SI3456346T1 - Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh - Google Patents

Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh

Info

Publication number
SI3456346T1
SI3456346T1 SI201631326T SI201631326T SI3456346T1 SI 3456346 T1 SI3456346 T1 SI 3456346T1 SI 201631326 T SI201631326 T SI 201631326T SI 201631326 T SI201631326 T SI 201631326T SI 3456346 T1 SI3456346 T1 SI 3456346T1
Authority
SI
Slovenia
Prior art keywords
lag
methods
binding molecules
molecules
binding
Prior art date
Application number
SI201631326T
Other languages
English (en)
Inventor
Kalpana Shah
Douglas H. Smith
Motte-Mohs Ross La
Leslie S. Johnson
Paul A. Moore
Ezio Bonvini
Scott Koenig
Original Assignee
Macrogenics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of SI3456346T1 publication Critical patent/SI3456346T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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    • G—PHYSICS
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
SI201631326T 2015-07-30 2016-07-28 Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh SI3456346T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562198867P 2015-07-30 2015-07-30
US201562239559P 2015-10-09 2015-10-09
US201562255140P 2015-11-13 2015-11-13
US201662322974P 2016-04-15 2016-04-15
EP18199685.1A EP3456346B1 (en) 2015-07-30 2016-07-28 Pd-1 and lag-3 binding molecules and methods of use thereof

Publications (1)

Publication Number Publication Date
SI3456346T1 true SI3456346T1 (sl) 2021-11-30

Family

ID=57884977

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201631326T SI3456346T1 (sl) 2015-07-30 2016-07-28 Molekule za vezavo PD-1 in LAG-3 in postopki za uporabo le-teh
SI201631367T SI3328419T1 (sl) 2015-07-30 2016-07-28 PD-1-vezavne molekule in postopki uporabe le-teh

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201631367T SI3328419T1 (sl) 2015-07-30 2016-07-28 PD-1-vezavne molekule in postopki uporabe le-teh

Country Status (36)

Country Link
US (3) US10577422B2 (sl)
EP (3) EP3456346B1 (sl)
JP (4) JP6959907B2 (sl)
KR (2) KR20180034588A (sl)
CN (4) CN114773475B (sl)
AU (4) AU2016298227B9 (sl)
CA (1) CA2993948A1 (sl)
CL (1) CL2018000254A1 (sl)
CO (1) CO2018000867A2 (sl)
CR (3) CR20220194A (sl)
CY (2) CY1124634T1 (sl)
DK (2) DK3456346T3 (sl)
EA (1) EA201890296A1 (sl)
EC (1) ECSP18006831A (sl)
ES (2) ES2898511T3 (sl)
GE (3) GEP20237538B (sl)
HK (1) HK1248106A1 (sl)
HR (2) HRP20211645T1 (sl)
HU (2) HUE056201T2 (sl)
IL (4) IL297090A (sl)
JO (2) JO3736B1 (sl)
LT (2) LT3328419T (sl)
MA (1) MA42542B1 (sl)
MD (2) MD3456346T2 (sl)
MX (3) MX2018001227A (sl)
PE (3) PE20240111A1 (sl)
PH (1) PH12018500232A1 (sl)
PL (2) PL3456346T3 (sl)
PT (2) PT3328419T (sl)
RS (2) RS62568B1 (sl)
SG (2) SG10202010506TA (sl)
SI (2) SI3456346T1 (sl)
TW (3) TWI833183B (sl)
UA (1) UA127372C2 (sl)
WO (1) WO2017019846A1 (sl)
ZA (2) ZA201800500B (sl)

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BRPI0915692B8 (pt) 2008-07-08 2021-05-25 Incyte Corp compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos
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US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
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US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
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US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
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SG10202008629XA (en) 2014-03-28 2020-10-29 Xencor Inc Bispecific antibodies that bind to cd38 and cd3
TWI707872B (zh) * 2014-05-29 2020-10-21 美商宏觀基因股份有限公司 特異性結合多種癌症抗原的三特異性結合分子和其使用方法
TWI693232B (zh) * 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
IL252480B2 (en) 2014-11-26 2023-12-01 Xencor Inc Heterodimeric antibodies that bind CD3 and tumor antigens
JP2017536830A (ja) 2014-11-26 2017-12-14 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． Ｃｄ３及びｃｄ３８に結合するヘテロ二量体抗体
EP3237449A2 (en) 2014-12-22 2017-11-01 Xencor, Inc. Trispecific antibodies
CN113004278B (zh) 2015-02-20 2023-07-21 因赛特控股公司 作为fgfr抑制剂的双环杂环
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
TW201709929A (zh) 2015-06-12 2017-03-16 宏觀基因股份有限公司 治療癌症的聯合療法
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