HRP20210372T1 - Anti-lag3 antitijela i antigen-vezujući fragmenti - Google Patents
Anti-lag3 antitijela i antigen-vezujući fragmenti Download PDFInfo
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- HRP20210372T1 HRP20210372T1 HRP20210372TT HRP20210372T HRP20210372T1 HR P20210372 T1 HRP20210372 T1 HR P20210372T1 HR P20210372T T HRP20210372T T HR P20210372TT HR P20210372 T HRP20210372 T HR P20210372T HR P20210372 T1 HRP20210372 T1 HR P20210372T1
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- Prior art keywords
- antibody
- antigen
- heavy chain
- binding fragment
- light chain
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- 239000000427 antigen Substances 0.000 title claims 15
- 102000036639 antigens Human genes 0.000 title claims 15
- 108091007433 antigens Proteins 0.000 title claims 15
- 239000012634 fragment Substances 0.000 title claims 15
- 108060003951 Immunoglobulin Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102000018358 immunoglobulin Human genes 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 6
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 5
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 5
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 5
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 101100510618 Homo sapiens LAG3 gene Proteins 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
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- Oncology (AREA)
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- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (21)
1. Antitijelo ili njegov antigen-vezujući fragment koje se specifično veže za ljudski LAG3 i sadrži varijabilnu domenu lakog lanca koji sadrži aminokiselinsku sekvencu prikazanu u aminokiselinama 21-131 prema SEQ ID NO: 126 i varijabilnu domenu teškog lanca koji sadrži aminokiselinsku sekvencu prikazanu u aminokiselinama 1-119 prema SEQ ID NO: 116.
2. Antitijelo ili njegov antigen-vezujući fragment prema patentnom zahtjevu 1 koje sadrži imunoglobulin lakog lanca koji sadrži aminokiselinsku sekvencu prikazanu u aminokiselinama 21-238 prema SEQ ID NO: 126 i imunoglobulin teškog lanca koji sadrži aminokiselinsku sekvencu prikazanu u SEQ ID NO: 116.
3. Antitijelo prema patentnom zahtjevu 1 koje se sastoji od dva imunoglobulina lakog lanca i dva imunoglobulina teškog lanca, pri čemu se svaki imunoglobulin lakog lanca sastoji od aminokiselinske sekvence prikazane u aminokiselinama 21-238 prema SEQ ID NO: 126 i svaki imunoglobulin teškog lanca se sastoji od aminokiselinske sekvence varijabilne domene teškog lanca prikazane u aminokiselinama 1-119 prema SEQ ID NO: 116 i konstantne regije ljudskog IgG4.
4. Antitijelo prema patentnom zahtjevu 3, naznačeno time što konstantna regija ljudskog IgG4 sadrži S228P mutaciju prema EU sistemu.
5. Antitijelo prema patentnom zahtjevu 1 koje se sastoji od dva imunoglobulina lakog lanca i dva imunoglobulina teškog lanca, pri čemu svaki imunoglobulin lakog lanca sadrži aminokiselinsku sekvencu prikazanu u aminokiselinama 21-238 prema SEQ ID NO: 126 i svaki imunoglobulin teškog lanca sadrži aminokiselinsku sekvencu prikazanu u SEQ ID NO: 116.
6. Antitijelo prema patentnom zahtjevu 1 koje se sastoji od dva imunoglobulina lakog lanca i dva imunoglobulina teškog lanca, pri čemu se svaki imunoglobulin lakog lanca sastoji od aminokiselinske sekvence prikazane u aminokiselinama 21-238 prema SEQ ID NO: 126 i svaki imunoglobulin teškog lanca se sastoji od aminokiselinske sekvence prikazane u SEQ ID NO: 116.
7. Antitijelo prema patentnom zahtjevu 1, koje se sastoji od dva imunoglobulina lakog lanca i dva imunoglobulina teškog lanca, pri čemu se svaki imunoglobulin lakog lanca sastoji od aminokiselinske sekvence prikazane u aminokiselinama 21-238 prema SEQ ID NO: 126 i svaki imunoglobulin teškog lanca sadrži aminokiselinsku sekvencu prikazanu aminokiselinama 1-119 prema SEQ ID NO: 116.
8. Antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1-7 koje je eksprimirano iz stanice jajnika kineskog hrčka.
9. Antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1-7 koje je glikozilirano sa jednim ili više CHO N-vezanih glikana koji su G0-F, G1 -F, G2-F, G0, G1, G2 ili Man5.
10. Pripravak koji sadrži antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1 do 9 i farmaceutski prihvatljiv nosač ili razblaživač.
