 2018-07-06 JP JP2019527977A patent/JP7080002B2/en active Active
- 2018-07-06 KR KR1020197035209A patent/KR102665275B1/en active IP Right Grant
- 2018-07-06 MA MA051029A patent/MA51029A/en unknown
- 2018-07-06 SG SG11202000069XA patent/SG11202000069XA/en unknown
- 2018-07-06 CA CA3068691A patent/CA3068691A1/en active Pending
- 2018-07-06 WO PCT/JP2018/025618 patent/WO2019009388A1/en unknown
- 2018-07-06 US US16/628,975 patent/US11667724B2/en active Active
- 2018-07-06 JO JOP/2020/0002A patent/JOP20200002A1/en unknown
- 2018-07-06 BR BR112020000274-7A patent/BR112020000274A2/en unknown
-
2019
- 2019-12-25 IL IL271701A patent/IL271701A/en unknown
-
2020
- 2020-01-07 PH PH12020500058A patent/PH12020500058A1/en unknown
- 2020-01-13 ZA ZA2020/00219A patent/ZA202000219B/en unknown
- 2020-01-17 CO CONC2020/0000517A patent/CO2020000517A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2018296644A1 (en) | 2020-01-23 |
RU2020105654A (en) | 2021-08-09 |
JOP20200002A1 (en) | 2020-01-06 |
CO2020000517A2 (en) | 2020-01-31 |
US20200123270A1 (en) | 2020-04-23 |
CN110831977A (en) | 2020-02-21 |
JPWO2019009388A1 (en) | 2020-05-07 |
CN110831977B (en) | 2023-06-09 |
EP3650470A1 (en) | 2020-05-13 |
BR112020000274A2 (en) | 2020-07-14 |
KR20200026185A (en) | 2020-03-10 |
CA3068691A1 (en) | 2019-01-10 |
TW201920273A (en) | 2019-06-01 |
MA51029A (en) | 2021-03-24 |
US11667724B2 (en) | 2023-06-06 |
ZA202000219B (en) | 2021-08-25 |
KR102665275B1 (en) | 2024-05-13 |
RU2020105654A3 (en) | 2021-10-29 |
IL271701A (en) | 2020-02-27 |
EP3650470A4 (en) | 2021-03-24 |
TWI795415B (en) | 2023-03-11 |
UA126921C2 (en) | 2023-02-22 |
WO2019009388A1 (en) | 2019-01-10 |
PH12020500058A1 (en) | 2020-09-28 |
JP7080002B2 (en) | 2022-06-03 |
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