MA40536A - Anticorps anti-alpha v bêta 5 humanisés et leurs utilisations - Google Patents
Anticorps anti-alpha v bêta 5 humanisés et leurs utilisationsInfo
- Publication number
- MA40536A MA40536A MA040536A MA40536A MA40536A MA 40536 A MA40536 A MA 40536A MA 040536 A MA040536 A MA 040536A MA 40536 A MA40536 A MA 40536A MA 40536 A MA40536 A MA 40536A
- Authority
- MA
- Morocco
- Prior art keywords
- antibodies
- beta
- alpha
- humanized anti
- disclosed
- Prior art date
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La présente invention concerne des anticorps et des fragments d'anticorps humanisés qui se lient au αvβ5. L'invention concerne également des méthodes d'utilisation de ces anticorps et de ces fragments d'anticorps pour traiter ou prévenir des maladies à médiation par l'αvβ5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462049987P | 2014-09-12 | 2014-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA40536A true MA40536A (fr) | 2016-03-17 |
Family
ID=54150752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA040536A MA40536A (fr) | 2014-09-12 | 2015-09-11 | Anticorps anti-alpha v bêta 5 humanisés et leurs utilisations |
Country Status (9)
Country | Link |
---|---|
US (1) | US20170362324A1 (fr) |
EP (1) | EP3191519A1 (fr) |
JP (1) | JP2017534252A (fr) |
CN (1) | CN107001469A (fr) |
AU (1) | AU2015314809A1 (fr) |
CA (1) | CA2959772A1 (fr) |
MA (1) | MA40536A (fr) |
MX (1) | MX2017003014A (fr) |
WO (1) | WO2016040839A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102481347A (zh) * | 2009-07-24 | 2012-05-30 | 加州大学董事会 | 治疗和预防整合素αvβ5相关疾病的方法及组合物 |
CA3223687A1 (fr) * | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Anticorps neutralisants diriges contre le complexe d'integrine .alpha.v.beta.8 pour l'immunotherapie |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053041B1 (en) * | 1996-05-31 | 2006-05-30 | The Scripps Research Institute | Methods and compositions useful for inhibition of αvβ5mediated angiogenesis |
KR20000016301A (ko) * | 1996-05-31 | 2000-03-25 | 빙검 더글라스 에이. | 혈관 형성 억제에 유용한 방법 및 조성물 |
US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
US7288390B2 (en) * | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
PT1734996E (pt) * | 2004-04-02 | 2013-07-18 | Univ California | Métodos e composição para tratamento e prevenção de doenças associadas a integrina αvβ5 |
CN101001872A (zh) * | 2004-04-16 | 2007-07-18 | 宏观基因有限公司 | FcγRIIB-特异性抗体及其使用方法 |
CN102481347A (zh) * | 2009-07-24 | 2012-05-30 | 加州大学董事会 | 治疗和预防整合素αvβ5相关疾病的方法及组合物 |
WO2012027745A1 (fr) * | 2010-08-27 | 2012-03-01 | University Of Miami | Traitement de maladies rénales |
CN105121472A (zh) * | 2012-10-30 | 2015-12-02 | 埃斯佩兰斯医药公司 | 抗体/药物缀合物及其使用方法 |
-
2015
- 2015-09-11 MA MA040536A patent/MA40536A/fr unknown
- 2015-09-11 EP EP15767053.0A patent/EP3191519A1/fr not_active Withdrawn
- 2015-09-11 CN CN201580055534.7A patent/CN107001469A/zh active Pending
- 2015-09-11 AU AU2015314809A patent/AU2015314809A1/en not_active Abandoned
- 2015-09-11 CA CA2959772A patent/CA2959772A1/fr not_active Abandoned
- 2015-09-11 MX MX2017003014A patent/MX2017003014A/es unknown
- 2015-09-11 US US15/510,422 patent/US20170362324A1/en not_active Abandoned
- 2015-09-11 JP JP2017513632A patent/JP2017534252A/ja active Pending
- 2015-09-11 WO PCT/US2015/049746 patent/WO2016040839A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP3191519A1 (fr) | 2017-07-19 |
AU2015314809A1 (en) | 2017-03-16 |
JP2017534252A (ja) | 2017-11-24 |
US20170362324A1 (en) | 2017-12-21 |
WO2016040839A1 (fr) | 2016-03-17 |
CN107001469A (zh) | 2017-08-01 |
CA2959772A1 (fr) | 2016-03-17 |
MX2017003014A (es) | 2017-05-30 |
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