11. Pripravak prema patentnom zahtjevu 10 koji dodatno sadrži anti-PD-1 antitijelo.
12. Pripravak prema patentnom zahtjevu 11, naznačen time što, anti-PD-1 antitijelo je pembrolizumab.
13. Uređaj za ubrizgavanje koji sadrži antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1-9 ili pripravak prema bilo kojem od patentnih zahtjeva 10-12.
14. Polinukleotid koji kodira: varijabilnu domenu lakog lanca i varijabilnu domenu teškog lanca ili imunoglobulin lakog lanca i imunoglobulin teškog lanca antitijela ili antigen-vezujućih fragmenata prema bilo kojem od patentnih zahtjeva 1-9.
15. Vektor koji sadrži polinukleotid prema patentnom zahtjevu 14.
16. Stanica domaćina koja sadrži antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1-9, polinukleotid prema patentnom zahtjevu 14 ili vektor prema patentnom zahtjevu 15.
17. Postupak za proizvodnju antitijela ili njegovog antigen-vezujućeg fragmenta prema bilo kojem od patentnih zahtjeva 1-9 koji sadrži:
a. kultiviranje stanice domaćina koja sadrži polinukleotid koji kodira imunoglobulin lakog lanca i imunoglobulin teškog lanca antitijela, ili varijabilnu domenu lakog lanca i varijabilnu domenu teškog lanca antigen-vezujućeg fragmenta u mediju kulture pod uvjetima povoljnim za ekspresiju polinukleotida; i
b. izborno, izoliranje antitijela ili antigen-vezujućeg fragmenta iz stanice domaćina i/ili mediju kulture.
18. Postupak prema patentnom zahtjevu 17 naznačen time što stanica domaćina je stanica jajnika kineskog hrčka.
19. Antitijelo ili njegov antigen-vezujući fragment koje se specifično veže za ljudski LAG3 koje je proizvod postupka prema patentnom zahtjevu 17 ili 18.
20. Antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1-9 ili pripravak prema bilo kojem od patentnih zahtjeva 10-12, za uporabu u liječenju ljudskog tijela terapijom.
21. Antitijelo ili antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1-9 ili pripravak prema bilo kojem od patentnih zahtjeva 10-12, za uporabu u liječenju raka.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462039081P | 2014-08-19 | 2014-08-19 | |
US201562171319P | 2015-06-05 | 2015-06-05 | |
PCT/US2015/045481 WO2016028672A1 (en) | 2014-08-19 | 2015-08-17 | Anti-lag3 antibodies and antigen-binding fragments |
EP15753877.8A EP3182999B1 (en) | 2014-08-19 | 2015-08-17 | Anti-lag3 antibodies and antigen-binding fragments |
Publications (1)
Publication Number | Publication Date |
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HRP20210372T1 true HRP20210372T1 (hr) | 2021-07-09 |
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ID=53938468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210372TT HRP20210372T1 (hr) | 2014-08-19 | 2021-03-03 | Anti-lag3 antitijela i antigen-vezujući fragmenti |
Country Status (40)
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2616355T3 (es) | 2007-06-18 | 2017-06-12 | Merck Sharp & Dohme B.V. | Anticuerpos para el receptor humano de muerte programada PD-1 |
EP2734205B1 (en) | 2011-07-21 | 2018-03-21 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
WO2014110601A1 (en) | 2013-01-14 | 2014-07-17 | Xencor, Inc. | Novel heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
SI3081576T1 (sl) | 2013-12-12 | 2019-12-31 | Shanghai Hengrui Pharmaceutical Co., Ltd., | Protitelo PD-1, njegov antigen-vezavni fragment in njegova medicinska uporaba |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
HUE048531T2 (hu) | 2014-03-14 | 2020-07-28 | Novartis Ag | Antitest molekulák a LAG-3-hoz és ezek felhasználása |
PL3122781T3 (pl) | 2014-03-28 | 2020-06-15 | Xencor, Inc. | Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3 |
EA201692458A1 (ru) | 2014-05-28 | 2017-06-30 | Агенус Инк. | Анти-gitr антитела и способы их применения |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
JO3663B1 (ar) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
US9993551B2 (en) | 2014-09-13 | 2018-06-12 | Novartis Ag | Combination therapies of EGFR inhibitors |
ES2774448T3 (es) * | 2014-10-03 | 2020-07-21 | Novartis Ag | Terapias de combinación |
TN2017000129A1 (en) | 2014-10-14 | 2018-10-19 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-l1 and uses thereof |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
EA037065B1 (ru) | 2014-11-26 | 2021-02-01 | Ксенкор, Инк. | Гетеродимерные антитела, связывающие cd3 и cd38 |
BR112017011092A2 (pt) | 2014-11-26 | 2017-12-26 | Xencor Inc | anticorpos heterodiméricos que ligam cd3 e antígenos de tumor |
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