SI3456346T1 - Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh - Google Patents

Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh

Info

Publication number
SI3456346T1
SI3456346T1 SI201631326T SI201631326T SI3456346T1 SI 3456346 T1 SI3456346 T1 SI 3456346T1 SI 201631326 T SI201631326 T SI 201631326T SI 201631326 T SI201631326 T SI 201631326T SI 3456346 T1 SI3456346 T1 SI 3456346T1
Authority
SI
Slovenia
Prior art keywords
lag
methods
binding molecules
molecules
binding
Prior art date
Application number
SI201631326T
Other languages
English (en)
Inventor
Kalpana Shah
Douglas H. Smith
Motte-Mohs Ross La
Leslie S. Johnson
Paul A. Moore
Ezio Bonvini
Scott Koenig
Original Assignee
Macrogenics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of SI3456346T1 publication Critical patent/SI3456346T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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    • G—PHYSICS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K—PEPTIDES
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    • C07K—PEPTIDES
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    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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SI201631326T 2015-07-30 2016-07-28 Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh SI3456346T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562198867P 2015-07-30 2015-07-30
US201562239559P 2015-10-09 2015-10-09
US201562255140P 2015-11-13 2015-11-13
US201662322974P 2016-04-15 2016-04-15
EP18199685.1A EP3456346B1 (en) 2015-07-30 2016-07-28 Pd-1 and lag-3 binding molecules and methods of use thereof

Publications (1)

Publication Number Publication Date
SI3456346T1 true SI3456346T1 (sl) 2021-11-30

Family

ID=57884977

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201631326T SI3456346T1 (sl) 2015-07-30 2016-07-28 Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh
SI201631367T SI3328419T1 (sl) 2015-07-30 2016-07-28 PD-1-vezavne molekule in postopki uporabe le-teh

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201631367T SI3328419T1 (sl) 2015-07-30 2016-07-28 PD-1-vezavne molekule in postopki uporabe le-teh

Country Status (36)

Country Link
US (3) US10577422B2 (sl)
EP (3) EP3328419B1 (sl)
JP (4) JP6959907B2 (sl)
KR (2) KR20180034588A (sl)
CN (4) CN108976300B (sl)
AU (4) AU2016298227B9 (sl)
CA (1) CA2993948A1 (sl)
CL (1) CL2018000254A1 (sl)
CO (1) CO2018000867A2 (sl)
CR (3) CR20180062A (sl)
CY (2) CY1124634T1 (sl)
DK (2) DK3456346T3 (sl)
EA (1) EA201890296A1 (sl)
EC (1) ECSP18006831A (sl)
ES (2) ES2898958T3 (sl)
GE (3) GEP20227419B (sl)
HK (1) HK1248106A1 (sl)
HR (2) HRP20211645T1 (sl)
HU (2) HUE056201T2 (sl)
IL (4) IL287916B2 (sl)
JO (2) JO3736B1 (sl)
LT (2) LT3456346T (sl)
MA (1) MA42542B1 (sl)
MD (2) MD3328419T2 (sl)
MX (3) MX2018001227A (sl)
PE (3) PE20240111A1 (sl)
PH (1) PH12018500232A1 (sl)
PL (2) PL3456346T3 (sl)
PT (2) PT3328419T (sl)
RS (2) RS62568B1 (sl)
SG (2) SG10201906059VA (sl)
SI (2) SI3456346T1 (sl)
TW (3) TWI691509B (sl)
UA (1) UA127372C2 (sl)
WO (1) WO2017019846A1 (sl)
ZA (2) ZA201800500B (sl)

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US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
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ME03666B (me) 2014-03-28 2020-10-20 Xencor Inc Bispecifična antitela koja se vezuju za cd38 i cd3
RU2718692C2 (ru) * 2014-05-29 2020-04-13 Мэкроудженикс, Инк. Триспецифичные связывающие молекулы, которые специфически связывают антигены множества злокачественных опухолей, и способы их применения
TWI693232B (zh) * 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
EP3223907A2 (en) 2014-11-26 2017-10-04 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cd38
KR20170084326A (ko) 2014-11-26 2017-07-19 젠코어 인코포레이티드 Ｃｄ3 및 종양 항원과 결합하는 이종이량체 항체
US10428155B2 (en) 2014-12-22 2019-10-01 Xencor, Inc. Trispecific antibodies
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
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