MX2019005426A - Anticuerpos anti-lag3 y fragmentos de union a antigeno. - Google Patents

Anticuerpos anti-lag3 y fragmentos de union a antigeno.

Info

Publication number
MX2019005426A
MX2019005426A MX2019005426A MX2019005426A MX2019005426A MX 2019005426 A MX2019005426 A MX 2019005426A MX 2019005426 A MX2019005426 A MX 2019005426A MX 2019005426 A MX2019005426 A MX 2019005426A MX 2019005426 A MX2019005426 A MX 2019005426A
Authority
MX
Mexico
Prior art keywords
antibodies
fragments
antigen
binding fragments
lag3 antibodies
Prior art date
Application number
MX2019005426A
Other languages
English (en)
Inventor
Laurence Fayadat-Dilman
Rene De Waal Malefyt
Linda Liang
Gopalan Raghunathan
Original Assignee
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53938468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019005426(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Llc filed Critical Merck Sharp & Dohme Llc
Publication of MX2019005426A publication Critical patent/MX2019005426A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención incluye anticuerpos y fragmentos de unión a antígeno de los mismos que se unen específicamente a LAG3 de ser humano o de mono cinomolgo así como cadenas de inmunoglobulina de los mismos y poli nucleótidos que codifican los 5 mismos junto con dispositivos de inyección que comprenden dichos anticuerpos o fragmentos; las vacunas que incluyen dichos anticuerpos y fragmentos, así como las composiciones que comprenden los anticuerpos y fragmentos (por ejemplo, incluyendo anticuerpos anti-PD1) se incluyen en la invención; también se proporcionan métodos para el tratamiento o la prevención de cáncer o 10 infección usando dichas composiciones; además, los métodos de expresión recombinante de los anticuerpos y fragmentos son parte de la presente invención.
MX2019005426A 2014-08-19 2017-02-17 Anticuerpos anti-lag3 y fragmentos de union a antigeno. MX2019005426A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462039081P 2014-08-19 2014-08-19
US201562171319P 2015-06-05 2015-06-05

Publications (1)

Publication Number Publication Date
MX2019005426A true MX2019005426A (es) 2023-04-27

Family

ID=53938468

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017002230A MX2017002230A (es) 2014-08-19 2015-08-17 Anticuerpos anti-lag3 y fragmentos de union a antigeno.
MX2019005426A MX2019005426A (es) 2014-08-19 2017-02-17 Anticuerpos anti-lag3 y fragmentos de union a antigeno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017002230A MX2017002230A (es) 2014-08-19 2015-08-17 Anticuerpos anti-lag3 y fragmentos de union a antigeno.

Country Status (40)

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US (6) US20170290914A1 (es)
EP (2) EP3182999B1 (es)
JP (3) JP2017532059A (es)
KR (2) KR102321166B1 (es)
CN (1) CN107001470B (es)
AP (1) AP2017009763A0 (es)
AU (2) AU2018278910A1 (es)
BR (1) BR112017003194B8 (es)
CA (2) CA3082655A1 (es)
CL (1) CL2017000311A1 (es)
CO (1) CO2017001558A2 (es)
CR (1) CR20170059A (es)
CY (1) CY1124252T1 (es)
DK (1) DK3182999T3 (es)
DO (1) DOP2017000047A (es)
ES (1) ES2857505T3 (es)
GE (1) GEP20227343B (es)
GT (1) GT201700034A (es)
HR (1) HRP20210372T1 (es)
HU (1) HUE053641T2 (es)
IL (2) IL297053A (es)
JO (1) JO3663B1 (es)
LT (1) LT3182999T (es)
MA (2) MA55347A (es)
MD (1) MD4716C1 (es)
MX (2) MX2017002230A (es)
MY (1) MY187262A (es)
NI (1) NI201700018A (es)
PE (1) PE20170288A1 (es)
PH (1) PH12017500297A1 (es)
PL (1) PL3182999T3 (es)
PT (1) PT3182999T (es)
RS (1) RS61559B1 (es)
SG (1) SG11201701090VA (es)
SI (1) SI3182999T1 (es)
TN (1) TN2017000025A1 (es)
TW (3) TWI698448B (es)
UA (2) UA119571C2 (es)
WO (1) WO2016028672A1 (es)
ZA (2) ZA201700956B (es)

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KR102037197B1 (ko) 2019-10-28
US20170290914A1 (en) 2017-10-12
CA3082655A1 (en) 2016-02-25
CL2017000311A1 (es) 2017-08-18
AU2020230256A1 (en) 2020-10-01
AU2018278910A1 (en) 2019-01-03
SI3182999T1 (sl) 2021-04-30
PH12017500297A1 (en) 2017-07-17
EP3834842A1 (en) 2021-06-16
EP3182999B1 (en) 2021-01-06
CN107001470B (zh) 2021-06-22
KR102321166B1 (ko) 2021-11-02
US20190083615A1 (en) 2019-03-21
CY1124252T1 (el) 2022-07-22
PL3182999T3 (pl) 2021-05-31
LT3182999T (lt) 2021-03-25
BR112017003194B8 (pt) 2023-04-18
US11278620B2 (en) 2022-03-22
WO2016028672A1 (en) 2016-02-25
BR112017003194B1 (pt) 2020-06-09
CA2957275C (en) 2020-08-25
JP6538247B2 (ja) 2019-07-03
ZA201700956B (en) 2022-05-25
CA2957275A1 (en) 2016-02-25
AU2015305770B2 (en) 2018-09-13
TW201920284A (zh) 2019-06-01
JP6843174B2 (ja) 2021-03-17
PE20170288A1 (es) 2017-04-05
MA55347A (fr) 2022-01-26
AP2017009763A0 (en) 2016-02-28
SG11201701090VA (en) 2017-03-30
US20190091332A1 (en) 2019-03-28
IL250566B2 (en) 2023-03-01
AU2015305770A1 (en) 2017-03-09
BR112017003194A2 (pt) 2017-11-28
KR20190122881A (ko) 2019-10-30
CR20170059A (es) 2017-04-28
DK3182999T3 (da) 2021-03-15
JP2018183173A (ja) 2018-11-22
US11207406B2 (en) 2021-12-28
HRP20210372T1 (hr) 2021-07-09
HUE053641T2 (hu) 2021-07-28
JO3663B1 (ar) 2020-08-27
TW201613979A (en) 2016-04-16
CN107001470A (zh) 2017-08-01
US10188730B2 (en) 2019-01-29
MD4716C1 (ro) 2021-05-31
US10898571B2 (en) 2021-01-26
ES2857505T3 (es) 2021-09-29
US20220257762A1 (en) 2022-08-18
TWI742395B (zh) 2021-10-11
PT3182999T (pt) 2021-03-01

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