HRP20211794T1 - Humana antitijela za pd-1 - Google Patents
Humana antitijela za pd-1 Download PDFInfo
- Publication number
- HRP20211794T1 HRP20211794T1 HRP20211794TT HRP20211794T HRP20211794T1 HR P20211794 T1 HRP20211794 T1 HR P20211794T1 HR P20211794T T HRP20211794T T HR P20211794TT HR P20211794 T HRP20211794 T HR P20211794T HR P20211794 T1 HRP20211794 T1 HR P20211794T1
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- Prior art keywords
- antibody
- antigen
- binding fragment
- seq
- isolated
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- 239000012634 fragment Substances 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000013467 fragmentation Methods 0.000 claims 1
- 238000006062 fragmentation reaction Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Claims (12)
1. Izolirano antitijelo ili njegov fragment koji veže antigen koje se specifično veže za humani protein programirane smrti-1 (PD-1), pri čemu izolirano antitijelo ili njegov fragment koji veže antigen sadrži varijabilnu regiju teškog lanca (HCVR) koji ima SEQ ID NO: 162 i varijabilnu regiju lakog lanca (LCVR) koji ima SEQ ID NO: 170.
2. Izolirano antitijelo ili njegov fragment koji veže antigen prema patentnom zahtjevu 1, pri čemu antitijelo ili njegov fragment koji veže antigen je multi-specifična molekula koja veže antigen.
3. Izolirano antitijelo ili njegov fragment koji veže antigen prema patentnom zahtjevu 1 ili 2, pri čemu je antitijelo IgG1 ili IgG4 antitijelo.
4. Izolirano antitijelo ili njegov fragment koji veže antigen prema bilo kojem od patentnih zahtjeva 1-3, pri čemu antitijelo sadrži teški lanac i laki lanac, gdje teški lanac sadrži aminokiselinsku sekvencu koja je predstavljena u SEQ ID NO: 330 i/ili laki lanac sadrži aminokiselinsku sekvencu koja je predstavljena u SEQ ID NO: 331.
5. Izolirano antitijelo ili njegov fragment koji veže antigen prema bilo kojem od patentnih zahtjeva 1-4, pri čemu antitijelo sadrži aminokiselinski par sekvenci teškog/lakog lanca koji je predstavljen u SEQ ID NO: 330/331.
6. Farmaceutski sastav koji sadrži Izolirano antitijelo ili njegov fragment koji veže antigen koje se veže za PD-1 prema bilo kojem od patentnih zahtjeva 1- 5 i farmaceutski prihvatljivi nosač ili otapalo.
7. Izolirana polinukleotidna molekula koja sadrži polinukleotidnu sekvencu koja kodira za HCVR i polinukleotidnu sekvencu koja kodira za LCVR antitijela ili njegovog fragmenta koji veže antigen kao što je prikazano u bilo kojem od patentnih zahtjeva 1 - 5.
8. Vektor koji sadrži polinukleotidnu molekulu prema patentnom zahtjevu 7.
9. Stanica koja sadrži vektor prema patentnom zahtjevu 8.
10. Postupak za proizvodnju anti-PD-1 antitijela ili njegovog fragmenta koji veže antigen, koji obuhvaća kultiviranje stanice domaćina prema patentnom zahtjevu 9 pod uvjetima koji omogućavaju proizvodnju antitijela ili fragmenta, i regeneraciju tako proizvedenog antitijela ili fragmenta.
11. Postupak prema patentnom zahtjevu 10, koji dalje obuhvaća formuliranje antitijela ili njegovog fragmenta koji veže antigen kao farmaceutski sastav koji sadrži prihvatljivi nosač.
12. Postupak prema patentnom zahtjevu 10, pri čemu je stanica domaćina CHO stanica.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461930576P | 2014-01-23 | 2014-01-23 | |
US201462014181P | 2014-06-19 | 2014-06-19 | |
PCT/US2015/012589 WO2015112800A1 (en) | 2014-01-23 | 2015-01-23 | Human antibodies to pd-1 |
EP15703187.3A EP3097119B1 (en) | 2014-01-23 | 2015-01-23 | Human antibodies to pd-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20211794T1 true HRP20211794T1 (hr) | 2022-03-18 |
Family
ID=52462456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211794TT HRP20211794T1 (hr) | 2014-01-23 | 2015-01-23 | Humana antitijela za pd-1 |
Country Status (30)
Country | Link |
---|---|
US (3) | US9987500B2 (hr) |
EP (2) | EP3967710A1 (hr) |
JP (4) | JP6425730B2 (hr) |
KR (2) | KR20210152583A (hr) |
CN (2) | CN106068275B (hr) |
AU (1) | AU2015209233B2 (hr) |
BR (2) | BR112016016699A2 (hr) |
CA (2) | CA3207270A1 (hr) |
CL (1) | CL2016001871A1 (hr) |
CY (1) | CY1124747T1 (hr) |
DK (1) | DK3097119T3 (hr) |
EA (1) | EA034770B8 (hr) |
ES (1) | ES2888224T3 (hr) |
HR (1) | HRP20211794T1 (hr) |
HU (1) | HUE056332T2 (hr) |
IL (2) | IL246818B (hr) |
LT (1) | LT3097119T (hr) |
MX (3) | MX2016009554A (hr) |
MY (1) | MY176475A (hr) |
NZ (1) | NZ722342A (hr) |
PH (1) | PH12016501330A1 (hr) |
PL (1) | PL3097119T3 (hr) |
PT (1) | PT3097119T (hr) |
RS (1) | RS62507B1 (hr) |
SG (1) | SG11201605482SA (hr) |
SI (1) | SI3097119T1 (hr) |
TW (1) | TWI681969B (hr) |
UA (1) | UA122666C2 (hr) |
UY (1) | UY35964A (hr) |
WO (1) | WO2015112800A1 (hr) |
Families Citing this family (495)
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TWI686405B (zh) | 2008-12-09 | 2020-03-01 | 建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
PL3409278T3 (pl) | 2011-07-21 | 2021-02-22 | Sumitomo Pharma Oncology, Inc. | Heterocykliczne inhibitory kinazy białkowej |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
RS61400B1 (sr) | 2013-05-02 | 2021-02-26 | Anaptysbio Inc | Antitela usmerena protiv programirane smrti-1 (pd-1) |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
SG11201604738TA (en) | 2013-12-12 | 2016-07-28 | Shanghai Hengrui Pharm Co Ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
NZ725006A (en) | 2014-03-12 | 2019-11-29 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
WO2017042633A2 (en) * | 2015-09-10 | 2017-03-16 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
US9982053B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
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US11603407B2 (en) * | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
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